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Abramson Cancer CenterNCI CANCERLIT® Search: Paranasal Sinus and Nasal Cavity Cancer - March 2002
National Cancer Institute®
Last Modified: March 1, 2002
Table of Contents
1
UI - 11681498
AU - Vassallo P; Tranfa F; Forte R; D'Aponte A; Strianese D; Bonavolonta G
TI -
Ophthalmic complications after surgery for nasal and sinus polyposis.
SO - Eur J Ophthalmol 2001 Jul-Sep;11(3):218-22
AD - Department of Ophthalmology, University of Naples Federico II, Napoli,
Italy.
PURPOSE: To describe ophthalmic complications after nasal and sinus
surgery. METHODS: Four cases with orbital complications were
retrospectively selected from among more than 2000 cases of orbital
pathologies. RESULTS: Motility disturbances due to extraocular muscle
injury occurred in two patients after intranasal ethmoidectomy and in
one patient after a Caldwell-Luc procedure. In the fourth case an
orbital apex syndrome was noted after intranasal ethmoidectomies.
CONCLUSIONS: Ophthalmic complications may occur after nasal and sinus
surgery, even using an endoscopic procedure. Successful handling of
these complications could be reached by on their early recognition and
treatment.
2
UI - 11771596
AU - Yoon JH; Chun YC; Park SY; Yook JI; Yang WI; Lee SJ; Kim J
TI -
Malignant lymphoma of the maxillary sinus manifesting as a persistent
toothache.
SO - J Endod 2001 Dec;27(12):800-2
AD - Department of Oral Pathology, Yonsei University, College of Dentistry,
Seoul, Korea.
Many teeth have been mistakenly extracted or endodontically treated
because of an incorrect diagnosis of orofacial pain, including
toothache. A case of persistent toothache originating from a malignant
lymphoma of the left maxillary sinus is presented. Root canal therapy
and extraction of the upper left quadrant teeth from the canine to the
second molar did not resolve the chief complaint. The patient was
referred to a neurologist and received a diagnosis of a malignant
lymphoma, a rare lesion of the maxillary sinus. This case stresses the
importance of considering malignant neoplasm of the maxillary sinus as a
potential etiologic factor in the differential diagnosis of orofacial
pain.
3
UI - 9065636
AU - Larsen K; Tos M
TI -
A long-term follow-up study of nasal polyp patients after simple
polypectomies.
SO - Eur Arch Otorhinolaryngol 1997;254 Suppl 1():S85-8
AD - ENT Clinic, Esbjerg, Denmark.
A long-term follow-up study was performed on randomly selected patients
after simple snare polypectomies. There were 243 patients, of whom 211
underwent endoscopic examination. There were 154 males and 57 females
and median age was 57.7 years. Median period of follow-up was 8 years
(range, 38-145 months). The median number of polypectomies was 1.6
(range, 1-15). Polyp eosinophilia was recorded in 97% of the cases. From
life-table analysis the 5-year rate for two or less polypectomies was
80% (95% confidence intervals, 75-86%). Symptoms and findings were
recorded at a median time of 56 months from the last polypectomy. At
this time 70% of the patients denied blocked nose or excessive
secretions. Seventeen per cent of the group claimed loss of sense of
smell, while 28% stated that it was poor. At follow-up, large polyps
were found in 3% of the patients, moderately sized ones in 30% and small
in 42%. No polyps were visible in 25%. Patients with asthma (26%) had
more polypectomies than those without (median, 2.4 versus 1.4). Patients
with a history of non-steroidal antiinflammatory drug intolerance (7%)
had the highest number of polypectomies. Previous troublesome sinusitis
and allergy seemed not to exert major influence on the number of
polypectomies needed. In the primary care of nasal polyp patients, the
majority only need minor or limited surgery or only medical treatment.
