National Cancer Institute®
Last Modified: November 21, 2001
UI - 21256535
AU - Ota Y; Aoki T; Karakida K; Yamazaki H; Makuuchi H; Chino O; Miyasaka M
TI - Simultaneous treatment of multiple primary cancers of the oral cavity and other sites.
SO - Tokai J Exp Clin Med 2000 Dec;25(4-6):165-71
AD - Department of Oral Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Multiple primary cancers are not uncommon in the head and neck region. Since the time for treatment will be prolonged if each lesion is treated separately, simultaneous treatment of the cancers is preferred to ensure complete remission of lesions and increased survival of patients. In this paper, the efficacy of combined treatment was evaluated in 9 patients with oral cancers and concurrent cancers in other sites. The mean age of the patients was 54 years (range 44 to 66). The tongue (8) and mandible (1) were the sites of involvement. Concurrent cancers were found most often in the esophagus, followed by stomach and lung. Histologically, 7 lesions were diagnosed as squamous cell carcinomas. All oral cancers were treated by surgery. Neck dissection and simultaneous reconstruction were performed in 5 patients. In addition, concurrent cancers were treated simultaneously by endoscopic mucosal resection in 2 patients and radical resection followed by immediate reconstruction in 6 other patients. However, simultaneous surgical treatment of all lesions could not be performed in an individual with 3 cancers. The time of surgery ranged from 23 minutes to 17 hours and 30 minutes. With the exception of 2 patients who died of postoperative complications and had needed treatment for dysphasia, all patients were discharged after 1 to 2 months. Four of the patients are still alive 2 years and 6 months after surgery. These results indicate that simultaneous treatment is effective in selected cases of multiple cancers.
UI - 21256553
AU - Moore SR; Allister J; Roder D; Pierce AM; Wilson DF
TI - Lip cancer in South Australia, 1977-1996.
SO - Pathology 2001 May;33(2):167-71
AD - School of Dentistry, The University of Adelaide, South Australia, Australia.
Lip cancer (140 ICD-9, C00 ICD-10) is a form of oral cancer occurring at the junction between the oral cavity and the skin. Lip cancer has a distinctive global epidemiology that is notably different from cancer occurring at other intraoral sites. This study reviews and analyses the epidemiological data for lip cancer from the South Australian Central Cancer Registry between 1977 and 1996. During this 20-year period, 2716 cases of lip cancer (2095 male, 621 female) and 35 deaths from this disease (23 males, 12 females) were reported. The average age of diagnosis was 58.3 years in males and 66.0 years in females. Very high age-standardised incidence rates (over 15.0 per 100000 per annum in males and 4.0 per 100000 per annum in females) were found, giving the South Australian population amongst the highest incidence of lip cancer in the world. Also of considerable concern was the finding that, contrary to global trends, these rates showed a significant increase over the 20-year period in both sexes. Possible reasons for these findings are discussed.
UI - 21355891
AU - Sakazume S
TI - [Gingival multiple hamartoma syndrome]
SO - Ryoikibetsu Shokogun Shirizu 2001;(33):752-3
AD - Department of Pediatrics, Dokkyo University School of Medicine, Koshigaya Hospital.
UI - 21341673
AU - Baba Y; Tsukuda M; Mochimatsu I; Furukawa S; Kagata H; Nagashima Y;
TI - Koshika S; Imoto M; Kato Y Cytostatic effect of inostamycin, an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, on oral squamous cell carcinoma cell lines.
SO - Cell Biol Int 2001;25(7):613-20
AD - Department of Otolaryngology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.
Inostamycin, which was recently isolated from Streptomyces sp. MH816-AF15 as an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, caused a G1-phase accumulation in the cell cycle of small cell lung carcinomas. To investigate whether the cytostatic effect of inostamycin is restricted to lung carcinoma cell lines or applicable to other type of cells, we tested five oral squamous cell carcinoma (SCC) cell lines. Cell growth was suppressed in 62.5--125 ng/ml inostamycin in the culture medium in all oral cancer cell lines tested, with non-viable cells being <1%, indicating inostamycin is cytostatic on SCC cell lines. Decrease in cyclin D1 mRNA and protein expression due to the inostamycin treatment was accompanied by suppression of phosphorylated retinoblastoma susceptibility gene product (pRB-P) levels. Moreover, flow cytometric analysis showed that inostamycin induced an increase in G1/G0 cells (1.2--3.2 fold) over 24 h. These results suggest that inostamycin is a useful agent for tumour dormant cytostatic therapy for oral SCC. Copyright 2001 Academic Press.
UI - 21373588
AU - Banoczy J; Gintner Z; Dombi C
TI - [Effect of smoking on the development of oral leukoplakia]
SO - Fogorv Sz 2001 Jun;94(3):91-6
AD - Semmelweis Egyetem, Fogorvostudomanyi Kar, Oralbiologiai Tanszek, Budapest.
