Sunday, June 6, 2004

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OncoLink's ASCO Coverage made possible by an unrestricted Educational Grant from Bristol-Myers Squibb Oncology.

A prospective randomized trial of adjuvant vinorelbine and cisplatin in completely resected stage IB and II non-small cell lung cancer. Intergroup JBR10 Presenter: Timothy WintonPresenter's Affiliation: National Cancer Institute of CanadaType of Session: ScientificBackground Recent studies have shown that adjuvant chemotherapy following complete resection of non-small cell lung cancer (NSCLC)...
Cognitive function, fatigue and menopausal symptoms in women following adjuvant chemotherapy for breast cancer: One and two year follow-up of a prospective controlled study Presenter: N. TchenPresenter's Affiliation: Princess Margaret Hospital, Toronto, CAType of Session: ScientificBackground Adjuvant chemotherapy is given to many beast cancer patients; however, it can result in significant toxicity A previous report...
Comparison of outcomes of phase II trials (P2Ts) and subsequent randomized control trials (RCTs) using identical therapeutic regimens Presenter: M.I. ZiaPresenter's Affiliation: Princess Margaret Hospital, Toronto, ON, CanadaType of Session: ScientificBackground Phase I, Phase II and Phase III clinical trials represent the paradigm of clinical drug development. Phase I...
Does the addition of chemotherapy (CT) to preoperative radiotherapy (preopRT) increase the pathological response in patients with resected rectal cancer: Report of the 22921 EORTC phase III trial. Presenter: J.-F. BossetPresenter's Affiliation: Besancon University Hospital, Besancon, FranceType of Session: ScientificBackground Preoperative radiation treatment is used frequently in cases of resectable rectal cancer due to the advantages of...
Expanded access program (EAP) to investigational drugs Presenter: L. TalaricoPresenter's Affiliation: Food and Drug Administration, Rockville, MDType of Session: ScientificBackground Unapproved drugs which have shown evidence of clinical activity during the conduct of registration trials can...
Induction chemotherapy followed by concominant chemoradiotherapy (CT/XRT) versus CT/XRT alone for regionally advanced unresectable non-small cell cancer: Initial analysis of a randomized phase III trial Presenter: Everett V. VokesPresenter's Affiliation: Cancer and Leukemia Group BType of Session: ScientificBackground Induction chemotherapy has been shown to improve survival in patients with stage IIIB non-small cell lung cancer (NSCLC) compared...
Interim report of the JROSG99-1 multi-institutional randomized trial, comparing radiosurgery alone vs. radiosurgery plus whole brain irradiation for 1-4 brain metastases. Presenter: H. AoyamaPresenter's Affiliation: University School of Medicine, Sapporo, JapanType of Session: ScientificBackground Whole brain irradiation has long been the standard of care for the treament of multiple brain metastases. ...
Irinotecan plus fluorouracil/leucovorin (IFL) verus fluorouracil/leucovorin alone (FL) in stage III colon cancer (intergroup trial CALGB C89803) This presentation discusses an off-label use of irinotecan in the treatment of colon cancer. Presenter: L.B. SaltzPresenter's Affiliation: CALGBType of Session: ScientificBackground Metastatic colorectal cancer is a disease in which the natural...
June 6 Highlights Today, on this anniversary of D-Day, ASCO was bursting with new information and data. Details of presentations can be found on OncoLink for CME credit, but below is a brief summary of major themes discussed. HEMATOLOGIC MALIGNANCIES There were a...
Long-term use of NSAID reduces the risk of oral cancer Presenter: J. SudboPresenter's Affiliation: Norwegian Radium Hosptial, Oslo, NorwayType of Session: ScientificBackground Oral cavity cancers are often associated with high rates of morbidity and mortality COX-2 may play a role in the development...
Outcome of patients with advanced gastro-intestinal stromal tumors (GIST) crossing over to a daily imatinib dose of 800mg (HD) after progression on 400 mg (LD)- an international, intergroup study of the EORTC, ISG and AGITG This presentation discusses the use of imatinib at a dose that has not been approved by the FDA. Presenter: J.R. ZalcbergPresenter's Affiliation: EORTC/ ISG/AGITGType of Session: ScientificBackground This international intergroup has previously...
Randomized clinical trial of adjuvant chemotherapy with paclitaxel and carboplatin following resection in Stage IB non-small cell lung cancer: Report of Cancer and Leukemia Group B (CALGB) Protocol 9633 Presenter: Gary M. StraussPresenter's Affiliation: Cancer and Leukemia Group BType of Session: ScientificBackground The role of adjuvant chemotherapy for early stage non-small cell lung cancer (NSCLC) has been controversial Recently reported...
Report card for accelerated FDA approval oncology drugs (1995-2003): is it time for a make-up test? Presenter: S.M. BelknapPresenter's Affiliation: Northwestern University, Chicago, ILType of Session: ScientificBackground The FDA approval process includes multiple pathways. One of these is the accelerated approval that was adopted...
Sentinel node staging of resectable colon cancer: Results of the CALGB 80001. Presenter: M. M. BertagnolliPresenter's Affiliation: Brigham and Women's Hospital, Boston, MAType of Session: ScientificBackground The most important predictor of outcome in resected colon cancer is the locoregional nodal status. ...
Traditional versus up-front 18-FDG PET staging of non-small cell lung cancer (NSCLC): A Dutch Co-operative randomized study Presenter: G.J. HerderPresenter's Affiliation: POORT Study Group, NetherlandsType of Session: ScientificBackground The use of FDG-PET scan as an add-on study in non-small-cell-lung-cancer (NSCLC) patients scheduled to undergo surgery has been shown...