Cancer News
OncoLink Cancer News - HealthDay


Adverse Prognostic Factor ID'd in Operable Breast Cancer

Tuesday, October 30, 2012 (Last Updated: 10/31/2012)

TUESDAY, Oct. 30 (HealthDay News) -- For women with operable breast cancer, moderate immunohistochemical expression of human epidermal growth factor receptor (HER)-2 (2+) without amplification of HER-2 (HER-2 2+/HER-2) is an adverse prognostic factor, according to a study published online Sept. 4 in The Oncologist.

Valentina Rossi, M.D., from the Institute for Cancer Research and Treatment in Candiolo, Italy, and colleagues compared the clinical outcomes of 1,150 women (median age, 58 years) with operable breast cancer who were not receiving adjuvant trastuzumab. Patients were stratified according to a common HER-2 testing algorithm.

Of the women, 40 percent were considered HER-2 0+; 39 percent were HER-2 1+; 10 percent were HER-2 2+/HER-2; and 11 percent were HER-2+ (3+ or HER-2+) by fluorescence in situ hybridization. The researchers found that, on multivariate analysis, a HER-2 2+/HER-2 status correlated with worse disease-free survival, compared with a HER-2 0 or 1+ status. A HER-2 2+/HER-2 status showed a time-dependent effect on the probability of disease-free survival, with an initial advantage that lessened every year by a factor of 1.649, compared with a HER-2+ status.

"A HER-2 2+/HER-2status is an adverse prognostic factor in patients with operable breast cancer," the authors write. "Because of suggestions from randomized trials that the benefits of adjuvant trastuzumab may not be limited to patients with HER-2+ tumors, patients with a HER-2 2+/HER-2status are ideal candidates for studies testing this hypothesis."

One author disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Specialties Hematology & Oncology
OBGYN & Women's Health
Nursing
Family Practice
Pathology
Geriatrics
Internal Medicine

Copyright © 2012 HealthDay. All rights reserved.


I Wish You Knew

Screening with Mammography: Looking at the Controversy

View More







OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More