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NCI CANCERLIT® Search: Salivary Gland Cancer - April 2002
National Cancer Institute®
Last Modified: April 1, 2002
Table of Contents
1
UI - 11776923
AU - Guo J; Zhang Y; Zheng W
TI -
[The application of color Doppler ultrasound technique in diagnosing the
lumps of salivary gland]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 1999 May;34(3):142-4
AD - School of Stomatology, Fourth Military Medical University, Xi'an 710023.
OBJECTIVE: To evaluate the value of color doppler ultrasound technique
in diagnosing the lumps of salivary gland. METHODS: 233 cases of
salivary gland lumps were examined with color doppler high frequency
ultrusound technique. Among them were, 189 cases benign and the others
malignant. RESULTS: Color doppler ultrasound technique could not only
show the morphology, structure, sizc, location and adjoining
relationship, but also indicate the pathological classification
according to the blood supply. The total coincident rate of this
ultrasound diagnosis to the pathological one was 89.3%. CONCLUSION:
Color doppler ultrasound technique is a simple and harmless diagnosing
method and could preoperatively give a reliable information to the
decision of surgical plan.
2
UI - 11905347
AU - Ord RA
TI -
Surgical management of parotid disease.
SO - Atlas Oral Maxillofac Surg Clin North Am 1998 Mar;6(1):1-28
AD - Division of Oral and Maxillofacial Surgery, University of Maryland
Medical Systems, Oncology Program, University of Maryland Cancer Center,
Baltimore, Maryland, USA.
3
UI - 11905351
AU - Carlson ER; Schimmele SR
TI -
The management of minor salivary gland tumors of the oral cavity.
SO - Atlas Oral Maxillofac Surg Clin North Am 1998 Mar;6(1):75-98
AD - Division of Oral and Maxillofacial Surgery, Center for Maxillofacial
Tumor and Reconstructive Surgery, University of Miami School of
Medicine, Coral Gables, Florida, USA.
4
UI - 11917592
AU - Leon ME; Deschler D; Wu SS; Galindo LM
TI -
Fine needle aspiration diagnosis of lipoblastoma of the parotid region.
A case report.
SO - Acta Cytol 2002 Mar-Apr;46(2):395-404
AD - Departments of Pathology and Laboratory Medicine and of Ear, Nose and
Throat Surgery, Medical College of Pennsylvania-Hahnemann University,
Broad and Vine St., Mail Stop 435, Philadelphia, Pennsylvania 19102,
USA.
BACKGROUND: Lipoblastomas are rare tumors of embryonal fat that occur in
infants and children. They are usually located in the extremities and
trunk. Two cases in the parotid region have been described. A diagnosis
on fine needle aspiration (FNA) specimens has been reported in six
cases. CASE: Lipoblastoma of the parotid region occurred in a 6-year-old
boy and was diagnosed by FNA. Cytology showed rare lipoblasts and
hibernomalike cells in a myxoid background with spindle and stellate
mesenchymal cells, mature adipose cells and plexiform capillaries. A
7.0-cm, well-circumscribed mass with lobulated adipose tissue and
delicate fibrous bands was resected. Microscopically, it showed a
lobulated myxoid stroma, many capillaries, mesenchymal cells, lipoblasts
and mature adipose cells. CONCLUSION: Lipoblastoma has to be
differentiated from myxoid and lipomatous soft tissue tumors, especially
from myxoid liposarcoma, a malignancy that classically affects older
individuals and shows pleomorphism, atypical lipoblasts and
chromosome-12 translocation. A lipoblastoma diagnosis must be
established only after careful consideration of all available clinical,
radiologic, cytogenetic and morphologic data.
5
UI - 11917601
AU - Sironi M; Claren R; Spinelli M; Lo Re V; Fibbi L
TI -
Could Warthin's tumor become metaplastic after fine needle aspiration?
SO - Acta Cytol 2002 Mar-Apr;46(2):436-8
6
UI - 11870967
AU - Manoharan M; Othman NH; Samsudin AR
TI -
Hyalinizing clear cell carcinoma of minor salivary gland: case report.
SO - Braz Dent J 2002;13(1):66-9
AD - Department of Pathology, Hospital Universiti Sains Malaysia (HUSM),
Kubang Kerian, Kelantan, Malaysia. madhavan@kb.usm.my
Hyalinizing clear cell carcinoma is a low-grade neoplasm of the minor
salivary gland composed exclusively of epithelial cells and not
myoepithelial cells. It predominantly affects the oral cavity of adult
females. It is microscopically characterized by hyalinizing stroma and
clear cells, which are typically positive for cytokeratin markers and
negative for S 100 and smooth muscle actin (SMA). Cystic degeneration
can also be present. Pathologists should be aware of this new entity so
as not to misdiagnose otherwise. To our knowledge, this is the first
case report of its kind from Malaysia.