The increase in cancer mortality throughout the world justifies the study of its causes and development. Oropharyngeal cancer is ranked on the sixth place, Hungary with the highest mortality among 46 countries. Tobacco use is implicated in the development of oral cancer, and oral leukoplakia as well. The aim of the study was to give an overview on the connection between tobacco use and oral leukoplakia. Summarizing the literary data strong evidence has been found on the role of smoking in the development both of oral cancer and oral leukoplakia. Epidemiologic patterns of cigarette-smoking show a steep increase in Central-European countries, especially in Hungary. Cross-sectional studies indicate higher prevalence rate of leukoplakia among smokers, with a dose-response relationship between tobacco use and oral leukoplakia, while intervention studies show a regression of the lesion after stopping the smoking habit.
UI - 21396155
AU - Huang CJ; Chao KS; Tsai J; Simpson JR; Haughey B; Spector GJ; Sessions
TI - DG Cancer of retromolar trigone: long-term radiation therapy outcome.
SO - Head Neck 2001 Sep;23(9):758-63
AD - Radiation Oncology Center, Mallinckrodt Institute of Radiology Washington University Medical Center, 4939 Children's Place, Suite 5500, St. Louis, MO 63110, USA.
BACKGROUND: Cancer of the retromolar trigone is an uncommon head and neck cancer. In this retrospective study, we identified the prognostic factors and evaluated the therapeutic outcomes of patients treated with preoperative radiation therapy (RT), postoperative RT, and RT alone. METHODS: Between 1971 and 1994, 65 patients with histologically proven epidermoid carcinoma of the retromolar trigone were treated at the Mallinckrodt Institute of Radiology; 10 patients received preoperative RT (30-55.2 Gy), 39 received postoperative RT (46-66.6 Gy), and 15 were treated with RT alone (63-74 Gy). Surgery included 44 composite resections and 7 wide excisions. The minimum follow-up was 5 years. RESULTS: The 5-year disease-free survival rates were 90% with preoperative RT, 63% with postoperative RT, and 31% with RT alone. The 5-year disease-free survival rates were 76% for patients with T1 disease, 50% for T2, 72% for T3, and 54% for T4. The 5-year disease-free survival rates were 69% for patients with NO disease, 56% for N1, and 26% for N2. The locoregional recurrence rates were 10% (1 of 10) for preoperative RT, 23% (9 of 39) for postoperative RT, and 44% (7 of 16) for RT alone. On multivariate analysis, the significant factors for disease-free survival were treatment modality (p =.002) and N stage (p =.012); for locoregional control it was treatment modality (p =.046); and for distant metastasis it was N stage (p =.002). The incidence of bone necrosis, soft tissue necrosis, and severe trismus was 12% with postoperative RT, 11% with RT alone, and none with preoperative RT. CONCLUSIONS: Combination surgery with postoperative or preoperative RT offers better locoregional control and disease-free survival than RT alone for epidermoid carcinoma of the retromolar trigone. Lymph node status significantly influences the disease-free survival and distant metastasis rates. Copyright 2001 John Wiley & Sons, Inc.
UI - 21405186
AU - Varghese BT; Sebastian P; Cherian T; Mohan PM; Ahmed I; Koshy CM; Thomas
TI - S Nasolabial flaps in oral reconstruction: an analysis of 224 cases.
SO - Br J Plast Surg 2001 Sep;54(6):499-503
AD - Division of Surgical Oncology, Regional Cancer Centre, Trivandrum, Kerala.
The nasolabial flap is a simple option for the reconstruction of selected oral defects. Though its use in floor-of-mouth reconstruction has been described, other uses in the oral cavity have not been studied extensively. We present a series of 224 oral malignancies where the nasolabial flap was used for reconstruction after surgical excision. Copyright 2001 The British Association of Plastic Surgeons.
UI - 21421251
AU - Shiboski CH; Wilson CM; Greenspan D; Hilton J; Greenspan JS; Moscicki
TI - AB; Adolescent Medicine HIV/AIDS Research Network HIV-related oral manifestations among adolescents in a multicenter cohort study.
SO - J Adolesc Health 2001 Sep;29(3 Suppl):109-14
AD - Department of Stomatology, University of California at San Francisco, San Francisco, California 94143-0422, USA. email@example.com
PURPOSE: To describe baseline prevalence of oral mucosal diseases among HIV infected adolescents in relationship to biological and behavioral risk factors. METHODS: Participants in Reaching for Excellence in Adolescent Care and Health (REACH), a multicenter longitudinal observational study of HIV/AIDS in adolescents, received physical examinations, blood tests, and oral examinations at 3-month intervals. We evaluated participants for oral conditions commonly seen in relationship to HIV, and explored the association of the most common lesion with selected biological and behavioral variables at baseline using contingency tables and Fisher's Exact test. RESULTS: Among 294 HIV majority were female (75%), aged 17 to 18 years (69%), and African-American (73%). More than 90% had a CD4(+) T-lymphocyte count > 200 cells/mm(3) at baseline and 57% had a plasma HIV-1 RNA concentration
UI - 21437445
AU - O'Quinn RP; Stasko T
TI - Repair of the lower lip after Mohs micrographic surgery.
