UI - 11444705
AU - Brunelli JP; Robison BD; Thorgaard GH
Ancient and recent duplications of the rainbow trout Wilms' tumor gene.
SO - Genome 2001 Jun;44(3):455-62
AD - School of Biological Sciences, Washington State University, Pullman
The Wilms' tumor suppressor (WT1) gene plays an important role in the
development and functioning of the genitourinary system, and mutations
in this gene are associated with nephroblastoma formation in humans.
Rainbow trout (Oncorhynchus mykiss) is one of the rare animal models
that readily form nephroblastomas, yet trout express three distinct WT1
genes, one of which is duplicated and inherited tetrasomically. Sequence
analyses suggest an ancient gene duplication in the common ancestor of
bony fishes resulted in the formation of two WT1 gene families, that
conserve the splicing variations of tetrapod WT1, and a second
duplication event occurred in the trout lineage. The WT1 genes of one
family map to linkage groups 6 and 27 in the trout genome map. Reverse
transcribed polymerase chain reaction (RT-PCR) expression analysis
demonstrated little difference in W
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