7
UI - 11905056
AU - Beppu T; Kamata SE; Kawabata K; Nigauri T; Hoki K; Mitani H; Yoshimoto S
TI -
[Strategy of neck dissection in parotid cancer]
SO - Nippon Jibiinkoka Gakkai Kaiho 2002 Feb;105(2):178-87
AD - Division of Head and Neck, Cancer Institute Hospital, Tokyo.
We conducted definitive surgery on 45 patients with untreated primary
parotid cancer from 1975 to 1995, and evaluated methods of neck
dissection and results of treatment. All 14 with clinical neck lymph
node metastasis underwent ipsilateral radical neck dissection and only 1
developed neck lymph node recurrence at the peripheral dissected site.
Of 31 patients without clinical neck lymph node metastasis, 27 of 19 of
36 with high-grade malignancy and 12 of 24 with T3 or T4 did not undergo
prophylactic neck dissection and developed latent neck lymph node
metastasis in 2 cases (7.4%). Whereas in most cases we achieved good
control of the primary site but neck lymph node recurrences occurred,
recurrent sites were observed all around the ipsilateral neck and
prognosis were very poor if neck dissection was conducted as secondary
treatment. Although histopathological diagnosis was considered feasible
for predicting occult neck lymph node metastasis, correct diagnostic
with fine needle aspiration cytology revealed only 21.8%. Pathological
positive lymph nodes in 15 patients who underwent neck dissection were
detected all over (level I to V) the ipsilateral neck and the recurrent
positive rate at level II was 100%. Based on the above results, we
conclude that (1) in cases with neck lymph node metastasis in
preoperative evaluation, ipsilateral radical neck dissection is
mandated, and (2) in cases without neck lymph node metastasis,
prophylactic neck dissection is not usually needed. When pathological
results of frozen section from intraoperative jugulodigastric nodal
sampling are positive, ipsilateral radical neck dissection is mandated.
8
UI - 11827585
AU - Mahlstedt K; Ussmuller J; Donath K
TI -
Malignant sialogenic tumours of the larynx.
SO - J Laryngol Otol 2002 Feb;116(2):119-22
AD - Department of Audiology and Phoniatry, University Hospital Benjamin
Franklin, Free University of Berlin, Germany. mahl@zedat.fu.berlin.de
Laryngeal manifestations of malignant sialogenic neoplasias are rare.
This paper documents the clinical features, treatment, biological
behaviour and prognosis of 15 cases of malignant sialogenic tumours of
the larynx that were reviewed in a retrospective clinical and
histopathological study. The 15 cases of malignant sialogenic tumours of
the larynx were diagnosed at the University Hospital, Eppendorf, over a
period of 33 years (1965-1998). Forty per cent were adenoid cystic
carcinomas, 33 per cent mucoepidermoid carcinomas and 27 per cent were
poorly differentiated adenocarcinomas. Local tumour resection, if
necessary in combination with bilateral neck dissection and
post-operative radiotherapy, was associated with a five-year survival
rate in 80 per cent of the mucoepidermoid carcinoma cases. Adenoid
cystic carcinoma was associated with a less favourable five-year
survival rate of 33 per cent. Low-differentiated adenocarcinomas were
associated with the least favourable prognosis with a five-year survival
rate (25 per cent). The prognosis for these tumours is thus poorer than
for squamous cell carcinomas with the same localization and TNM status.
9
UI - 11844056
AU - Shigeishi H; Hayashi K; Takata T; Kuniyasu H; Ishikawa T; Yasui W
TI -
Pleomorphic adenoma of the parotid gland with extensive bone formation.
SO - Pathol Int 2001 Nov;51(11):883-6
AD - First Department of Pathology, Hiroshima University Faculty of Medicine,
Japan.
We report an unusual case of pleomorphic adenoma with extensive bone
formation, occurring in the parotid gland of a 58-year-old Japanese man.
The tumor was a well-circumscribed mass that measured 20 x 20 x 15 mm
and contained extensive bone formation. Histologically, most of the
tumor was composed of bone and chondroid tissues. The bone formation
with a marrow-like structure occupied half the volume of the tumor. The
chondroid tissues merged continuously into bone tissues. The bone tissue
seemed to be formed within areas of chondral tissue by a process of
enchondral ossification. Except for the unusual amount of large bone
formation, the tumor showed histology of pleomorphic adenoma,
particularly at the periphery of the tumor. These histological findings
suggest the possibility of extensive enchondral ossification in
pleomorphic adenoma.
10
UI - 11891949
AU - Wong DS
TI -
Frozen section during parotid surgery revisited: efficacy of its
applications and changing trend of indications.