SO - Dermatol Surg 2001 Sep;27(9):845-7
AD - Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
UI - 21439129
AU - Shintani S; Mihara M; Terakado N; Nakahara Y; Matsumura T; Kohno Y;
TI - Ohyama H; McBride J; Kent R; Todd R; Tsuji T; Wong DT Reduction of p12DOC-1 expression is a negative prognostic indicator in patients with surgically resected oral squamous cell carcinoma.
SO - Clin Cancer Res 2001 Sep;7(9):2776-82
AD - Laboratory of Molecular Pathology, Division of Oral Pathology, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, MA 02115, USA.
PURPOSE: p12DOC-1 is a growth suppressor that negatively regulates cyclin-dependent kinase 2 (CDK2) activities. Expression of p12DOC-1 is reduced and/or lost in tumor tissues. The purpose of this study is to correlate in vivo the expression of p12DOC-1 in oral cancer tissues by immunohistochemistry with clinical and pathological parameters. EXPERIMENTAL DESIGN: Twenty-five cases of normal oral mucosa and 127 cases of oral squamous cell carcinomas were evaluated. Patients' charts were reviewed for clinical, pathological, and 10-year survival data. Because p12DOC-1 is a growth suppressor and associates with CDK2, parallel immunostaining was done for proliferating cell nuclear antigen and CDK2 to evaluate cell proliferation and potential correlation with CDK2. RESULTS: Our results showed that strong p12DOC-1 staining was uniformly seen in normal oral mucosa. p12DOC-1 staining was reduced or absent in 81 cases (63.8%) of oral squamous cell carcinomas. Decreased p12DOC-1 staining (<25% of cells stained) correlated with tumor mode of invasion (P = 0.001) and higher proliferating cell nuclear antigen (P = 0.0028) and CDK2 (P = 0.0020) expression. Survival analysis showed significant correlation of low p12DOC-1 expression with the risk of cervical lymph node metastasis (P = 0.001) and patients' 10-year survival status (P = 0.0214). CONCLUSIONS: These results allow us to conclude that reduction of p12DOC-1 protein expression is a frequent event in oral cancers. Intratumor immunohistochemical evaluation of p12DOC-1 expression can be an adjunctive prognostic indicator for patients with oral cancer.
UI - 21445200
AU - Haas KM; Berndt A; Stiller KJ; Hyckel P; Kosmehl H
TI - A comparative quantitative analysis of laminin-5 in the basement membrane of normal, hyperplastic, and malignant oral mucosa by confocal immunofluorescence imaging.
SO - J Histochem Cytochem 2001 Oct;49(10):1261-8
AD - Institute of Pathology, Friedrich Schiller University, Jena, Germany.
Laminin-5 (Ln-5) is a heterotrimeric basement membrane (BM) molecule (alpha3beta3gamma2). It is a principal protein constituent of the anchoring filaments, which connect the BM with the hemidesmosomes of the basal keratinocytes and possess a crucial function in keratinocyte adhesion. Confocal immunofluorescence imaging is introduced for a quantitative evaluation of the Ln-5 content in the BM of oral squamous epithelium. The BM of normal oral mucosa was used as a reference (100%) for comparative analysis and showed a nearly uniform Ln-5 immunofluorescence intensity (99-100%). In all hyperplastic lesions of oral mucosa, the Ln-5 immunofluorescence intensity was increased (107-141%). The increased Ln-5 content in the BM of hyperplastic lesions suggests an increased keratinocyte-BM adhesion, possibly resulting in a higher stability of the oral mucosa. In contrast, in the oral squamous cell carcinoma (OSCC) invasive front, the remaining BM segments were characterized by a decrease in Ln-5 immunofluorescence intensity (35-74%). A stronger decrease of Ln-5-linked kerationocyte-BM adhesion correlates with a higher tumor grade. Because in central areas of carcinoma BM segments with a normal Ln-5 content could be demonstrated, the fundamental Ln-5 diminution in BM segments of the invasive front should be considered as an invasion-associated phenomenon.
UI - 21425215
AU - Zein TM; Carlsen EJ; Mirghani ZM
TI - An unusual association between oral sarcoma and bulbar palsy.
SO - Saudi Med J 2000 Jan;21(1):88-9
AD - Department of Medicine, Armed Forces Hospital, Southern Region, PO Box 101, Khamis Mushayt, Kingdom of Saudi Arabia.
A 90 year old male presented with symptoms and signs of right lower cranial nerves palsy. A small mass was found on the right side at the back of his mouth. Light microscopy and histoimmunochemical studies of the biopsy of the mass showed an alveolar soft part sarcoma arising from the right myohyoid muscle. The unusual location and presentation of this rare tumor is discussed.