4
UI - 11793917
AU - Heermann R; Mack KF; Issing PR; Haupt C; Becker H; Lenarz T
TI -
[Skull base surgery with an opto-electronic navigation system]
SO - HNO 2001 Dec;49(12):1019-25
AD - HNO-Klinik, Medizinische Hochschule, Carl-Neuberg-Strasse 1, 30625
Hannover. hee@hno.mh-hannover.de
BACKGROUND AND OBJECTIVE: The exact localization of pathological anatomy
is the basis of a successful operation. Malformations, tumors, or
previous operations can make intraoperative orientation considerably
more difficult. Navigation systems can be useful tools in such cases.
METHODS: The OTS is an optoelectrical navigation system which was used
on 34 patients with disorders of the skull base region. Clinical
accuracy, practicability, and intraoperative usefulness of the system
were evaluated. RESULTS: In clinical use, an accuracy of approximately
1.5 mm could only be achieved with the use of head fixation and
bone-anchored reference markers. When using the VBH mouthpiece for
dynamic referencing with flexible head positioning, deviations of less
than 2 mm were observed. The preoperative preparation time was 15-25
min, depending on the operation schedule. CONCLUSIONS: The
intraoperative orientation system represents a significant aid for
orientation, particularly where anatomical alterations are present.
Further modifications to improve both accuracy and the integration of
the system into working practice are, however, essential.
5
UI - 11793922
AU - Weber R; Kratzsch B
TI -
[Endonasal transseptal frontal rhinotomy drainage. Indications and
surgical technique]
SO - HNO 2001 Dec;49(12):1047-58; quiz 1059-61
AD - Klinik fur HNO-Erkrankungen, Kopf- und Halschirurgie, Marienhospital
Stuttgart, Boheimstrasse 37, 70199 Stuttgart. rainerweber@vinzenz.de
6
UI - 11788143
AU - Bloom DC; Carvalho DS; Dory C; Brewster DF; Wickersham JK; Kearns DB
TI -
Imaging and surgical approach of nasal dermoids.
SO - Int J Pediatr Otorhinolaryngol 2002 Feb 1;62(2):111-22
AD - Division of Pediatric Otolaryngology, Children's Hospital and Health
Center, Naval Medical Center San Diego, 34800 Bob Wilson Drive, Suite
200, San Diego, CA 92134-2200, USA. dcbloom@hotmail.com
OBJECTIVE: Determine the most accurate and cost effective radiographic
evaluation for nasal dermoids. Determine the best surgical approach for
excision of nasal dermoids. DESIGN: Retrospective chart review. SETTING:
Division of Pediatric Otolaryngology, Children's Hospital and Health
Center, San Diego, California. PARTICIPANTS: All patients with nasal
dermoids evaluated and treated from 1990 to 2000. INTERVENTION:
Preoperative radiographic evaluation and surgical excision. OUTCOME
MEASURES: Accuracy of CT and MRI correlated with surgical findings and
results. RESULTS: Ten patients were identified with the diagnosis of
nasal dermoid. The age at diagnosis ranged from 0 to 24 months, with a
mean of 3 months. Six children presented with masses located at the
glabella, three patients presented with masses located at the nasal
dorsum and one presented with a mass at the nasal tip. Six children
underwent a computed tomogram with contrast of the head. Seven children
underwent a MRI study of the head. Three children underwent an initial
CT followed by MRI. Twenty percent of children were found to have
intracranial extension. CT scan accurately diagnosed intracranial
extension in one case, was indeterminate in a second case and falsely
positive in a third case. MRI correctly diagnosed intracranial extension
in two cases and had no false positive or false negative results. No
children were found to have associated intracranial anomalies. In the
early years of the review, a simple excision was made over the mass with
blunt and sharp dissection for removal. (An external rhinoplasty
incision is now used with better exposure and improved cosmetic
results.) In cases with intracranial communication, a combined approach
of external rhinoplasty and craniotomy was used. CONCLUSIONS: MRI alone
is the most cost effective and accurate means of evaluating nasal
dermoids and is essential for preoperative planning. The surgical
approach of choice is external rhinoplasty for both cosmetic reasons and
exposure of nasal dermoids with and without intracranial extension.