SO - Head Neck 2002 Feb;24(2):191-7
AD - Division of Head & Neck/Plastic & Reconstructive Surgery, Department of
Surgery, Queen Mary Hospital, University of Hong Kong Medical Center,
Pokfulam, Hong Kong, China. sywong@ha.org.hk
BACKGROUND: Efficacy of frozen sections was assessed in terms of its
various applications. The changing role of frozen sections in parotid
surgery was examined. METHOD: Records of parotid operations over a
15-year period in a University Department of Head & Neck Surgery were
reviewed. RESULTS: Of 241 operations, frozen sections were performed on
32. Applications of frozen sections included diagnosis, margin
clearance, and checking suspicious lymph nodes and nerve invasion. The
false-positive rate for malignancy was 12.5%. Margins may still be
involved despite correct tissue diagnosis from sampling error. No
inappropriate surgery resulted from the information obtained. With the
advent of fine-needle aspiration, frozen sections were less often called
for and a shift from a diagnostic role to margin checking was seen.
Frozen sections picked up all unsuspected malignant tumors. CONCLUSION:
Frozen sections are helpful when interpreted cautiously, but clinical
assessment and fine-needle aspiration are also important components in
the workup.
11
UI - 11891964
AU - Curry JL; Petruzzelli GJ; McClatchey KD; Lingen MW
TI -
Synchronous benign and malignant salivary gland tumors in ipsilateral
glands: a report of two cases and a review of literature.
SO - Head Neck 2002 Mar;24(3):301-6
AD - Department of Pathology, Loyola University Medical Center, Loyola
University Medical Center, 2160 S First Avenue, Maywood, Illinois 60153,
USA. jcurry3@luc.edu
BACKGROUND: Ipsilateral salivary gland tumors of different histologic
types are rare and make up less than 0.3% of all salivary gland
neoplasms. Only nine cases of synchronous benign and malignant
ipsilateral parotid gland tumors have been described in the literature.
METHODS: Two additional cases of synchronous benign and malignant
neoplasms in the parotid gland are reported and discussed with a review
of literature. RESULTS: Our first case describes a pleomorphic adenoma
and a salivary duct carcinoma, an entity not previously reported in the
literature. The second case documents the most common benign and
malignant ipsilateral parotid gland neoplasm reported in this case
series, a Warthin's tumor and a mucoepidermoid carcinoma. CONCLUSIONS:
Synchronous salivary gland tumors exhibiting both benign and malignant
components are uncommonly observed, with only nine cases published to
date. We describe two additional cases of a synchronous benign and
malignant ipsilateral parotid gland tumor. Copyright 2002 Wiley
Periodicals, Inc.
12
UI - 11895487
AU - Hirokawa M; Sugihara K; Sai T; Monobe Y; Kudo H; Sano N; Sano T
TI -
Secretory carcinoma of the breast: a tumour analogous to salivary gland
acinic cell carcinoma?
SO - Histopathology 2002 Mar;40(3):223-9
AD - Department of Pathology, University of Tokushima School of Medicine,
Tokushima, Japan. hirokawa@basic.med.tokushima-u.ac.jp
AIMS: Acinic cell-like breast carcinoma is a newly recognized entity,
and few acinic cell-like breast carcinoma cases have been reported. All
reported acinic cell-like breast carcinomas were counterparts of the
solid type of acinic cell carcinoma of the salivary gland. We report
here three cases of secretory breast carcinoma with acinic cell
differentiation, and discuss the similarity between secretory breast
carcinoma and acinic cell carcinoma of the salivary gland. METHODS AND
RESULTS: The cases were histologically identical to acinic cell
carcinoma of the salivary gland: papillary-cystic type in case 1, a
mixture of papillary-cystic, microcystic and follicular type in case 2,
and microfollicular type in case 3. Immunohistochemically, the tumour
cells were positive for salivary-type amylase, lysozyme, S100 protein
and alpha 1-antitrypsin, and negative or less reactive for gross cystic
disease fluid protein-15 and oestrogen receptor. All three cases did not
reveal metastasis or recurrence. CONCLUSIONS: These cases were typical
of secretory breast carcinoma, and were clinically, histologically and
immunohistochemically analogous to acinic cell carcinoma of the salivary
gland. We emphasize that secretory breast carcinoma and acinic cell
carcinoma of the salivary gland may be identical lesions.
13
UI - 11821774
AU - Amin KS; McGuff HS; Cashman SW; Newman R
TI -
Recurrent epithelial-myoepithelial carcinoma of the parotid with direct
intracranial extension.
SO - Otolaryngol Head Neck Surg 2002 Jan;126(1):83-4
AD - Department of Pathology, Division of Oral, Head, and Neck Pathology,
University of Texas Health Science Center at San Antonio, 78229-7750,
USA. amin@pathology.uthsca.edu
14
UI - 11583402
AU - Jaehne M; Ussmuller J; Jakel KT; Zschaber R
TI -
The clinical presentation of non-hodgkin lymphomas of the major salivary
glands.