UI - 21373377
AU - Long Y; Ling D; Yue W
TI - [P53 expression and clinical significance in oral squamous cell carcinoma]
SO - Hua Xi Kou Qiang Yi Xue Za Zhi 1997 May;15(2):115-6, 122
AD - Stomatological Hospital, Shandong Medical University, China.
P53 protein expression was investigated in oral squamous cell carcinomas and oral premalignant lesions by monoclonal antibody Do-1 and immunohistochemistry technique. 4 of 12 (33.3%) samples of severe epithelial dysplasia and 25 of 44 (56.8%) samples of squamous cell carcinoma expressed P53 protein while all the normal mucosa, mild and moderate epithelial dysplasia were negative. The P53 expression in carcinomas was associated with differentiation, lymph node metastasis and tumour stage. This result indicated that P53 genic mutation might be an early event in oral mucosa carcinogenesis and related to oral tumor progression. Detection of P53 protein probably has clinical significance in identifying the premalignant lesions of oral mucosa and predicting the prognosis of oral carcinomas.
UI - 21373379
AU - Chen Q; Fu J; Yang G
TI - [A study on the significance of p53 gene mutation, P53 protein positive staining and PCNA staining]
SO - Hua Xi Kou Qiang Yi Xue Za Zhi 1997 May;15(2):119-22
AD - College of Stomatology, West China University of Medical Sciences.
After obtaining the results of p53 gene mutation by a silver staining method to polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis, P53 protein staining and proliferation cell nuclear antigen (PCNA) index by double-blind method, multivariate correlation analysis two by two showed that PCR-SSCP, P53 positive protein staining and PCNA index had markedly correlation not only in oral precancerous lesions (OPL) but also in primary sites and regional metastatic lymph nodes of oral squamous cell carcinomas (OSCC). This indicated that the nature of the three indexes was the same. After introducing the sex and age of patients which have been proved to be related to the initiation and development of OPL and OSCC according to other researchers and are easy to be obtained in clinics, multivariate discriminatory analysis was carried on and three groups of discriminatory equations were gotten about the pathological grading of OPL and OSCC and metastasis condition of OSCC. The accuracy of these equations was 82.5%, 78% and 80%, individually. This suggests that the equations have applicable potentiality already.
UI - 21373387
AU - Lu Y; Li C; Zhou Z
TI - [mRNA expression of metastasis-suppressor gene nm23 in carcinoma of buccal mucosa I. Northern blotting study]
SO - Hua Xi Kou Qiang Yi Xue Za Zhi 1997 May;15(2):143-6
AD - Department of Oral Pathology, College of Stomatology, West China University of Medical Sciences, China.
In this study the authors detected both nm23-H1 and nm23-H2 mRNA levels in 52 tissues samples of patients with carcinoma of buccal mucosa (CBM) by Northern blotting method. The expression levels of both nm23-H1 and nm23-H2 mRNA in CBM were higher than those in normal buccal mucosa, leukoplakia, adjacent nontumorous mucosa, and lymph nodes with or without metastasis. The nm23-H1 mRNA expression levels in CBM with lymph nodes metastases were lower than those in CBM without metastasis, and were lower in metastatic lympho nodes (P < 0.05). Of the 11 cases with metastases, 9 cases (81.8%) showed low expression of nm23-H1 mRNA, of 19 cases without metastasis, 15 cases (78.9%) were high expression. No significance of nm23-H2 mRNA expression levels were found between CBM with and CBM without metastasis (P > 0.05). The expression of nm23-H1 and nm23-H2 mRNA showed no significant correlation with each clinical-pathological parameter examed. The result suggested that the expression of nm23-H1 mRNA significantly correlated inversely with lymph node metastasis in CBM, while the expression of nm23-H2 mRNA not. nm23 mRNA expression levels can provide a valuable predictor of lymph node metastases in CBM.
UI - 21373388
AU - Gong L; He Z; Lu Y
TI - [mRNA expression of metastasis-suppressor gene nm23 in carcinoma of buccal mucosa. II. Quantitative reverse transcription PCR amplification]
SO - Hua Xi Kou Qiang Yi Xue Za Zhi 1997 May;15(2):147-50
AD - Department of Oral Pathology, College of Stomatology, West China University of Medical Sciences, China.