7
UI - 11850528
AU - Delbrouck C; Doyen I; Belot N; Decaestecker C; Ghanooni R; de Lavareille
TI -
A; Kaltner H; Choufani G; Danguy A; Vandenhoven G; Gabius HJ; Hassid S;
Kiss R
Galectin-1 is overexpressed in nasal polyps under budesonide and
inhibits eosinophil migration.
SO - Lab Invest 2002 Feb;82(2):147-58
AD - E.N.T. Department, Erasmus University Hospital, Brussels, Belgium.
Because of the importance of galectins for various cellular activities,
the influence of the glucocorticoid budesonide on the level of
expression of galectins-1 and -3 was investigated in human nasal
polyposis. Ten nasal polyps obtained from surgical resection were
maintained for 24 hours in the presence of various concentrations of
budesonide. As quantitatively demonstrated by means of computer-assisted
microscopy, 250 ng/ml (the highest dose tested) induced a pronounced
increase of galectin-1 expression. This feature was observed in nasal
polyps from allergic patients but not in those from nonallergic
patients. Since eosinophils represent the main inflammatory cell
population in nasal polyps, we investigated the effect of galectin-1 on
their migration levels by means of quantitative phase-contrast
computer-assisted videomicroscopy. Our results show that galectin-1
(coated on plastic supports) markedly reduced the migration levels of
eosinophils in comparison to P-selectin. On the cellular level, marked
modifications in the polymerization/depolymerization dynamics of the
actin cytoskeleton (as revealed by means of computer-assisted
fluorescence microscopy) and, to a much lesser extent, an increase in
the adhesiveness of eosinophils to tested substrata were detectable. The
present study therefore reveals a new galectin-1-mediated mechanism of
action for glucocorticoid-mediated anti-inflammatory effects.
8
UI - 11843934
AU - Fahy C; Jones NS
TI -
Nasal polyposis and facial pain.
SO - Clin Otolaryngol 2001 Dec;26(6):510-3
AD - Department of Otorhinolaryngology, Head and Neck Surgery, University of
Nottingham, Nottingham NG7 2UH, UK.
A cohort of 973 patients with symptoms of rhinosinusitis and/or facial
pain was followed up for a mean of 2 years 2 months and, within this,
was a group of 220 with nasal polyps. Only 39 (18%) had pain or pressure
as a symptom. Out of the 220 with nasal polyps, 190 had polyps without
any purulent secretions and, of these, only 5 (2.6%) had pain
attributable to their paranasal sinus disease. Ten out of the 15 with
pain and polyps without pus were found to have pain as a result of
neurological or medical cause after endoscopic sinus surgery and a trial
of medical nasal treatment and, where necessary, drugs to treat
neurological conditions. Thirty patients (13.6%) had nasal polyposis and
purulent secretions, and, within this subgroup, 24 (79%) had pain as
well. Of the 24 with pain and purulent secretions, 19 (80%) responded to
treatment for their paranasal sinus disease, a far higher proportion
than with nasal polyps without pus. In conclusion, in patients who have
nasal polyps without purulent secretions, be cautious about attributing
any symptoms of facial pain or pressure as being due to their paranasal
sinuses as it is more probable that it is coincidental and the result of
a neurological cause.
9
UI - 11852918
AU - Pabuccuoglu U; Ozkara E; Lebe B
TI -
Hobnail haemangioma occurring on the nasal dorsum.
SO - Br J Dermatol 2002 Jan;146(1):162-4
10
UI - 10823646
AU - Pruna X; Ibanez JM; Serres X; Garriga V; Barber I; Vera J
TI -
Antrochoanal polyps in children: CT findings and differential diagnosis.
