|George J. Tsioulias, Thomas F. Wood, Donald L. Morton, et al|
|Abramson Cancer Center of the University of Pennsylvania|
| Last Modified: November 1, 2001
Reviewers: Li Liu, MD
Précis: Sentinel node analysis increased detection of gastrointestinal cancer micrometastasis
IntroductionA sentinel lymph node (SLN) is the first lymph node along the route of lymphatic drainage from a primary tumor. Sentinel lymph nodes receiving lymphatic drainage from a tumor can be removed by limited surgery and examined to determine whether more extensive lymph node dissection is necessary. Sentinel lymph node biopsy carries lower morbidity and cost than a complete lymph node dissection. In this study, the researchers evaluated the feasibility of lymphatic mapping including SLN biopsy in gastrointestinal (GI) malignancies.
MethodA total of 65 patients with GI cancers were tested using intraoperative lymphatic mapping and sentinel lymphadenectomy.
DiscussionIn this study of patients with gastrointestinal cancers, lymphatic mapping and sentinel lymphadenectomy was feasible and accurately predicted the tumor status of regional lymph nodes, and identified abnormal lymphatic drainage. This is an important extension of the clinical application of sentinel node sampling. We should expect to see this technique used in a variety of tumors in different portions of the body.