The nm23 gene is a conspicuous metastasis-suppressor gene. The authors detected both nm23-H1 and nm23-H2 mRNA levels in 47 tissues samples of patients with carcinoma of buccal mucosa (CBM) by quantitative reverse transcription PCR amplification. The results showed that expression levels of both nm23-H1 and nm23-H2 mRNA varied in normal buccal mucosa, leukoplakia, adjacent nontumorous mucosa, submandibular gland, CBM and lymph nodes with or without metastasis. The nm23-H1 mRNA expression levels in CBM with lymph nodes metastases were lower than those in CBM without metastases (P < 0.05), while no significance of nm23-H2 mRNA expression levels was found between CBM with and CBM without metastasis (P > 0.05). The results were comparative to those of Northern blotting of the same cases. The authors concluded that, as also in the study of Northern blotting, the expression of nm23-H1 mRNA significantly correlated inversely with lymph node metastasis in CBM, while the expression of nm23-H2 mRNA not. Q-RT-PCR was a useful method to detect the mRNA levels of nm23 gene in buccal carcinoma.
UI - 21365125
AU - Sanchez Sambucety P; Manchado Lopez P; Rodriguez Prieto MA; Ruiz
TI - Gonzalez I; Martinez Fernandez M [Whitish lesions in oral mucosa]
SO - An Esp Pediatr 2001 Aug;55(2):159-60
AD - Servicio de Dermatologia, Hospital de Leon, Leon.
Whitish lesions in oral mucosa are usually diagnosed as candidosis, lichen planus or dysplasias. However, other infrequent entities associated with leukoplakia should be borne in mind. We present the case of a 7-year-old girl with whitish lesions in the oral mucosa. Laboratory, mycological and histopathological investigations were performed and the patient was diagnosed with oral white sponge nevus.
UI - 21379671
AU - Verbin S
TI - Genetic influences in women's oral health.
SO - Dent Clin North Am 2001 Jul;45(3):443-67, v
AD - Department of Pediatrics, Prince William Hospital, Manassas, Virginia, USA. firstname.lastname@example.org
Variations in the genetic code have been described in an ever increasing array of conditions. This article focuses on a select group of disorders chosen for their relevance both to women and the dental practitioners who care for them. Many of these disorders also illustrate important advances in understanding the complex interaction between an individual's genetic code make-up and the surrounding environment.
UI - 21400262
AU - Said-Al-Naief N; Zahurullah FR; Sciubba JJ
TI - Oral spindle cell lipoma.
SO - Ann Diagn Pathol 2001 Aug;5(4):207-15
AD - Department of Pathology, the University of Alabama at Birmingham, AL 35294-0007, USA.
Lipoma is an uncommon benign, oral, soft-tissue neoplasm commonly found on the buccal mucosa. It is predominantly composed of mature fat with or without other mesenchymal tissue elements, showing a variety of histologic subtypes, one of which is the rare "spindle cell variant" with only nine previously reported cases in the English literature. In this report, we review clinical and histomorphologic data of 164 cases of oral lipomas retrieved from the files of Long Island Jewish Medical Center, Department of Dental Medicine (New Hyde Park, NY). Of these, only two cases were diagnosed as the spindle cell variant, further confirming the rarity of this histologic subtype. A review of oral lipoma with particular reference to the spindle cell variant is also presented.
UI - 21411333
AU - Lessard JL; Robinson RA; Hoffman HT
TI - Differential expression of ras signal transduction mediators in verrucous and squamous cell carcinomas of the upper aerodigestive tract.
SO - Arch Pathol Lab Med 2001 Sep;125(9):1200-3
AD - Department of Pathology, University of Iowa, Iowa City, IA 52243, USA.
CONTEXT: ras gene mutations and expression of its gene product have been described in verrucous and squamous cell carcinomas. Other downstream signal-transduction mediators, extracellular signal-regulated kinases 1 and 2 (ERK-1 and ERK-2) and Raf-1, have not yet been as extensively studied. OBJECTIVE: To determine patterns of expression of ERK-1, ERK-2, and Raf-1 in verrucous and squamous cell carcinomas of the upper aerodigestive tract. DESIGN: Seventeen verrucous carcinomas and 10 squamous cell carcinomas of the upper aerodigestive tract were examined for the immunohistochemical expression of ERK-1, ERK-2, and Raf-1 product. RESULTS: Raf-1 expression was intensely expressed in the most basal portions of the epithelium in verrucous carcinomas, but was minimally expressed in the suprabasalar areas. Anti-Raf-1 staining of the squamous cell carcinomas was diffuse and patchy throughout the tumor cells and was weak in intensity. There was no geographic preference of staining. The cytoplasmic expression of both ERK-1 and ERK-2 was predominantly negative in the most basal layers of the epithelium in the verrucous carcinomas, but was positive in the suprabasalar region of the epithelium. Immunohistochemical expression of ERK-1 and ERK-2 in the squamous carcinomas was diffuse throughout the tumor. CONCLUSION: There is strong correlation of the geographic expression of these mediators of ras signal transduction in verrucous and squamous carcinomas, but the cause of these differences remains unclear at present. The expression of these mediator proteins may have potential for diagnosis, as well as in understanding the biologic behavior of these lesions.
