"MacDonald Option" in Radiation Therapy

Last Modified: April 2, 2006

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Question

Dear OncoLink "Ask The Experts,"

A friend was told that he would be treated for cancer using the "MacDonald option". Could you please elaborate?

Answer

Richard Whittington, MD, Associate Professor of Radiation Oncology at the University of Pennsylvania School of Medicine, responds:

It would be helpful to know the primary tumor type with which your friend was diagnosed. If it is gastric carcinoma, then the MacDonald regimen refers to Intergroup study INT0116. This was the randomized trial testing no adjuvant therapy (no therapy in addition to surgery) vs. adjuvant chemotherapy with 5-FU/FH4, followed by radiation with continuous infusion 5-FU, followed by more 5-FU/FH4. This study showed a significant improvement in overall survival for those patients who were treated with the adjuvant therapy. Jack MacDonald was the lead investigator of this study, and so this treatment is also referred to as the MacDonald regimen.


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Dec 7, 2010 - Rituximab may be a better option than watchful waiting in some lymphoma patients, and a new treatment option appears effective for relapsed or refractory Hodgkin's lymphoma, according to two studies being presented at the annual meeting of the American Society of Hematology, held from Dec. 4 to 7 in Orlando, Fla. Other research being presented will highlight new options for the standard treatment of advanced asymptomatic follicular lymphoma; mantle cell lymphoma; and early, unfavorable Hodgkin's disease.



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