Cancer News
OncoLink Cancer News - HealthDay


Tadalafil Not Helpful for ED in Prostate CA Post-Radiotherapy

Wednesday, April 2, 2014 (Last Updated: 04/03/2014)

WEDNESDAY, April 2, 2014 (HealthDay News) -- Among men receiving radiotherapy for prostate cancer, daily use of tadalafil is not more effective than placebo in preventing erectile dysfunction, according to research published in the April 2 issue of the Journal of the American Medical Association.

Thomas M. Pisansky, M.D., of the Mayo Clinic in Rochester, Minn., and colleagues randomly assigned men undergoing external radiotherapy (63 percent) or brachytherapy (37 percent) for prostate cancer to either tadalafil (121 patients) or placebo (121 patients) for 24 weeks.

The researchers found that, between weeks 28 and 30, 79 percent (95 percent confidence interval [CI], 70 to 88 percent) of the tadalafil group and 74 percent (95 percent CI, 63 to 85 percent) of the placebo group retained erectile function (P = 0.49). At one year, no significant difference was observed between the groups. No significant difference was observed between the groups in overall sexual function or satisfaction. Partners of men receiving tadalafil did not report a significant effect on sexual satisfaction. Neither participants nor partners reported significant improvement in marital adjustment with the use of tadalafil.

"Among men undergoing radiotherapy for prostate cancer, daily use of tadalafil compared with placebo did not result in improved erectile function," the authors write.

Eli Lilly partially funded the study and supplied the study drug and placebo.

Abstract
Full Text (subscription or payment may be required)

Specialties Hematology & Oncology
Pharmacy
Radiology
Urology
Family Practice
Internal Medicine

Copyright © 2014 HealthDay. All rights reserved.


I Wish You Knew

Nutrition During Cancer Treatment

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More