SO - Acta Otolaryngol 2001 Jul;121(5):647-51
AD - Department of ENT, University of Hamburg, Germany.
jaehne@uke.uni-hamburg.de
The aim of this study was to examine the clinical presentation of
patients with malignant lymphoma of the major salivary glands. In a
retrospective study, 26 patients with a non-Hodgkin lymphoma (NHL) of
the major salivary glands were examined. The results showed a distinct
preference for the female gender. Two groups with clinical differences
were observed depending on lymphoma manifestation as either
extranodal-parenchymal (extranodal) or with intra- or periglandular
(nodal) lymph node disease. Differences between these two groups existed
with regard to the length of clinical history, recurrent vs continuously
progressing symptoms and presentation on ultrasound examination
(multiple masses compared to solitary masses). Patients with an
extranodal lymphoma always showed disease limited to the affected gland,
whereas those patients with a nodal lymphoma presented with stage II or
higher (Ann Arbor Classification). In these patients, local recurrence
was also five times higher (5/13; 38.4%) than in patients with an
extranodal lymphoma (1/13; 7.7%). In 1 patient (7.7%) with extranodal
lymphoma, dissemination was observed, compared to 6/13 patients (46.2%)
in the group with nodal disease. Seven out of 13 patients (53.8%) with
nodal disease died due to lymphoma spread and 1/13 (7.7%) of the
patients with extranodal disease. There seem to be distinct clinical
differences in the course of patients with NHL of the major salivary
glands, depending on extranodal or nodal disease presentation. The
histopathological diagnosis, with special recognition of the particular
lymphoma pathogenesis, constitutes an important prognostic factor in
these patients.
15
UI - 11772498
AU - Nakagawa T; Hattori K; Iwata N; Tsujimura T
TI -
Papillary cystadenocarcinoma arising from minor salivary glands in the
anterior portion of the tongue: a case report.
SO - Auris Nasus Larynx 2002 Jan;29(1):87-90
AD - Department of Otolaryngology, Sumitomo Hospital, 5-3-20 Nakanoshima,
Kita-ku, Osaka 530-0005, Japan. nakataka@msc.hosp.med.osaka-u.ac.jp
Papillary cystadenocarcinoma is a rare malignant neoplasm of the
salivary gland. We report a case of papillary cystadenocarcinoma arising
from the minor salivary gland in the anterior portion of the tongue of a
72-year-old male patient with a history of adenocarcinoma of the colon
and prostate. Further, we discussed histopathological and clinical
features of this lesion, and reviewed the literature.
16
UI - 11772499
AU - Yoshizaki T; Himi Y; Minato H; Ogawa I; Nikai H; Furukawa M
TI -
Malignant myoepithelioma arising from recurrent pleomorphic adenoma of
minor salivary gland.
SO - Auris Nasus Larynx 2002 Jan;29(1):91-4
AD - Department of Otolaryngology, School of Medicine, Kanazawa University,
13-1 Takaramachi, Kanazawa 920-0934, Japan. tomoy@med.kanazawa-u.ac.jp
Malignant myoepitheliomas of the salivary gland are very rare tumors
which may either arise de novo or develop in a pre-existing pleomorphic
adenoma. We report a case of malignant myoepithelioma of the minor
salivary gland that progressed from benign pleomorphic adenoma. The
original pleomorphic adenoma was resected in 1979 (the '79 tumor). The
first recurrent tumor was operated in 1995 (the '95 tumor). The '95
tumor was diagnosed as pleomorphic adenoma. Although the myoepithelial
tumor component was more prevalent in the '95 tumor, histological
features of the first recurrent tumor were similar to the '79 tumor. The
second recurrent tumor showed more aggressive clinical features (the '98
tumor). It also showed massive growth of myoepithelial tumor cells with
bone invasion, which led to the diagnosis of the '98 tumor as malignant
myoepithelioma. With adequate surgical margin, the patient has been free
from tumor recurrence for 20 months.
17
UI - 11772501
AU - Maini S; Osborne JE
TI -
Ischaemic necrosis and facial palsy in Warthin's tumour of the parotid
gland.
SO - Auris Nasus Larynx 2002 Jan;29(1):99-101
AD - Department of ENT, Royal Gloucestershire Hospital, Great Western Road,
Gloucester GLI 3NN, UK. sangeetamaini@hotmail.com
A 72-year-old patient with a Warthin's tumor of the right parotid gland
developed massive necrosis of the tumour associated with temporary
facial palsy with subsequent macroscopic tumour disappearance.
18
UI - 11942573
AU - Skalova A; Michal M; Simpson RH; Starek I; Pradna J; Pfaltz M
TI -
Sclerosing polycystic adenosis of parotid gland with dysplasia and
ductal carcinoma in situ. Report of three cases with immunohistochemical
and ultrastructural examination.