SO - Eur Radiol 2000;10(5):849-51
AD - Department of Radiology, Hospital General de Granollers, Barcelona,
Spain.
Antrochoanal polyp (Killian polyp) is an infrequent, usually solitary,
benign, slowly growing lesion that arises from the maxillary antrum and
reaches the choana. These polyps have a discrete male predominance and
are diagnosed usually between the third and the fifth decades of life.
This report is based on three cases of antrochoanal polyp, occurring in
the pediatric group, and the objective is to demonstrate their different
CT characteristics, principal differential diagnoses, and potential
complications. We emphasize that in all three cases of our series the
growth of the polyp to the choana is through the accessory ostium.
11
UI - 11218038
AU - Grainger AJ; Zammit-Maempel I
TI -
Antrochoanal polyps in children.
SO - Eur Radiol 2001;11(2):347
12
UI - 11868471
AU - Windfuhr JP; Ott G
TI -
Extramedullary plasmacytoma manifesting as a palpable mass in the nasal
cavity.
SO - Ear Nose Throat J 2002 Feb;81(2):110-4
AD - Department of Otorhinolaryngology-Plastic Head and Neck Surgery, St.
Anna Hospital, Albertus Magnus Str. 33, 47259 Duisburg, Germany.
jwindfuhr@aol.com
We report a rare case of plasmacytoma of the nasal cavity in a
60-year-old man. The patient had a history of a steadily growing and
palpable mass in the opening of the left nostril. The tumor was found to
be localized, and it was identified as an extramedullary plasmacytoma.
The patient underwent therapy with 55 Gy of radiation. Six months
following the cessation of radiotherapy, the size of the tumor had not
changed. The mass was then completely excised under microscopic vision.
Histopathologic examination identified the growth as a plasmacytoma with
monotypic light-chain expression. To optimize the management of patients
with an extramedullary plasmacytoma of the head and neck,
interdisciplinary management is mandatory.
13
UI - 11775513
AU - Christmas DA Jr; Marotta JC; Yanagisawa E
TI -
Nasal malignancy masquerading as polyposis: importance of biopsy in
powered endoscopic sinus surgery.
SO - Ear Nose Throat J 2001 Dec;80(12):856-7
AD - Department of Otolaryngology, University of South Florida College of
Medicine, Tampa, Fla., USA.
14
UI - 11783097
AU - Hu W; Chen M; Luo F
TI -
[Multivariate analysis of prognosis of patients with stage IE
non-Hodgkin's lymphomas of the nasal cavity]
SO - Zhonghua Zhong Liu Za Zhi 2001 May;23(3):240-3
AD - Cancer Center, Sun Yet-sen University of Medical Sciences, Guangzhou
510060, China.
OBJECTIVE: To analyze the factors affecting prognosis of patients with
primary non-Hodgkin's lymphomas (NHL) of the nasal cavity. METHODS: From
Jan. 1968 to Dec. 1997, a total of 71 patients with stage IE(Ann Arbor
staging system, 1971) primary non-Hodgkin's lymphomas of the nasal
cavity were treated in the Tumor Hospital of Sun Yat-sen University of
Medical Sciences. In 37 of the 71 patients, the lesions were limited in
the nasal cavity (limited IE), and in 34, the lesions were locally
extended involving the adjacent structures (extended IE) Forty-four
patients were treated with radiotherapy and 27 with radiotherapy plus
chemotherapy. Survival analysis was done by the Kaplan-Meier method, and
multivariate analysis was carried out using Cox proportional hazard
model. RESULTS: The 5- and 10-year survival rate was 71.9% and 59.7%
respectively in patients who had complete response to radiotherapy. The
5- and 10-year survival rate was both 13.9% in patients who had residual
tumors after treatment. The 5- and 10-year survival rate was 69.8% and
56.7% in patients with limited IE lesions, but 40.7% and 35.6% in those
with extended IE lesions. The prognosis was better in younger (< 44
years) than in older patients. The 10-year survival rate of patients
received radiotherapy alone and those combined with chemotherapy was
52.0% and 75.0% respectively for limited IE as compared to 37.6% and
45.0% for extended IE. B symptoms did not significantly affect clinical
outcome. Multivariate analysis showed that the immediate response to
radiotherapy, invasion of the primary tumor outside of nasal cavity and
patients' age were independent prognostic factors. CONCLUSION:
Radiotherapy is the main treatment method for stage IE non-Hodgkin's
lymphoma of the nasal cavity. Addition of chemotherapy can improve
long-term survival. The local tumor response to radiotherapy, clinical
staging and age of patients have significant influence on patients'
prognosis.
