Cervical Cancer

A Randomized Trial of Pelvic Radiation Therapy Versus No Further Therapy in Selected Patients with Stage IB Carcinoma of the Cervix after Radical Hysterectomy and Pelvic Lymphadenectomy: A Gynecologic Oncology Group Study Reviewers: John Han-Chih Chang, MD Background / Discussion / Critique Early stage cervical cancer has a very good prognosis treated with either surgery (radical hysterectomy - RH) or radiation therapy (RT). The standard of care has been radical...
Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer Reviewers: Kenneth Blank, MDSource: New England Journal of Medicine April 15, 1999IntroductionThe treatment of women with locally advanced cervical cancer is evolving. Radiotherapy and chemotherapy form the standard of care in the United States;...
Paclitaxel and Cisplatin as First-Line Therapy in Recurrent or Advanced Squamous Cell Carcinoma of the Cervix: A Gynecologic Oncology Group Study Reviewers: Li Liu, MDSource: Journal of Clinical Oncology, 17(9): 2676, September 1999BackgroundThis is a phase II study testing the efficacy and toxicity of paclitaxel and cisplatin in recurrent or advanced squamous cell carcinoma of the cervix. It...
PAPNET-Assisted Re-screening of Cervical Smears - Cost and Accuracy Compared with a 100% Manual Re-screening Strategy Reviewers: John Han-Chih Chang, MD and Kenneth Blank, MD Source: gynecological cancer screening. It can detect cervical cancer along with vaginal and endometrial malignancies. It has reduced the cancer-associated mortality in cervical cancer,...
Pelvic Radiation with Concurrent Chemotherapy Compared with Pelvic and Para-Aortic Radiation for High-Risk Cervical Cancer Reviewers: Kenneth Blank, MDSource: RTOG) to conduct a large randomized prospective trial of radiotherapy alone versus combined radiotherapy andchemotherapy.The results of this trial will be reported in the April 15, 1999 issue ofthe New England...
Pelvic Radiation with Concurrent Chemotherapy Compared with Pelvic and Para-Aortic Radiation for High-Risk Cervical Cancer Authors: Morris M, Eifel P, Jiandong L, et al. Source: N Engl J Med 1999; 340:1137-1143. Background Cervical cancers that are bulky, extend to parametrial/pelvic tissues and/or involve pelvic lymph nodes benefit from external-beam plus...
Randomized Comparison Of Fluorouracil Plus Cisplatin Versus Hydroxyurea As An Adjunct To Radiation Therapy In Stage IIB-IVA Carcinoma Of The Cervix With Negative Para-Aortic Lymph Nodes: A Gynecologic Oncology Group And Southwest Oncology Group Study Reviewers: John Han-Chih Chang, MD Source: Conclusion: This study demonstrates that for patients with locally advanced carcinoma of the cervix, the combination of 5-FU and CF with RT offers patients better PFS and overall survival than HU, and...
Randomized Comparison of Weekly Cisplatin or Protracted Venous Infusion of Fluorouracil in Combination with Pelvic Radiation in Advanced Cervix Cancer: A GOG study Source: J Clin Oncol. 2005 Nov 20;23(33):8289-95 Authors: Lanciano R, Calkins A, Bundy BN, Parham G, Lucci JA 3rd, Moore DH, Monk BJ, O'Connor DM. Background Concurrent chemoradiation is the standard of care in locally advanced cervical...
Vaginal Changes and Sexuality in Women with a History of Cervical Cancer Reviewers: Kenneth Blank, MD Source: New England Journal of Medicine, May 6, 1999 Vol. 340 No. 18 p. 1383IntroductionLocal treatment of cervical cancer often involves surgery, radiotherapy, or a combination of both treatments. For early stage...