SO - Virchows Arch 2002 Jan;440(1):29-35
AD - Department of Pathology, Medical Faculty of Charles University, Plzen,
Czech Republic. skalova@fnplzen.cz
We describe three cases of sclerosing polycystic adenosis (SPA) of the
parotid gland, a salivary condition analogous to fibrocystic disease of
the breast. For the first time, immunoreactivity for oestrogen and
progesterone receptors was demonstrated, suggesting a possible
participation of hormone stimulation in its pathogenesis. In addition,
all our cases showed foci of dysplasia of the ductal epithelium, which
in one case was severe enough to amount to carcinoma in situ. This
feature that has not previously been reported in SPA.
19
UI - 11942580
AU - Stallmach I; Zenklusen P; Komminoth P; Schmid S; Perren A; Roos M;
TI -
Jianming Z; Heitz PU; Pfaltz M
Loss of heterozygosity at chromosome 6q23-25 correlates with clinical
and histologic parameters in salivary gland adenoid cystic carcinoma.
SO - Virchows Arch 2002 Jan;440(1):77-84
AD - Institute of Clinical Pathology, Department of Pathology, University of
Zurich, Switzerland.
The prognosis of salivary gland adenoid cystic carcinoma (ACC) depends
on the clinical stage, the location of the primary tumor, and the
histologic growth pattern. ACCs with a cribriform growth pattern have a
better prognosis than those with a solid growth pattern; however,
clear-cut grading criteria have not yet been established, and therefore
prognostic indicators on a molecular level are of special interest. In
order to analyze tumor tissue with different growth patterns, cribriform
and solid tumor areas of 25 patients were microdissected and separately
analyzed for loss of heterozygosity (LOH) at nine polymorphic
microsatellite markers located between 6q14 and 6q27. LOH was detected
in 19/25 (76%) patients and LOH rates were highest at markers D6S441,
D6S310, D6S311 and UTRN, which are located at 6q23-25. Combined analysis
of LOH at these four markers shows that in primary tumor subtype foci
with cribriform growth pattern LOH is associated with high TNM stages
(P<0.01), high T stages (P=0.01), positive lymph node status (P=0.03),
an unfavorable disease course (P=0.02), and the presence of >10% solid
growth pattern (P=0.05). In contrast, in primary tumor subtype foci with
solid growth pattern, no significant differences in LOH rates were found
in patients from prognostically and histologically favorable versus
unfavorable patient groups. The frequent occurrence of LOH at 6q23-25
and the correlation of LOH rates with prognostic parameters indicate
that a prognostically important tumor suppressor gene is located in this
chromosomal area.
20
UI - 9935220
AU - Sumida T; Hamakawa H; Sogawa K; Sugita A; Tanioka H; Ueda N
TI -
Telomerase components as a diagnostic tool in human oral lesions.
SO - Int J Cancer 1999 Jan 5;80(1):1-4
AD - Department of Oral Surgery, Ehime University School of Medicine,
Onsen-gun, Japan.
Telomerase activity is considered to be a diagnostic marker of
malignancy since most malignant cells express this activity and most
somatic cells do not. However, the detection of telomerase activity is
rather complicated and is affected by many factors. Recently, human
telomerase components were cloned and found to consist of 3 subunits. We
assessed which component of telomerase best correlates with malignancy
in order to study the possibilities for developing a new diagnostic
marker. Telomerase activity was measured by a telomeric repeat
amplification protocol (TRAP) assay, and the telomerase components hTR,
hTRT-mRNA and TP1-mRNA were detected by the reverse
transcriptase-polymerase chain reaction (RT-PCR). Twenty-five of 26 oral
malignant lesions, 9 of 22 benign lesions and none of 19 normal control
tissues exhibited distinct telomerase activity. hTR and TP1-mRNA
expression levels were detected in all malignant lesions and normal
control tissues and had no significant correlation with the telomerase
activity results. In contrast, hTRT-mRNA expression was closely
associated with telomerase activity. All lesions expressing hTRT were
telomerase positive. In addition, some samples of dysplastic lesions,
benign tumors, lichen planus and normal mucosa exhibiting poor
telomerase activity revealed weak expression of hTRT. Expression levels
of hTRT-mRNA positively correlated with clinical and pathological
findings. Detection of hTRT-mRNA by RT-PCR appeared to be more sensitive
for telomerase than measurement of telomerase activity by the TRAP
assay. Detection of hTRT-mRNA may provide information useful in the
diagnosis of oral malignancies.
21
UI - 11264006
AU - Azuma M; Yamashita T; Aota K; Tamatani T; Sato M
TI -
5-Fluorouracil suppression of NF-KappaB is mediated by the inhibition of
IKappab kinase activity in human salivary gland cancer cells.
