|H. van der Maase, S. W. Hansen, J.T. Roberts, et al.|
|Abramson Cancer Center of the University of Pennsylvania|
| Last Modified: November 1, 2001
Reviewers: Li Liu, MD
Précis: Gemcitabine plus cisplatin should become the standard for some bladder cancer patients
IntroductionThe standard therapy for many patients with advanced bladder cancer has been the combination of methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC). However, this regimen is associated with serious toxicity and patients with poor performance status have minimal benefit from intensive MVAC therapy. In this study, the researchers compared a new regimen using gemcitabine and cisplatin (GC) with the MVAC regimen to evaluate the clinical outcome in patients with bladder cancer.
MethodIn this study, 405 bladder cancer patients were randomized to either the GC or MVAC treatment groups.
DiscussionIn this study, patients with locally advanced or metastatic bladder cancer, switching from the standard MVAC chemotherapy to gemcitabine plus cisplatin achieved the same clinical benefits while significantly improving safety and tolerability. More studies are needed to further improve the response rate and survival in patients with advanced bladder cancer.