UI - 21437016
AU - Renkonen J; Rabina J; Mattila P; Grenman R; Renkonen R
TI - Core 2 beta1,6-N-acetylglucosaminyltransferases and alpha1,3-fucosyltransferases regulate the synthesis of O-glycans on selectin ligands on oral cavity carcinoma cells.
SO - APMIS 2001 Jul-Aug;109(7-8):500-6
AD - Department of Bacteriology and Immunology, Haartman Institute, Haartmaninkatu 3, FIN-0014 University of Helsinki, Helsinki, Finland. Jutta.Renkonen@Helsinki.Fi
Selectin-dependent cell binding has importance in the extravasation of blood-circulating tumor cells and in the generation of metastases. Cell surface glycoproteins decorated with sialylated, fucosylated epitopes, such as sialyl Lewis(x) (sLe(x)), are ligands for selectins. Not only terminal sLe(x) moieties but also proximal core structures contribute to the formation of binding epitopes for selectins. Core 2 beta1,6-N-acetylglucosaminyltransferases (C2GnT) and alpha1,3-fucosyltransferases (alpha1,3-FucT) have been suggested to be the rate-limiting enzymes in the synthesis of selectin ligands. We analyzed oral cavity epithelial carcinoma cell lines and showed their expression of RNA transcripts for C2GnT and alpha1,3-FucT, identified alpha1,3-FucT enzyme activities, and analyzed the cell surface sLe(x) expression levels. Neither the pattern of expressed enzymes nor the alpha1,3-FucT activity directly predicted the binding capacity of E-selectin. However, only the sLe(x)-expressing cell lines were capable of binding to E-selectin, but not to P-selectin, thus putatively promoting the selectin-mediated metastasis. These findings suggest that C2GnT in combination with alpha1,3-Fuc-T contribute to the selectin-mediated metastasis in oral cavity carcinomas.
UI - 21453631
AU - Ducic Y; Herford AS
TI - The use of palatal island flaps as an adjunct to microvascular free tissue transfer for reconstruction of complex oromandibular defects.
SO - Laryngoscope 2001 Sep;111(9):1666-9
AD - Department of Otolaryngology, the University of Texas Southwestern Medical Center, Dallas, Texas, USA. Yducic@aol.com
OBJECTIVE: To determine the efficacy of using palatal island flaps in combination with free tissue transfer for reconstruction of large, complex oral cavity defects. STUDY DESIGN: Prospective evaluation of patients with large, combined defects of the oral cavity reconstructed with palatal flaps in conjunction with microvascular free tissue transfer. METHODS: Elevation of a palatal flap was performed after completion of tumor resection. The flap was rotated and secured into place. A free flap was then harvested and inset to reconstruct the remaining oromandibular defect. Free flaps included the rectus abdominis (6), fibula (16), and radial forearm (6). RESULTS: Large complex oral cavity defects were repaired with a palatal island flap in conjunction with microvascular free tissue transfer in 28 consecutive patients. There were no complications associated with this flap. CONCLUSION: Maximal functional rehabilitation of large, complex oral defects requires independent reconstruction of the various regions of the oral cavity rather than single flap reconstruction. When used as an adjunct to free tissue transfer, the palatal island flap offers a reliable method for reconstructing large combination defects.
UI - 21450508
AU - Zuccoli G; Ferrozzi F; Tognini G; Troiso A
TI - Enlarging tongue masses in neurofibromatosis type 1: MR findings of two cases.
SO - Clin Imaging 2001 Jul-Aug;25(4):268-71
AD - Radiology Department, Arcispedale Santa Maria Nuova, Viale Risorgimento 80, 42100, Reggio Emilia, Italy. email@example.com
Plexiform neurofibromas usually occur in the neck, pelvis, and extremities. Jaws and oral cavity plexiform neurofibromas have also been described. Magnetic resonance (MR) patterns for neurofibromas are typical. They include low-to-intermediate signal intensity on T1-weighted images, enhancement of the solid component of the tumor after contrast medium administration, heterogeneity on T2-weighted images, and in some cases, multiple target signs due to a collagen central area. We report MR findings of two neurofibromatosis type 1 (NF1) patients with enlarging tongue plexiform neurofibromas.
UI - 21463432
AU - Wardman P; Folkes LK; Bentzen SM; Stratford MR; Hoskin PJ; Phillips H;
TI - Jackson S Influence of plasma glutathione levels on radiation mucositis.
