Cancer News
OncoLink Cancer News - HealthDay


Fidaxomicin Ups Outcome of C. difficile-Tied Diarrhea in Cancer

Monday, June 10, 2013 (Last Updated: 06/11/2013)

MONDAY, June 10 (HealthDay News) -- For patients with cancer with Clostridium difficile-associated diarrhea (CDAD), fidaxomicin treatment is associated with improved outcomes compared with vancomycin treatment, according to research published online May 28 in the Journal of Clinical Oncology.

Oliver A. Cornely, M.D., from the University Hospital of Cologne in Germany, and colleagues conducted two double-blind trials involving 1,105 patients with CDAD, 183 of whom had cancer, to treatment with fidaxomicin or vancomycin.

The researchers found that the cure rate was lower and time to resolution of diarrhea (TTROD) was longer for patients with versus without cancer. Compared with vancomycin, fidaxomicin treatment correlated with significantly increased odds of cure (odds ratio, 2.0), reduced likelihood of recurrence (odds ratio, 0.37), and more frequent sustained response (odds ratio, 2.56). For those treated with vancomycin, the median TTROD was significantly longer in patients with versus without cancer (123 versus 58 hours), while with fidaxomicin treatment, the median TTROD was not significantly different for those with and without cancer (74 and 54 hours, respectively). Age, hypoalbuminemia, and cancer correlated inversely with clinical cure in multivariate analysis of the full modified intent-to-treat population. Vancomycin treatment significantly predicted recurrence. Low albumin correlated negatively and fidaxomicin correlated positively with improved cure among patients with cancer.

"For patients with cancer, fidaxomicin treatment was superior to vancomycin, resulting in higher cure and sustained response rates, shorter TTROD, and fewer recurrences," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Optimer Pharmaceuticals, which funded the study and manufactures fidaxomicin.

Abstract
Full Text (subscription or payment may be required)

Specialties Hematology & Oncology
Internal Medicine
Nursing
Family Practice
Geriatrics
OBGYN & Women's Health

Health News Copyright © 2013 HealthDay. All rights reserved.


I Wish You Knew

What every person should know when facing a cancer diagnosis

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More