|Predictors of Progression to Cancer in Barrett's Esophagus: Baseline Histology and Flow Cytometry Identify Low-and High-Risk Patient Subsets|
|Brian J. Reid, Douglas S. Levine, Gary Longton, et al.|
|Abramson Cancer Center of the University of Pennsylvania|
| Last Modified: November 1, 2001
Reviewers: Li Liu, MD
Barrett's esophagus is a complication of gastroesophageal reflux disease in which metaplastic epithelium replaces the normal squamous lining. The significance of Barrett's lies in its potential to develop into adenocarcinoma. Virtually all cases of adenocarcinoma of the esophagus occur in the setting of Barrett's esophagus. In this study, the researchers attempted to identify patient subsets at low and high risk for progression to cancer.
Materials and Methods
A total of 322 patients with Barrett's esophagus were evaluated using endoscopic biopsy.
In this study, aneuploidy, increased 4N fractions, or high-grade dysplasia identified by endoscopic biopsy were associated with high risk of progression to cancer in patients with Barrett's esophagus. A better estimate of the incidence of adenocarcinoma in Barrett's esophagus is important, primarily to define appropriate clinical surveillance guidelines.