Last Modified: September 14, 2003
Dear OncoLink "Ask The Experts,"
I had a total hysterectomy in 1999 for persistent CIN III, despite 2 LEEPs. The post-op cervical biopsy failed to reveal "clear borders." My subsequent vaginal biopsies have all returned with "inflammatory changes" until last month, when it showed vaginal dysplasia. What treatment is advised for this?
Christina S. Chu, MD, Assistant Professor of the Division of Gynecologic Oncology at the University of Pennsylvania Health System, responds:
Vaginal dysplasia may occur in patients treated for cervical dysplasia or cervical cancer. A prior history of cervical dysplasia does not affect treatment recommendations for new vaginal dysplasia. Treatment options include excision, laser ablation, or application of topical 5-fluorouracil cream.
Oct 11, 2012 - A new candidate vaccine designed to prevent cervical dysplasia and cancer in women already infected with human papillomavirus serotypes 16 and 18 is well tolerated and induces a robust immune response, according to a phase 1 study published in the Oct. 10 issue of Science Translational Medicine.
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