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NCI CANCERLIT^® Search: Li-Fraumeni Syndrome - September 2002

National Cancer Institute^®
Last Modified: September 1, 2002

Scientists screen embryo for genetic predisposition to cancer.
p53 modulation of TFIIH-associated nucleotide excision repair activity.

Table of Contents

1
UI - 11420261
AU - Gottlieb S
TI - Scientists screen embryo for genetic predisposition to cancer.
SO - BMJ 2001 Jun 23;322(7301):1505

2
UI - 7663514
AU - Wang XW; Yeh H; Schaeffer L; Roy R; Moncollin V; Egly JM; Wang Z;
TI - Freidberg EC; Evans MK; Taffe BG; et al p53 modulation of TFIIH-associated nucleotide excision repair activity.
SO - Nat Genet 1995 Jun;10(2):188-95
AD - Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.
p53 has pleiotropic functions including control of genomic plasticity and integrity. Here we report that p53 can bind to several transcription factor IIH-associated factors, including transcription-repair factors, XPD (Rad3) and XPB, as well as CSB involved in strand-specific DNA repair, via its C-terminal domain. We also found that wild-type, but not Arg273His mutant p53 inhibits XPD (Rad3) and XPB DNA helicase activities. Moreover, repair of UV-induced dimers is slower in Li-Fraumeni syndrome cells (heterozygote p53 mutant) than in normal human cells. Our findings indicate that p53 may play a direct role in modulating nucleotide excision repair pathways.

The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.

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