Last Modified: January 11, 2013
Pronounced: rux'' oh li' ti nib
Classification: Kinase Inhibitor
Ruxolitinib is a type of targeted therapy called a kinase inhibitor. This means it works by targeting receptors present on the cancer cells. Ruxolitinib targets Janus Associated Kinases, JAK1 and JAK2, which regulate cytokines and growth factors that are important for blood cell formation and immune function.
Ruxolitinib comes in a tablet form in multiple dosage strengths. It is typically taken twice a day, with or without food. The exact dose is based on your platelet count. Your blood counts will be monitored closely while on therapy and your dose will be adjusted based on the platelet count. If you miss a dose, do not take an additional dose to make up for the missed dose.
The blood levels of this medication can be affected by certain foods and medications, so they should be avoided. These include: grapefruit, grapefruit juice, dexamethasone, ketoconazole, rifampin, phenytoin, St. John’s wort, and many anti-fungal medications. Be sure to tell your healthcare provider about all medications and supplements you take.
Below are some of the possible side effects and suggestions for dealing with them. Be sure to tell your oncology team if you are experiencing any of these problems.
White blood cells (WBC) are important for fighting infection. While receiving treatment, your WBC count can drop, putting you at a higher risk of getting an infection. You should let your doctor or nurse know right away if you have a fever (temperature greater than 100.4¡), sore throat or cold, shortness of breath, cough, burning with urination, or a sore that doesn't heal.
Tips to preventing infection:
For more suggestions, read the Neutropenia Tip Sheet.
Your red blood cells are responsible for carrying oxygen to the tissues in your body. When the red cell count is low, you may feel tired or weak. You should let your doctor or nurse know if you experience any shortness of breath, difficulty breathing or pain in your chest. If the count gets too low, you may receive a blood transfusion. Read the anemia tip sheet for more information.
Platelets help your blood clot, so when the count is low you are at a higher risk of bleeding. Let your doctor or nurse know if you have any excess bruising or bleeding, including nose bleeds, bleeding gums or blood in your urine or stool. If the platelet count becomes too low, you may receive a transfusion of platelets.
Read the thrombocytopenia tip sheet for more information.
In studies, patients reported headaches and dizziness.