SO - Biochem Biophys Res Commun 2001 Mar 23;282(1):292-6
AD - Second Department of Oral and Maxillofacial Surgery, Tokushima
University School of Dentistry, Tokushima, Japan.
azumasa@dent.tokushima-u.ac.jp
We have recently shown that 5-Fluorouracil (5-FU) suppresses the
transcription factor NF-kappaB in human salivary gland cancer cells
(cl-1) by mediating upregulation of IkappaB-alpha expression. However,
the precise mechanism involved in this action has not yet been
elucidated. IkappaB kinases (IKK-alpha and IKK-beta) are the key
components of the IKK complex that mediates activation of NF-kappaB in
response to external stimuli such as cytokines. In addition,
NF-kappaB-inducing kinase (NIK) and mitogen-activated protein kinase
kinase kinase 1 (MEKK-1), both of which are the upstream kinases for the
IKKs, interact with and activate the IKKs. Thus, we investigated the
molecular mechanisms involved in the suppression of NF-kappaB by 5-FU.
Although 5-FU did not affect the expression levels of IKKs, NIK, or
MEKK-1, IKK activity in cl-1 cells was suppressed at both 6 h and 12 h
after treatment with 2 microgram/ml 5-FU. Moreover, when cells were
treated with various concentrations of 5-FU for 12 h, the concentration
of 2 microgram/ml efficiently inhibited the IKK activity as compared to
1, 5, or 10 microgram/ml. The expression of Fas-associated death
domain-like interleukin 1-converting enzyme-inhibitory protein (FLIP),
which acts as an inhibitor of an initiator caspase (caspase-8), was
down-regulated by 5-FU treatment in cl-1 cells. Apoptosis, as evidenced
by cleavage of poly(ADP-ribose) polymerase through the action of an
executioner caspase (caspase-3), was also clearly observed. Thus, these
results suggest that 5-FU induction of apoptosis in cl-1 cells may be
mediated by suppression of NF-kappaB via inhibition of IKK activity.
Copyright 2001 Academic Press.
22
UI - 11890618
AU - Ethunandan M; Pratt CA; Macpherson DW
TI -
Changing frequency of parotid gland neoplasms--analysis of 560 tumours
treated in a district general hospital.
SO - Ann R Coll Surg Engl 2002 Jan;84(1):1-6
AD - Maxillofacial Unit, St Richard's Hospital, Chichester, West Sussex, UK.
An analysis of all parotidectomies performed for neoplastic lesions in
the maxillofacial unit at a district general hospital during a 26-year
period between 1974-1999 was undertaken. The details analysed were age,
sex, histology and temporal variations in the frequency of specific
tumour types during the study period. A total of 538 parotidectomies
performed on 529 patients in whom 560 tumours were present, formed the
basis of this study. Marked variations were present in the age and sex
distribution and relative frequency of specific tumour types in this
study, when compared to previous reports. There were also differences in
the age and sex distribution of pleomorphic adenoma and adenolymphoma (P
<0.0001) in this study. The relative frequency of benign tumours and
adenolymphoma increased, whereas that of pleomorphic adenoma decreased
during the study period. In addition, there was a statistically
significant decrease in the relative frequency of pleomorphic adenoma (P
<0.0001) and an increase in adenolymphoma (P <0.0001) when comparisons
were made with previous studies. This study from a defined population
may be more representative of the true proportion of specific tumours in
this population. The potential implications of the results on the
investigation and treatment of parotid neoplasms is highlighted.
23
UI - 11928107
AU - Ozcan C; Unal M; Talas D; Gorur K
TI -
Deep lobe parotid gland lipoma.
SO - J Oral Maxillofac Surg 2002 Apr;60(4):449-50
AD - Department of Otorhinolaryngology, School of Medicine, Mersin
University, Mersin, Turkey. cengizozcan@hotmail.com
24
UI - 11854064
AU - Webb AJ; Eveson JW
TI -
Parotid Warthin's tumour Bristol Royal Infirmary (1985-1995): a study of
histopathology in 33 cases.
SO - Oral Oncol 2002 Feb;38(2):163-71
AD - Department of Surgery, Bristol Royal Infirmary, Bristol BS2 8HW, UK.
This is a study of 33 (32 patients) confirmed Warthin's tumours
(adenolymphomas) treated surgically at Bristol Royal Infirmary
(1985--1995) focussing specifically upon 17 salient histopathological
features together with capsular measurement by micrometry. Twenty-four
out of 33 tumours had 'thin' capsules (< or = 200 microm), whereas 5/9
'thick' capsules were associated with gross tumour degeneration. The
degenerative features including cystic change, squamous metaplasia,
corpora amylacea like bodies, etc. were quantified. Tumours were
classified into subtypes (typical, stroma poor, etc). These variations
were not associated with age or sex. In 20/33 tumours a marginal sinus
suggested a lymph node origin. Fine needle aspiration cytology (FNA)
smears showing degeneration features are a diagnostic problem, but
histopathological features are reflected in such smears and their
recognition enhances diagnostic precision, enabling controlled surgical
enucleation, the ideal operation, to be performed in most cases. In this
study only 12 tumours were so treated; 11 others received parotidectomy.