SO - Int J Radiat Oncol Biol Phys 2001 Oct 1;51(2):460-4
AD - Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex, UK. firstname.lastname@example.org
PURPOSE: To test the hypothesis that there is a link between plasma glutathione (GSH) or other antioxidants (uric acid, ascorbate) and the severity of radiation mucositis following radiation treatment of tumors of the head and neck. PATIENTS AND METHODS: Patients with carcinomas of the head-and-neck region were treated with the continuous hyperfractionated accelerated radiotherapy (CHART) regimen (54 Gy in 36 fractions over 12 days). Samples of blood plasma were analyzed for GSH, cysteine, urate, and ascorbate by high-pressure liquid chromatography. Patients were graded for dysphagia and requirement for analgesics. The areas under the curves of scores over 2-6 weeks following treatment were computed, and Spearman's rank-correlation coefficient was used to test for an association between plasma GSH levels (or those of other antioxidants) and mucositis. RESULTS: The pretreatment plasma GSH level in 18 patients scored in the study was 1.0 +/- 0.7 M. Analysis of these and the dysphagia scores produced a correlation coefficient of 0.22 (confidence interval -0.28, 0.61; p = 0.39). No correlation was seen between mucositis severity and other measures of plasma antioxidants: cysteine (7.6 +/- 1.7 M), cysteine + GSH (8.6 +/- 1.9 M), uric acid (317 +/- 86 M), ascorbate (29 +/- 20 M), or whole-blood GSH concentrations (1,010 +/- 239 M). CONCLUSION: The measurements of approximately micromolar levels of plasma GSH, or about 10 M cysteine + GSH (almost all of the total nonprotein thiols), are consistent with most other published data for either healthy adults or cancer patients; however, the values reported in an earlier study, suggesting a link between GSH and mucositis, are much higher. The hypothesis of a possible link between radiation mucositis and plasma-free (nonprotein) thiols was not supported.
UI - 21464090
AU - Yamamoto T; Satake H; Ueta E; Kimura T; Doi S; Osaki T
TI - [Influence of peplomycin on pulmonary function (PaO2, %DLco) in patients with oral carcinoma]
SO - Gan To Kagaku Ryoho 2001 Sep;28(9):1251-6
AD - Dept. of Oral Surgery, Kochi Medical School.
The pathogenesis of pulmonary fibrosis (PF) induced by bleomycin and its derivative, peplomycin (PEP), is insufficiently understood. To prevent PF and to administer PEP safely, we examined the influence of PEP on pulmonary function in 135 patients who underwent concomitant chemo (PEP + 5-FU)-radio (60Co) therapy and pulmonary function tests. In the inductive therapy, 5 mg of PEP was intramuscularly injected three times a week and a total of 41.6 +/- 14.3 mg was administered. Of the patients, 98 received oral azelastine hydrochloride (AZH, 4 mg/day) during the inductive therapy with the aim of prophylaxis of PF. The oxygen partial pressure in arterial blood (PaO2) only slightly decreased from 84.2 +/- 12.1 mmHg before treatment to 82.8 +/- 12.5 mmHg after treatment, while, carbon oxide diffusion (%DLco) decreased after treatment in most patients (p < 0.001, by paired t test) with mean values before treatment of 106.3 +/- 24.5% and after treatment 99.5 +/- 24.9%. The decrease of %DLco was associated with the dose of PEP until about 40 mg but further decreases of %DLco were not prominent. In the patients who underwent oral AZH, the decrease of %DLco weaker than that in patients without AZH: the decrease rates of %DLco in the former and latter were 4.3 +/- 9.4% and 14.1 +/- 15.9%, respectively. From the chest X-ray examination, mild PF was suspected in three patients but no advancement of PF or clinical symptoms were observed. From these results, it was concluded first that %DLco is more useful than PaO2 as the predisposing risk factor for PF, second that the decrease of %DLco depends on the dose of PEP until about 40 mg, third that AZH is expected to inhibit PEP-induced PF, and fourth that a small dose (20-40 mg) of PEP can be administered without inducing PF if care is exercised as to the patient's age, general condition and the value of %DLco in the use of PEP.
UI - 21464094
AU - Iwabuchi H; Takamori K; Honma H; Asanami S; Tanaka Y
TI - [A case of mandibular gingival cancer T4N0M0 which markedly responded to a combined therapy of nedaplatin with 5-fluorouracil]
SO - Gan To Kagaku Ryoho 2001 Sep;28(9):1273-6
AD - Dept. of Dentistry and Oral Surgery, School of Medicine, Keio University.
We recently experienced a case of mandibular gingival cancer T4N0M0 which markedly responded to a combination therapy of nedaplatin (254-S) with 5-fluorouracil (5-FU). The patient was a 68-year-old male who visited our department with the main complaint of ulceration in the left mandibular gingiva. Biopsy revealed a moderately differentiated squamous cell carcinoma which extended to the mandible, mandibular gingiva, buccal mucosa, half tongue and oral floor on the left side of the face. As a neoadjuvant chemotherapy (NAC), 254-S at a dose of 100 mg/m2 was intravenously administered on day 1, while 5-FU at a dose of 700 mg/m2/day was intravenously administered from day 1 to 5 in succession. Hydration (2,000 ml/day) was performed from day 1 to 3. Adverse reactions observed included thrombocytopenia, anorexia, nausea, vomiting, stomatitis and SIADH, but no sign of renal dysfunction was observed. The clinical outcome was evaluated as CR. Surgery was performed later. Pathological examination of the extracted tissues showed tumor cells in the tongue only, indicating an excellent effect of this combination therapy of 254-S and 5-FU.