15
UI - 11811057
AU - Coste A; Triglia JM; Nicollas R; Chazalette JP; Ravilly S
TI -
[Management of otorhinolaryngeal manifestations]
SO - Arch Pediatr 2001 Dec;8 Suppl 5():901s-905s
AD - Service d'ORL et de chirurgie cervico-faciale des hopitaux intercommunal
et Henri-Mondor de Creteil, France.
16
UI - 11150125
AU - Eusebi V
TI -
Microglandular adenosis arising in a chronic paranasal sinusitis.
SO - Histopathology 2000 Nov;37(5):474
17
UI - 11878205
AU - Kusters S; Schuligoi R; Huttenbrink KB; Rudert J; Wachs A; Szelenyi I;
TI -
Peskar BA
Effects of antihistamines on leukotriene and cytokine release from
dispersed nasal polyp cells.
SO - Arzneimittelforschung 2002;52(2):97-102
AD - Pulmonary Pharmacology, Corporate Research ASTA Medica
AG/Arzneimittelwerk Dresden GmbH, Radebeul, Germany.
In this study the effects of antihistamines on the release of
eicosanoids and the pro-inflammatory cytokine tumor necrosis factor
alpha (TNF alpha) were compared. Enzymatically dispersed cells from
human nasal polyps served as an in vitro model of chronic respiratory
mucosal inflammation. Nasal polyp cells (2 x 10(5)/ml) were sensitized
with human IgE pre-incubated azelastine (CAS 58581-89-8), terfenadine
(CAS 50679-08-8), levocabastine (CAS 79516-68-0) or cetirizine (CAS
83881-51-0), and stimulated with anti-human immunoglobulin E (IgE).
Thromboxane B2 (TBX2) and leukotriene C4 (LTC4) were measured by
radioimmunoassay (RIA), TNF alpha by enzyme-linked immunosorbent assay
(ELISA). Data represent mean values of % inhibition estimated from the
untreated positive control or mean IC50 (n = 5). Azelastine and
terfenadine inhibited TNF alpha release with IC50 values of 6.2 mumol/l
and 4.3 mumol/l, respectively. Terfenadine reduced TXB2 release by 37
+/- 15%, and LTC4 release was decreased by azelastine and terfenadine
very potently by 86% and 100%, respectively. Azelastine shows
anti-inflammatory properties in therapeutically relevant concentrations
as assessed by its ability to reduce TNF alpha release as well as its
ability to inhibit LTC4 production in allergically stimulated human
nasal polyp cells.
18
UI - 11843675
AU - Park SS
TI -
The single-stage forehead flap in nasal reconstruction: an alternative
with advantages.
SO - Arch Facial Plast Surg 2002 Jan-Mar;4(1):32-6
AD - Department of Otolaryngology-Head and Neck Surgery, University of
Virginia Medical Center, PO Box 800713, Charlottesville, VA 22908-0713,
USA. ssp8a@virginia.edu
OBJECTIVE: To review the single-stage forehead flap for patient
selection, technique, and main outcome measures. METHODS: Patients
undergoing nasal reconstruction between January 1, 1995, and June 30,
2000, were reviewed from medical records, photographs, and personal
communication. All work was performed in an academic medical center.