The theories of histogenesis are reviewed and discussed.
25
UI - 11881728
AU - Sakurai K; Urade M; Noguchi K; Kishimoto H; Ishibashi M; Yasoshima H;
TI -
Yamamoto T; Kubota A
Increased expression of cyclooxygenase-2 in human salivary gland tumors.
SO - Pathol Int 2001 Oct;51(10):762-9
AD - Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine,
Nishinomiya, Japan. k-sakura@hyo-med.ac.jp
We examined the immunohistochemical localization of cyclooxygenase
(COX)-2 in human salivary gland tumors. Thirty salivary gland adenomas
(SGA), 40 salivary gland carcinomas (SGC) and 15 normal salivary glands
(NSG) were studied. NSG showed restricted COX-2 staining only in the
epithelial cells of salivary ducts. In contrast, COX-2 protein was
detected in 27 cases of SGA (90%), except for three myoepitheliomas, and
in all cases of SGC (100%) at various intensities and in various
fashions. Thirteen SGA (43%) and 36 SGC (90%) cases showed strong COX-2
staining predominantly in tumor cells containing ductal components, as
did serous and mucous acinic components of acinic cell carcinomas,
mucoepidermoid carcinomas and mucinous carcinomas. These findings may
suggest that COX-2 in salivary gland tumors is expressed in tumor cells
derived from pluripotential ductal epithelium that can histologically
develop into either serous or mucinous acinar cells.
26
UI - 11881733
AU - Watanabe M; Nakayama T; Koduka Y; Katoh H; Hirokawa Y; Inoue R; Imai H;
TI -
Nakano H; Shiraishi T
Mycobacterium tuberculosis infection within Warthin's tumor: report of
two cases.
SO - Pathol Int 2001 Oct;51(10):797-801
AD - Second Department of Pathology, Mie University Faculty of Medicine, Tsu,
Japan. mawata@doc.medic.mie-u.ac.jp
We report two patients with Warthin's tumor who were also infected with
Mycobacterium tuberculosis. Case 1 was a 75-year-old woman with
Warthin's tumor and multiple small epithelioid granulomas with caseous
necrosis involving the submandibular gland. This patient died of
tuberculous meningitis 4 months after biopsy. Case 2 was a 78-year-old
man with a 10-year history of a parotid mass which had enlarged rapidly
over 2 months. Surgical excision revealed Warthin's tumor and
epithelioid granulomas involving the left parotid gland. DNA extracted
from paraffin sections was amplified by nested polymerase chain reaction
(PCR) with primer sets for the mycobacterial 65-KDa antigen gene.
Restriction enzyme digestion of the PCR products could differentiate
Mycobacterium tuberculosis from other mycobacteria in both cases.
Although the histogenesis of lymphoid components of Warthin's tumor is
controversial, the frequent prevalence of inflammation or necrosis and
our present findings suggest these components have a similar behavior to
regional lymph nodes.
27
UI - 11930728
AU - Li F; Yu G; Peng S
TI -
[Antimetastatic effects of arginine-aspartate on salivary adenoid cystic
carcinoma in vitro]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 2001 Nov;36(6):464-6
AD - Department of Stomatology, International Peace Hospital, Shijiazhuang
050082, China.
OBJECTIVE: To test the effects of arginine-aspartate (RD) on metastasis
of salivary cystic carcinoma (SACC). METHODS: Highly metastatic SACC
cell line SACC-LM was used in the study. The effect of RD on tumor
cell-ECM adhesion was assayed by MTT technique. The effect of RD on
invasion and migration of SACC-LM were evaluated using modified boyden
chamber. RESULTS: RD inhibited tumor cell fibronectin adhesion at 5 mg/L
concentration, but no effects on tumor cell laminin and tumor cell type
IV collagen adhesion. RD inhibited the invasion at 1, 5, 25 mg/L, and
inhibited the migration only at 25 mg/L. CONCLUSIONS: The result shows
that the RD has an antimetastatic effect on SACC-LM cells in vitro.
28
UI - 11870635
AU - De Re V; De Vita S; Gasparotto D; Marzotto A; Carbone A; Ferraccioli G;
TI -
Boiocchi M
Salivary gland B cell lymphoproliferative disorders in Sjogren's
syndrome present a restricted use of antigen receptor gene segments
similar to those used by hepatitis C virus-associated non-Hodgkins's
lymphomas.