UI - 99455416
AU - Devauchelle B
TI - [Squamous cell carcinoma of the tongue. Epidemiology, diagnosis, complications and long-term treatment]
SO - Rev Prat 1999 Sep 1;49(13 Suppl):1451-8
AD - Service de chirurgie maxillo-faciale, CHU d'Amiens.
UI - 21013949
AU - Pozharitskaia MM; Tabolinovskaia TD; Krasnova VV
TI - [Prevention of cancer of the buccal mucosa]
SO - Stomatologiia (Mosk) 2000;79(6):41-3
Cancer of the buccal mucosa ranks fourth in the structure of cancers. Pretumor processes of the buccal mucosa are Bouin's disease, leukoplakia verrucosa, papillomatosis, erosive ulcerative and hyperkeratotic lupus erythematosus and lichen planus, and postradiation stomatitis. Two clinical cases of cancer of the tongue in young men aged 27 years are described. Preventive measures are treatment of pretumor processes in the buccal mucosa, absolute refusal from caustics and from dentures made of different materials, regular check-ups of patients, consultations at specialized oncological institutions with cytological and morphological studies, thorough sanitation of the oral cavity including therapy, surgery, and orthodontic treatment.
UI - 21381746
AU - Hassan KA; El-Naggar AK; Soria JC; Liu D; Hong WK; Mao L
TI - Clinical significance of cyclin B1 protein expression in squamous cell carcinoma of the tongue.
SO - Clin Cancer Res 2001 Aug;7(8):2458-62
AD - Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
PURPOSE: Cyclin B1 plays an important role in control of the G(2)-M transition of the cell cycle. We have shown recently that overexpression of cyclin B1 is associated with poor outcome in patients with early stage squamous cell carcinoma (SCC) of the lung. EXPERIMENTAL DESIGN: To determine the role of cyclin B1 in SCC of the tongue, we analyzed tumor specimens from 41 patients with stage II-IV SCC of the tongue who underwent curative surgery using immunohistochemistry. RESULTS: The median follow-up of all patients was 83 months. Overexpression of cyclin B1 was observed in 15 (37%) of the 41 tumors, a similar frequency to that found in SCC of the lung. Patients whose tumors showed overexpression of cyclin B1 had a poor event-free survival compared with those lacking this feature (P = 0.04 by Log-rank test). Multivariate analysis of traditional clinical/pathological factors showed that cyclin B1 overexpression was an independent prognostic indicator. CONCLUSIONS: Our study indicates that cyclin B1 is overexpressed in a subset of SCC of the tongue and is associated with a more aggressive biological behavior of the disease.
UI - 21433337
AU - Pfau P; Chak A
TI - Detection of preinvasive cancer cells: early-warning changes in precancerous epithelial cells can now be spotted in situ and Endoscopic detection of dysplasia in patients with Barrett's esophagus using light-scattered spectroscopy.
SO - Gastrointest Endosc 2001 Sep;54(3):414-6
UI - 21419021
AU - Tomikawa M; Higuchi Y; Saku M; Takeshita M; Yoshida K; Sugimachi K
TI - Carcinoma of the colon metastatic to the lower gingiva.
SO - Dig Surg 2001;18(4):333-5
AD - Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. email@example.com
A case of carcinoma of the colon that metastasized to the lower gingiva is described. The patient who had carcinoma of the colon developed a proliferating lesion at the site of a recent tooth extraction. A few days later, the primary site of the malignancy appeared. The clinical features in such cases were reviewed in studies by others, most of which were of oral and dental surgery. Thus, because of our case, gastroenterologists should consider the possibility of gingival metastasis from malignant disease such as colorectal cancer. Copyright 2001 S. Karger AG, Basel
UI - 21449110
AU - Humphris GM; Ireland RS; Field EA
TI - Randomised trial of the psychological effect of information about oral cancer in primary care settings.
SO - Oral Oncol 2001 Oct;37(7):548-52
AD - Department of Clinical Psychology, School of Health Sciences, Whelan Building, The University of Liverpool, Liverpool L69 3GB, UK. firstname.lastname@example.org
AIM: To determine the immediate influence of a validated patient information leaflet (PIL) on patient anxiety and intention to have a screen for oral cancer in primary care attenders. PARTICIPANTS: Patients (n=800) attending their primary health care provider. SETTING: Fourteen general practices (eight dental and six medical) in the northwest of England. DESIGN: Randomised controlled trial with two arms: leaflets provided in information group, leaflet was absent in control group. MEASURES: Single item ratings of (1) intention to have an oral cancer screen, and (2) anxiety towards a screen, (3) perceived risk of oral cancer. Knowledge of oral cancer, self-reported dental service attendance history and demographic variables were also collected. RESULTS: Patients who had read