|Abramson Cancer Center of the University of Pennsylvania|
| Last Modified: November 1, 2001
History of Present Illness
Past Medical History
Past Surgical History
Medications and Allergies
Review of Systems
DIAGNOSTIC STUDIES: He undergoes a craniotomy and surgical resection of the tumor without complications. Pathology of the specimen reveals a glioblastoma multiforme, with hyperchromatic, highly pleomorphic cells palisading around areas of alternating necrosis and hypervascularity.
Assessment and Plan
C.D. is a 62-year-old Caucasian male with a relatively short course of symptoms prior to his presentation. His development of expressive aphasia and mood disturbances over a relatively brief time period are all worrisome for central nervous system neoplasia. Imaging confirms the presence of a brain tumor, prompting surgery for both diagnostic and therapeutic purposes. Following his craniotomy alone, his memory and speech have improved, although his comprehension remains variable.
Given the pathology of glioblastoma multiforme that was established following surgical resection of the left-sided frontal tumor, he would probably benefit from post-operative radiation therapy to 6000 cGy in approximately 30 fractions. He is also a candidate for the CAI protocol, which is a phase II NABTT study studying CAI, an angiogenesis inhibitor. The risks, benefits and procedures are explained to the patient and his family.
Given the weight of the diagnosis that he has just received today, the patient wishes to think about his options and have further discussion regarding post-operative adjuvant therapy.
Glioblastoma multiforme (GBM) and anaplastic astrocytomas are the most common primary brain tumors of adults. The optimal treatment schema includes a maximally safe resection and post-operative radiotherapy. The extent of surgical resection is dictated largely by the location of the tumor. Nondominant frontal lobe tumors can be extensively debulked, whereas tumor in the basal ganglia or thalamus generally can not be as effectively managed.
Treatment with surgery and adjuvant radiation therapy prolongs life but is seldom curative. For patients with glioblastomas, median survival is approximately 10 months, whereas for those with anaplastic astrocytomas, median survival is approximately 2 to 3 years.
With regards to chemotherapy, glioblastomas and anaplastic astrocytomas sometimes respond to BCNU, CCNU, and other nitrosoureas; procarbazine; and the new orally administered alkylating agent temozolomide. These tumors, however, tend to be substantially more resistant to chemotherapy than lymphomas, medulloblastomas, oligodendrogliomas, or germ-cell tumors.
Adjuvant chemotherapy with a nitrosurea or PCV has been shown to increase 1- and 2-year survival rates in patients with GBM or anaplastic astrocytoma by up to 10%. Some believe that anaplastic astrocytomas are more responsive to chemotherapy than are GBMs and recommend adjuvant PCV for young patients with good performance status and intermediate-grade gliomas.
For glioblastoma multiforme, the cure rate is very low with standard local treatment. These patients are appropriate candidates for clinical trials designed to improve local control by adding newer forms of treatment to standard treatment.
Standard Treatment Options:
Under clinical evaluation:
Patients with brain tumors that are either infrequently curable or unresectable should be considered candidates for clinical trials that evaluate the following: hyperfractionated irradiation, accelerated fraction irradiation, stereotactic radiosurgery, radiosensitizers, hyperthermia, interstitial brachytherapy, and intraoperative radiation therapy in conjunction with external-beam radiation therapy. This last technique may be used to improve local control of the tumor and/or for studies that evaluate new drugs and biological response
modifiers following radiation therapy [3, 4, 5, 6]. Cooperative group studies that evaluate hyperfractionated irradiation and interstitial brachytherapy are in progress . Finally, BCNU (carmustine)-impregnated polymer may be implanted during surgery as adjuvant therapy [8,9].
1. Shapiro WR: Therapy of adult malignant brain tumors: what have the clinical trials taught us? Seminars in Oncology 13(1): 38-45, 1986.
2. Rodriguez L, Levin V: Does chemotherapy benefit the patient with a central nervous system glioma? Oncology (Huntington NY) 1(9): 29-36, 1987.
3. Leibel SA, Gutin PH, Sneed PK, et al.: Interstitial irradiation for the treatment of primary and metastatic brain tumors. Cancer: Principles and Practice of Oncology Updates 3(7): 1-11, 1989.
4. Nelson DF, Urtasun RC, Saunders WM, et al.: Recent and current investigations of radiation therapy of malignant gliomas. Seminars in Oncology 13(1): 46-55, 1986.
5. Loeffler JS, Alexander E, Shea WM, et al.: Radiosurgery as a part of the initial management of patients with malignant gliomas. Journal of Clinical Oncology 10(9): 1379-1385, 1992.
6. Fontanesi J, Clark WC, Weir A, et al.: Interstitial iodine 125 and concomitant cisplatin followed by hyperfractionated external beam irradiation for malignant supratentorial glioma. American Journal of Clinical Oncology 16(5): 412-417, 1993.
7. Scharfen CO, Sneed PK, Wara WM, et al.: High activity iodine-125 interstitial implant for gliomas. International Journal of Radiation Oncology, Biology, Physics 24(1): 583-591, 1992.
8. Brem H, Piantadosi S, Burger PC, et al.: Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. Lancet 345(8956):1008-1012, 1995.
9. Brem H, Ewend MG, Piantadosi S, et al.: The safety of interstitial chemotherapy with BCNU-loaded polymer followed by radiation therapy in the treatment of newly diagnosed malignant gliomas: phase I trial. Journal of Neuro-Oncology 26(2): 111-123, 1995.