Cancer News
OncoLink Cancer News - HealthDay


Bevacizumab Active in HIV-Linked Kaposi's Sarcoma

Monday, March 19, 2012 (Last Updated: 03/20/2012)

MONDAY, March 19 (HealthDay News) -- For patients with HIV-associated Kaposi's sarcoma (HIV-KS), bevacizumab is tolerated and induces a response in some patients, according to a study published online March 19 in the Journal of Clinical Oncology.

Thomas S. Uldrick, M.D., from the National Cancer Institute in Bethesda, Md., and colleagues assessed the tolerability and efficacy of bevacizumab in 17 patients with HIV-KS that progressed or did not regress during highly-active antiretroviral therapy. Bevacizumab was administered intravenously to eligible patients with HIV-KS on days one and eight and every three weeks thereafter.

The researchers note that the median number of bevacizumab cycles was 10, during a median follow-up of 8.3 months. Of the 16 patients eligible for assessment, three had a complete response, two had a partial response, nine had stable disease, and two had disease progression, for an overall response rate (complete and partial response) of 31 percent. Of the five responders, four had received previous chemotherapy for KS. Grade 3 to 4 adverse events at least possibly related to therapy included hypertension in seven patients, neutropenia in five, cellulitis in three, and headache in two.

"Overall, this study suggests that bevacizumab has utility in KS," the authors conclude.

One of the authors disclosed holding patents on certain anti-HIV drugs. Bevacizumab for the study was provided by Genentech.

Abstract
Full Text (subscription or payment may be required)

Specialties Hematology & Oncology
HIV & AIDS
Infectious Disease
Internal Medicine
Family Practice
Pharmacy

Copyright © 2012 HealthDay. All rights reserved.


I Wish You Knew

Getting through cancer treatment: tips from an oncology nurse

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More