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Low-Fat Fish Oil Diet Beneficial in Prostate Cancer

Thursday, November 21, 2013 (Last Updated: 11/25/2013)

THURSDAY, Nov. 21, 2013 (HealthDay News) -- In men with prostate cancer, a low-fat fish oil diet is associated with lower serum levels of pro-inflammatory molecules, changes in serum levels of omega fatty acids, and a lower measure of cancer growth, compared with a Western diet, according to a study published online Oct. 29 in Cancer Prevention Research.

Colette Galet, Ph.D., from the University of California in Los Angeles, and colleagues compared serum levels of fatty acids and pro-inflammatory eicosanoids as well as cell cycle progression score in men with prostate cancer who had been randomly assigned to a low-fat fish oil diet (20 percent of calories from fat) or a Western diet (40 percent of calories from fat) for four to six weeks.

The researchers found that men on the fish oil diet had significantly lower serum levels of omega-6 fatty acids and 15(S)-hydroxyeicosatetraenoic acid (HETE), higher serum levels of omega-3 fatty acids, and a significantly lower cell cycle progression score compared with men on a Western diet. Leukotriene B4 levels were similar in both groups.

"In conclusion, a low-fat fish oil diet resulted in decreased 15(S)-HETE levels and lower cell cycle progression score relative to a Western diet," Galet and colleagues write.

The study was the result of work supported with resources and the use of facilities at Myriad Genetics Laboratories.

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Specialties Hematology & Oncology

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