Last Modified: August 21, 2011
Classification: Monoclonal Antibody
Cancer cells from some tumors (most commonly breast, prostate and lung cancers) can spread to the bone, which is called bone metastasis. These cancer cells cause breakdown or wearing away of normal bone. In turn, affected bones become more fragile; they may be painful and can even break due to the damage from the cancer cells. Denosumab is a type of monoclonal antibody, which is a medicine designed to target a specific protein or cell – in this case, the target is a protein called RANKL, which is necessary for bone breakdown. By targeting RANKL, denosumab inhibits bone breakdown.
Denosumab is given every 4 weeks by subcutaneous injection (given under the skin, similar to insulin). In addition, your healthcare provider will want you to take calcium and vitamin D supplements to help with your bone health and prevent your blood calcium levels from getting too low. Talk with your team about what doses are right for you. You should drink plenty of fluids while taking this medication. Try to drink 8-10 glasses of non-alcoholic, non-caffeinated liquids a day.
There are a number of things you can do to manage the side effects of Denosumab. Talk to your doctor or nurse about these recommendations. They can help you decide what will work best for you. These are some of the most common side effects:
Take anti-nausea medications as prescribed. If you continue to have nausea or vomiting, notify your doctor or nurse so they can help you manage this side effect. In addition, dietary changes may help. Avoid things that may worsen the symptoms, such as heavy or greasy/fatty, spicy or acidic foods (lemons, tomatoes, oranges). Try antacids, (e.g. milk of magnesia, calcium tablets such as Tums), saltines, or ginger ale to lessen symptoms. Read the Nausea & Vomiting Tip Sheet for more suggestions.
Call your doctor or nurse if you are unable to keep fluids down for more than 12 hours or if you feel lightheaded or dizzy at any time.
While on cancer treatment you may need to adjust your schedule to manage fatigue. Plan times to rest during the day and conserve energy for more important activities. Exercise can help combat fatigue; a simple daily walk with a friend can help. Talk to your healthcare team and see OncoLink's section on fatigue for helpful tips on dealing with this side effect.
Denosumab can cause your blood calcium levels to drop below normal. You will take calcium and vitamin D supplements to prevent the level from getting too low. Signs that calcium levels are low include: numbness or tingling sensation around the lips, muscle stiffness, twitching, spasms or cramps. Be sure to notify your oncology team if these symptoms occur.
Osteonecrosis of the jaw (ONJ) is a rare side effect, however, it is important that you know about it and take steps to protect your dental health. The maxilla (upper jaw bone) and mandible (lower jaw bone) are normally covered by gum tissue. In the case of ONJ, this tissue is gone and the bone is exposed. Typical symptoms associated with ONJ are: pain, swelling or infection of the gums, loosening of the teeth, exposed bone (often at the site of a previous tooth extraction). Some patients may report numbness or tingling in the jaw or a "heavy" feeling jaw. ONJ may have no symptoms for weeks or months and may only be recognized by the presence of exposed bone. ONJ most often occurs soon after a dental procedure, but this is not required for ONJ to occur.
Avoid any dental surgery or invasive dental procedures while on bisphosphonate therapy.
Feb 25, 2011 - The American Society of Clinical Oncology has issued updated guidelines for the use of bone-modifying agents in treating breast cancer patients with bone metastases to include a new drug, denosumab, and provide new advice regarding a potentially serious complication of treatment, osteonecrosis of the jaw; an overview of the guideline update has been published online Feb. 22 in the Journal of Clinical Oncology.
Feb 25, 2011
Feb 12, 2010