- A necropsy case of Denys-Drash syndrome with a WT1 mutation in exon 7.
- Wilms' tumor: a paradigm for the new genetics.
Table of Contents
1
UI - 12161615
AU - Fukuzawa R; Sakamoto J; Heathcott RW; Hata JI
TI -
A necropsy case of Denys-Drash syndrome with a WT1 mutation in exon 7.
SO - J Med Genet 2002 Aug;39(8):e48
AD - Department of Pathology, Keio University School of Medicine, 35
Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
ryuji.fukuzawa@stonebow.otago.ac.nz
2
UI - 11939407
AU - Malik K; Yan P; Huang TH; Brown KW
TI -
Wilms' tumor: a paradigm for the new genetics.
SO - Oncol Res 2000;12(11-12):441-9
AD - University of Bristol, Department of Pathology and Microbiology, School
of Medical Sciences, University Walk, UK. k.t.a.malik@bris.ac.uk
Carcinogenesis can be triggered by a diverse range of molecular lesions,
a variety of which can be illustrated by Wilm's tumor (WT), a pediatric
kidney cancer. Molecular defects observed in WTs include several
independent targets and mechanisms best exemplified by changes on the
short arm of chromosome 11. This article will review the molecular
pathology of WT and emphasize the broader ramifications for cancer
genetics. Consideration will be given to carcinogenic pathways, novel
cellular molecules, and technologies that will assist in the rapid
interpretation and assimilation of DNA sequence data arising from the
sequencing of the human genome.
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