Cancer News
OncoLink Cancer News - HealthDay


Drug Regimen Effective for Small-Cell Lung Cancer

-- A. Agrawal, PhD

Thursday, February 12, 2009

THURSDAY, Feb. 12 (HealthDay News) -- A 21-day regimen of irinotecan and carboplatin is effective and well-tolerated in treating extensive and relapsed small-cell lung cancer, according to the results of a study published online Feb. 9 in the Journal of Clinical Oncology.

As part of a phase II trial, Gigi Chen, M.D., from the University of California-Davis in Sacramento, and colleagues treated 40 patients with extensive small-cell lung cancer and no previous chemotherapy and 40 patients with relapsed small-cell lung cancer and previous chemotherapy to irinotecan and carboplatin every 21 days for up to six cycles.

The researchers note that three patients died due to treatment-related neutropenic sepsis. Patients with extensive small-cell lung cancer and no previous chemotherapy had a response rate of 65 percent, while patients with relapsed lung cancer and previous chemotherapy had a response rate of 50 percent, the investigators found. Both groups had a median survival of 10 months. The 14 patients with brain metastases had a response rate of 65 percent for intracranial disease. The most common grade 3 to 4 toxicities in both groups included neutropenia (54 percent of patients), thrombocytopenia (22 percent) and diarrhea (22 percent), the report indicates.

"In summary, the three-week regimen of irinotecan and carboplatin was relatively well tolerated and efficacious in patients with small-cell lung cancer, especially for relapsed disease and brain metastasis," Chen and colleagues conclude.

The study was supported by an academic grant and Pfizer.

Abstract
Full Text (subscription or payment may be required)

Specialties Cardiology
Diabetes & Endocrinology
Internal Medicine
Family Practice

Copyright © 2009 ScoutNews, LLC. All rights reserved.


I Wish You Knew

OncoLink/LIVESTRONG Care Plan

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More