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Abramson Cancer CenterNCI CANCERLIT® Search: Wilms' Tumor, Hereditary - January 2002
National Cancer Institute®
Last Modified: January 1, 2002
Table of Contents
1
UI - 11444705
AU - Brunelli JP; Robison BD; Thorgaard GH
TI -
Ancient and recent duplications of the rainbow trout Wilms' tumor gene.
SO - Genome 2001 Jun;44(3):455-62
AD - School of Biological Sciences, Washington State University, Pullman
99164-4236, USA.
The Wilms' tumor suppressor (WT1) gene plays an important role in the
development and functioning of the genitourinary system, and mutations
in this gene are associated with nephroblastoma formation in humans.
Rainbow trout (Oncorhynchus mykiss) is one of the rare animal models
that readily form nephroblastomas, yet trout express three distinct WT1
genes, one of which is duplicated and inherited tetrasomically. Sequence
analyses suggest an ancient gene duplication in the common ancestor of
bony fishes resulted in the formation of two WT1 gene families, that
conserve the splicing variations of tetrapod WT1, and a second
duplication event occurred in the trout lineage. The WT1 genes of one
family map to linkage groups 6 and 27 in the trout genome map. Reverse
transcribed polymerase chain reaction (RT-PCR) expression analysis
demonstrated little difference in W
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.
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