Adjuvant Chemoradiation for Adenocarcinoma of the Pancreas: The Johns Hopkins Experience

Carolyn Vachani RN, MSN, AOCN
OncoLink
Last Modified: November 18, 2006

Share article


Adjuvant Chemoradiation for Adenocarcinoma of the Pancreas: The Johns Hopkins Experience

At the time of diagnosis, 15% to 20% of patients will have resectable pancreatic cancers. The 5-year survival for patients after surgical resection is between 20% and 25%. The use of chemotherapy and radiation therapy following surgery is controversial, with 3 clinical trials showing conflicting results regarding the benefits of chemoradiotherapy after surgery. American physicians tend to give chemo-radiotherapy in this disease, while their European counterparts often omit such therapy. This study was done to examine the effect of chemoradiation therapy after Whipple resection at a single, high-volume medical center.

The 155 patients included in the analysis received 5-FU and radiation therapy after surgical resection. There is a median follow up of 5.8 years. Patients who did not receive adjuvant therapy had worse median survival than the patients who received adjuvant therapy (16 months vs. 21 months with adjuvant therapy), worse 2-year overall survival (36% vs. 45% with adjuvant therapy), and worse 5-year overall survival (16% vs. 25% with adjuvant therapy).

These results compare favorably with results seen in previous randomized trials, despite the fact that the patients treated at Johns Hopkins had more advanced disease and higher positive margin rates. 5-FU-based chemoradiation after surgery is associated with improved survival compared to observation alone. Survival data from this series are consistent with previously reported studies of patients treated with adjuvant chemoradiation, and lend support to its continued use after definitive surgery.


News
FDA Clears Test to Help Detect Ovarian Cancer

Sep 2, 2014 - On Sept. 11, the U.S. Food and Drug Administration cleared OVA1, a test that helps detect ovarian cancer in women with pelvic masses requiring surgery. OVA1 was developed by Vermillion Inc., headquartered in Fremont, Calif., in conjunction with researchers at Johns Hopkins University in Baltimore.



I Wish You Knew

How cancer patients have changed my life

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More