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Abramson Cancer CenterSaturday, May 14, 2005
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OncoLink coverage of the Annual Meeting of the American Society of Clinical Oncology, May 13-17, 2005, in Orlando, FL. OncoLink reporters provide in-depth, up-to-the-minute coverage of sessions and presentations.
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A Randomized Phase III Trial Comparing Bexarotene/Carboplatin/Paclitaxel vs. Carboplatin/Paclitaxel in Chemotherapy-Naive Patients with Advanced or Metastatic NSCLC (SPIRIT II Trial)
Presenter: G.R. Blumenschein, Jr., MDPresenter's Affiliation: SPIRIT II Trial GroupType of Session: ScientificBackground High RXR-beta expression has been shown to be correlated with increased survival in patients with non-small cell lung cancer... |
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A randomized, double-blind, placebo controlled, phase III study in patients (Pts) with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5-fluorouracil/leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1).
Presenter: J.R. HechtPresenter's Affiliation: UCLA School of Medicine, Los Angeles, CaliforniaType of Session: PlenaryBackground - A potential method for inhibiting tumor growth is to block a tumor's production of blood vessels (angiogenesis)... |
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Comparison of BEACOPP and ABVD chemotherapy in intermediate stage Hodgkin's lymphoma: Results of the fourth interim analysis of the HD11 trial of the GHSG
Presenter: B.C. KlimmPresenter's Affiliation: German Hodgkin's Study Group (GHSG)Type of Session: ScientificBackground - Combined modality therapy with 4-6 cycles ABVD and Involved Field Radiation (IFRT) is the standard of care for early, unfavorable... |
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E2197: Phase III AT (doxorubicin/docetaxel) vs. AC (doxorubicin/cyclophosphamide) in the adjuvant treatment of node positive and high risk node negative breast cancer
Presenter: L.J. GoldsteinPresenter's Affiliation: Fox Chase Cancer Center, Philadelphia, PennsylvaniaType of Session: KeynoteBackground A number of recent studies have shown the benefit of taxane based chemotherapy given in combination with other... |
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Erlotinib plus gemcitabine compared to gemcitabine alone in patients with advanced pancreatic cancer. A phase III trial of the National Cancer Institute of Cancada Clinical Trials Group (NCIC-CTG)
Presenter: M.J. MoorePresenter's Affiliation: NCICType of Session: PlenaryBackground Advanced and metastatic pancreatic cancer has an extremely poor prognosis, with median survival times between 4-6 months. Multiple attempts at combination... |
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First results of the EORTC-GELA H9 randomized trials: the H9-F trial (comparing 3 radiation dose levels) and H9-U trial (comparing 3 chemotherapy schemes) in patients with favorable of unfavorable early stage Hodgkin's lymphoma (HL)
Presenter: E.M. NoordijkPresenter's Affiliation: EORTCType of Session: ScientificBackground Hodgkin's lymphoma (HL) has an excellent prognosis, yet optimal therapy has still yet to be found Patients are treated based on known prognositc factors... |
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Gene expression profiles predict pathologic complete response to preoperative chemotherapy with gemcitabine, epirubicin, and docetaxel in primary breast cancer.
Presenter: A. SchneeweissPresenter's Affiliation: German Cancer Research Center, Heidelberg, GermanyType of Session: ScientificBackground - One of the benefits of using preoperative chemotherapy for... |
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HD10: Investigating reduction of combined modality treatment intensity in early stage Hodgkin's Lymphoma. Interim analysis of a randomized trial of the German Hodgkin's Study Group (GHSG)
Presenter: V. DiehlPresenter's Affiliation: German Hodgkin's Study GroupType of Session: ScientificBackground Patients with early stage Hodgkin's lymphoma (HL) have an excellent prognosis This is especially true in patients without risk factors,... |
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High-dose bevacizumab improved survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group (ECOG) study E3200
Presenter: Bruce GiantonioPresenter's Affiliation: University of PennsylvaniaType of Session: PlenaryBackground Bevacizumab (BEV) is a recombinant humanized monoclonal antibody which binds VEGF A. Half life is 17-21 days. 40-60% of... |
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Long-term survival results of a randomized multinational phase 3 trial of dacarbazine (DTIC) with or without Bcl-2 antisense (oblimersen sodium) in patients with advanced malignant melanoma
Presenter: J.M. KirkwoodPresenter's Affiliation: University of Pittsburgh Cancer InstituteType of Session: ScientificBackground Oblimersen sodium (Genasense, G3139) is an antisense oligonucleotide that selectively targets and specifically... |
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Molecular Analysis of the IDEAL/INTACT trials: EGFR Mutations and Gene Amplification
Presenter: T.J. LynchPresenter's Affiliation: Massachusetts General Hospital Cancer CenterType of Session: ScientificBackground Previous studies have shown that patients with non-small cell lung cancer (NSCLC) who have mutations in the gene for... |
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Paclitaxel and gemcitabine vs. carboplatin and gemcitabine. A multicenter, phase III randomized trial in patients with advanced inoperable non-small cell lung cancer (NSCLC)
Presenter: P.A. KosmidisPresenter's Affiliation: Hellenic Cooperative Oncology GroupType of Session: ScientificBackground Early phase data has shown the combination of paclitaxel and gemcitabine may be as active and well tolerate as the... |
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Randomized phase II/III trial of paclitaxel (P) plus carboplatin with or without bevacizumab (NSC #704865) in patients with advanced non-squamous non-small cell lung cancer (NSCLC): An Eastern Cooperative Oncology Group (ECOG) Trial - E4599
Presenter: A.B. SandlerPresenter's Affiliation: Easteran Cooperative Oncology GroupType of Session: PlenaryBackground The standard therapy for patients with advanced NSCLC is platinum-containing doublet chemotherapy. Randomized trials of targeted... |
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Randomized phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC).
Presenter: B. EscudierPresenter's Affiliation: Institut Gustave Roussy, Villejuif, FranceType of Session: ScientificBackground - Sorafenib (BAY 43-9006) is an oral inhibitor of a number of tyrosine... |
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Statins reduce the incidence of lung cancer: A study of half a million U.S. veterans.
Presenter: V. KhuranaPresenter's Affiliation: VA Medical Center, Shreveport, LouisianaType of Session: ScientificBackground - Statins (HMG CoA reducatse inhibitors) are a widely studied, effective class... |
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