Dear OncoLink "Ask The Experts,"
I am a 4th-year pharmacy student working on a project for a chemotherapy pharmacist. We are looking for a chart that shows [in] what order chemotherapy agents should be administered. Do you have any advice/resources for us?
Michael Vozniak, PharmD, BCOP, Hematology/Oncology Clinical Pharmacy Specialist, responds:
I think the best or correct order for drug administration is very regimen-specific (if it’s even important at all). So, it is tough to say for given chemo x and chemo y to always give them in a certain order. However, there are certain principles one can follow. For example, when giving a taxane in combination with a platinum, the taxane should always be given first. This is because it has been observed that if you give the platinum and then taxane, patients experience increased myelosuppression.
For some chemotherapy regimens, the original research articles will state the order in which they were administered, but this is rare.
See this related question about R-CHOP administration.
Dec 7, 2010 - Rituximab may be a better option than watchful waiting in some lymphoma patients, and a new treatment option appears effective for relapsed or refractory Hodgkin's lymphoma, according to two studies being presented at the annual meeting of the American Society of Hematology, held from Dec. 4 to 7 in Orlando, Fla. Other research being presented will highlight new options for the standard treatment of advanced asymptomatic follicular lymphoma; mantle cell lymphoma; and early, unfavorable Hodgkin's disease.
Dec 20, 2010