Jacqui Tan, MD
OncoLink Assistant Editor
Last Modified: November 1, 2001
Presenter: LM Freedman
Affiliation: University of Texas M.D. Anderson Cancer Center
Breast cancers associated with a genetic predisposition (e.g., BRCA-1 & BRCA-2 mutations) may behave more aggressively than sporadically occurring tumors. In particular, they tend to present at higher grades, lack hormone receptors, and have mutations of other genes such as p53. One might then question whether patients carrying these mutations could be at an increased risk of loco-regional recurrence with breast conserving therapy (BCT).
Because of the unwieldy cost and effort to identify the small percentage (<10%) of patients at risk, a diagnosis of bilateral breast cancer with a positive family history was used as a surrogate for germline mutations. These patients were assessed for loco-regional recurrence rates with BCT.
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