RESULTS: Fifty-one patients had a forehead flap for nasal
reconstruction, of which 10 (20%) were repaired in a single stage. All
patients had no evidence of small vessel disease, eg, hypertension,
diabetes mellitus, or tobacco use. Nasal defects were limited to the
upper two thirds of the nose. The technique is modified from the
original description by creating a unilateral, subcutaneous pedicle,
wide undermining, and partial resection of the procerus muscle. One
patient had superficial epidermolysis at the distal tip of the flap. The
remaining 9 patients maintained complete viability with satisfactory
outcomes. One debulking procedure was performed to the glabellar area
for aesthetic reasons. The average interval for returning to work was
6.6 days compared with the minimal 3 weeks for conventional interpolated
flaps. CONCLUSION: In select cases, a single-stage, island midline
forehead flap can be used safely as an advantageous alternative to the
conventional interpolated forehead flap.
19
UI - 11717906
AU - Li S; Zhang Q; Yang Z
TI -
[Measurement of blood flow in nasal mucosa]
SO - Zhonghua Er Bi Yan Hou Ke Za Zhi 1998 Jun;33(3):156-7
AD - Third Clinical College of Bethune University of Medical Sciences,
Changchun 130031.
OBJECTIVE: To determine the amount of blood flow in the human nasal
mucosa and its change in patients with nasal polyps and allergic
rhinitis. METHODS: Using the Ameflow-H2, the amount of blood flow in
nasal mucosa was examined in 98 normal adults, 18 cases of nasal polyps
and 14 cases of allergic rhinitis before and after application of the
vaso constrictor. RESULT: Before the application of the vaso
constrictor, blood flow of nasal mucosa of patients with nasal polyps
and allergic rhinitis was lower than that of healthy people (P < 0.01).
After using the vaso constrictor, the amount of blood flow was decreased
in all cases with a significant decrease in patients with nasal polyps.
CONCLUSION: Ameflow-H2 may be the best tool to measure nasal blood flow
than other devices. The method is technically simple, less traumatic,
and repeatable.
20
UI - 11870343
AU - Ziroli NE; Na H; Chow JM; Stankiewicz JA; Samter M; Young MR
TI -
Aspirin-sensitive versus non-aspirin-sensitive nasal polyp patients:
analysis of leukotrienes/Fas and Fas-ligand expression.
SO - Otolaryngol Head Neck Surg 2002 Feb;126(2):141-6
AD - Department of Otolaryngology-Head and Neck Surgery, Stritch School of
Medicine, Loyola University Medical Center, Maywood, Illinois 60153,
USA.
OBJECTIVE: The goal of the present study was to identify levels of
leukotrienes released by leukocytes and nasal polyps from
aspirin-sensitive patients (ASPs) and non-aspirin-sensitive patients
(NASPs) after exposure to various concentrations of aspirin. Eosinophil
expressions of apoptosis regulators were also compared. STUDY DESIGN AND
SETTING: Leukotriene release from nasal polyps and leukocytes of ASPs
and NASPs was measured after exposure to differing concentrations of
aspirin. Eosinophils were analyzed for Fas and Fas ligand receptors
using flow cytometry. RESULTS: NASPs showed increased leukotriene
release from nasal polyps on increased aspirin exposure. Polyps from
ASPs did not show any change. ASPs showed greater leukotriene release
from blood on increasing aspirin exposure compared with NASPs. Flow
cytometric analysis showed eosinophils in the peripheral blood of ASPs
have decreased Fas expression compared with those of NASPs. CONCLUSIONS:
This study showed differences in leukotriene release and eosinophil
apoptosis between ASPs and NASPs. SIGNIFICANCE: These findings suggest a
role of leukotrienes and eosinophils in aspirin sensitivity mechanisms
in blood.
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