Paulo M. Hoff, Vicente Valero, Aman U Buzdar, et al.
Abramson Cancer Center of the University of Pennsylvania
Last Modified: November 1, 2001
Reviewers: Li Liu, MD
Source: Cancer Volume 88, 2054-2060 (May) 2000
Locally advanced breast cancers (LABC) are defined as tumors that measure more than 5 cm, tumors that extend to the chest wall or skin, and tumors with fixed ipsilateral axillary nodes or ipsilateral internal mammary nodes. A multimodality approach has been the treatment of choice for the patients with LABC. However, for elderly patients or patients with severe comorbid conditions, aggressive treatments can be difficult to tolerate. In this study, the researchers evaluated the use of tamoxifen in conjunction with locoregional therapies for patients with LABC who were age > 75 years or who were younger but in poor medical condition.
A total of 47 patients, ages 48 to 86 years, were treated with neoadjuvant tamoxifen followed by surgery and radiotherapy. Adjuvant tamoxifen was given for 5 years or until disease recurrence when feasible.
Neoadjuvant tamoxifen was well tolerated in elderly or frail patients with locally advanced breast carcinoma. Such treatment was proven to be effective with a reasonable response rate and good overall survival for patients with estrogen receptor positive tumors. A larger randomized study is warranted.
Mar 17, 2010 - In patients with locally recurrent prostate cancer following radical prostatectomy, magnetic resonance-guided ablation using laser interstitial thermal therapy and cryoablation may be a feasible treatment, according to research presented at the Annual Scientific Meeting of the Society of Interventional Radiology, held from March 13 to 18 in Tampa, Fla. In addition, cryotherapy may be a feasible treatment for breast cancer patients who refuse surgery, according to other research presented at the conference.
Mar 17, 2010