SO - Eur J Immunol 2002 Mar;32(3):903-10
AD - Division of Experimental Oncology 1, Centro di Riferimento Oncologico,
IRCS, Aviano, Italy.
Sjogren's syndrome (SS) represents a pathological model of the evolution
from polyclonal B lymphocyte activation to oligoclonal/monoclonal B cell
expansion, which may culminate in the development of a malignant
lymphoproliferative disease. The different phases of this process are
usually marked by the appearance of antigen-driven activated B cell
clones, which are commonly IgM-positive and with rheumatoid factor (RF)
activity. However, the agent(s) able to trigger B cell proliferation is
still unknown. A similar pathogenetic mechanism exist in mixed
cryoglobulinemia, another autoimmune disease that often evolves to
non-Hodgkin's lymphoma (NHL) and in which hepatitis C virus (HCV)
infection has been demonstrated to play an etiopathogenetic role. In the
present study, we cloned and sequenced the antigen receptor (IgR)
variable region genes of SS-associated monoclonal non-neoplastic
lymphoproliferations and compared them with those of our previous
reported HCV-associated NHL, to derive clues on the antigen(s) that
sustains SS. The results obtained showed remarkable homologies between
the antigen combinatory regions of the IgR expressed by both diseases.
These homologies concern: a) the specific combinations of heavy and
light variable region genes; b) the limited length of
complementarity-determining regions (CDR3); c) the homology with
antibodies with RF activity; d)the amino acid sequences of CDR3 in which
common somatic mutations are present that possibly determine the
antigen-binding specificity. In conclusion, although there are
significant differences between SS and HCV-associated
lymphoproliferative diseases, they share many molecular characteristics,
which suggest an immunological cross-reactivity or molecular mimicry
among the agents that underlie these disorders.
29
UI - 11668001
AU - Mohammed K; Harbourne G; Walsh M; Royston D
TI -
Solitary fibrous tumour of the parotid gland.
SO - J Laryngol Otol 2001 Oct;115(10):831-2
AD - Department of Pathology, Beaumont Hospital, Dublin 9, Ireland.
Solitary fibrous tumours are rare tumours originally described in the
pleura. More recently there have been reports of these tumours arising
at other sites including the parotid region. They are characterized
histologically by a variety of growth patterns that can be confused by
the unwary with other benign or malignant tumours particularly sarcomas.
We present a case occurring in the pre-auricular region which presented
diagnostic difficulties.
30
UI - 11945190
AU - Harney M; Walsh P; Conlon B; Hone S; Timon C
TI -
Parotid gland surgery: a retrospective review of 108 cases.
SO - J Laryngol Otol 2002 Apr;116(4):285-7
AD - Department of Otolaryngology, St. James's Hospital, Royal Victoria Eye
and Ear Hospital, Dublin, Ireland.
One hundred and eight parotidectomies performed by a single consultant
were reviewed. Eighty-five patients had primary parotid disease, 23
patients had extra-parotid primaries. Pleomorphic adenoma was the most
common histological diagnosis. In patients with primary parotid disease,
a post-operative temporary facial nerve palsy was noted in 15 patients,
with a further four developing a permanent palsy. Patients with
metastatic disease to the parotid had a poor prognosis.
31
UI - 11965641
AU - Thompson M; Cheng LH; Stewart J
TI -
Solitary fibrous tumour of the parotid gland.
SO - J Laryngol Otol 2002 Apr;116(4):319
32
UI - 11933184
AU - Ruzich JC; Ciesla MC; Clark JI
TI -
Response to paclitaxel and carboplatin in metastatic salivary gland
cancer: a case report.
SO - Head Neck 2002 Apr;24(4):406-10
AD - Hematology and Oncology, Cardinal Bernadin Cancer Center, Loyola
University Medical Center, 2160 South First Avenue, Maywood, Illinois,
USA.
BACKGROUND: Malignant tumors of the salivary gland are rare entities
that are treated primarily by surgical resection. For patients with
recurrent or unresectable disease, options include radiation therapy or
chemotherapy; however, responses are few and of short duration. Patients
with metastatic disease have been treated with chemotherapy, but, again,
response rates have been low and of short duration. METHODS: A
52-year-old man was seen with a mass on his tongue. A biopsy revealed
adenocarcinoma of a minor salivary gland. Ten months after surgical
resection, neck dissection, and radiation therapy, the patient was found
to have metastatic disease to the lung. Chemotherapy was initiated with
carboplatin and paclitaxel. RESULTS: The patient obtained a complete
response after six cycles of carboplatin and paclitaxel. CONCLUSIONS:
The use of carboplatin and paclitaxel in the setting of metastatic
salivary gland cancer is a viable option. Copyright 2002 Wiley
Periodicals, Inc.
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