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A Double-Blind comparison of Empirical Oral and Intravenous Antibiotic Therapy for Low-risk Febrile Patients with Neutropenia during Cancer Chemotherapy
Reviewers: Li Liu, MD Source: New England Journal of Medicine, Volume 341, No 5 (July), 1999BackgroundFever and neutropenia (low white count) are major complications among cancer patients treated with intensive cytotoxicchemotherapy. Serious and... |
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Comparative Pharmacology and Clinical Activity of Cisplatin and Carboplatin
Reviewers: John Han-Chih Chang, MDSource: Journal of Clinical Oncology 1999, Volume 17 (Number 1): pages 409 ? 422BackgroundPlatinum complexes were stumbled upon as anti-proliferative agents back in the mid-1960's in experiments utilizing bacteria. ... |
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Discrepances Between Meta-Analyses and Subsequent Large Randomized, Controlled Trials
Reviewers: Leonard A. Farber, M.D., and John Chang M.D. Source: The New EnglandJournal of Medicine, August 21, 1997 -- Volume 337, Number 8:536-542From the research center, Hôtel-Dieu de MontréalHospital, and the Department of... |
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Facile Detection of Mitochondrial DNA Mutations in Tumors and bodily Fluids
Reviewers: Li Liu, MD Source: Science, Volume 287(5460): 2017-2019, (March) 2000Précis: Bodily fluid testing may detect come cancersIntroductionAny non-invasive techniques that would aid early detection of cancers would clearly be welcomed.... |
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Journal Scan article by Ken Blank and John Chang
Grodstein, F, Stampfer, MJ, Colditz, GA, Et al.The New England Journal of Medicine June 19 1997 Vol. 336 No.25 The risks and benefits of prescribing estrogen with or without progestins to postmenopausal women have been debated for many years. The... |
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Severe Necrosis Due to Paclitaxel Extravasation: Case Report
Reviewers: Leonard A. Farber, M.D. and John Chang, M.D. Source: Pharmacotherapy 1997; 17(1):163-165Paclitaxel (Taxol) is an agent with antineoplastic properties that is derived from the bark of the Pacific yew tree, Taxus brevifolia. It has been... |
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The Attitudes of Patients With Advanced AIDS Toward Use of the Medical Futility Rationale in Decisions to Forgo Mechanical Ventilation
Reviewers: Li Liu, MD Source: Archives of Internal Medicine Volume 160:1597-1601, (June) 2000.Précis: Better physician-patient communication is needed for end-of-life care.IntroductionDuring the last decade or two, patients and their... |
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The Contamination Of Poliovirus Vaccines With Simian Virus 40 (1953 - 1963) And Subsequent Cancer Rates
Reviewers: John Han-Chih Chang, MD and Kenneth Blank, MD Source: Journal of the American Medical Association 1998; Volume 279 (4): pages 292 - 295.IntroductionSimian Virus 40 (SV40) has been implicated to have tumorgenic effects in rodent models.... |
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