National Cancer Institute®
Last Modified: June 1, 2002
UI - 11896775
AU - Kakinuma H; Iwasawa U; Honjoh M; Koura T
TI - A composite nasolabial flap for an entire ala reconstruction.
SO - Dermatol Surg 2002 Mar;28(3):237-40
AD - Department of Dermatology, Surugadai Nihon University Hospital, Itabashi Nihon University Hospital, Tokyo, Japan.
BACKGROUND: It is difficult to reconstruct an entire alar defect. We report a case of an entire alar reconstruction carried out in two stages with a composite nasolabial flap lined with retroauricular skin and supported with the attached conchal cartilage. OBJECTIVE: A composite nasolabial flap was applied for reconstruction of entire alar defect in this patient. METHODS: The lining skin for the flap was obtained from retroauricular region acceptable to the patient, and the conchal cartilage was used simultaneously for support and as the attachment for the lining skin. The flap was then replaced and secured. Half a year later, the flap was flipped and transferred to the alar defect as a second step. RESULTS: The final shape and texture were satisfactory. All procedures were performed under local anesthesia. CONCLUSION: Our design of composite flap has been successfully utilized to repair an entire alar defect with cosmetically and functionally good results, minimizing the donor area and the resulting operation scars. This composite nasolabial flap is thought to be the best choice of a flap for an entire alar defect reconstruction.
UI - 11957292
AU - Ndiaye M; Hane AA; Ndir M; Ba O; Cissokho S; Kandji M; Ndiaye S; Diatta
TI - A; Niang A; Dia Y; Diouf R [Fernand Widal syndrome: apropos of 2 cases]
SO - Dakar Med 1999;44(2):232-5
AD - Service de Pneumophtisiologie C.H.U. de FANN BP: 5035 Dakar/Fann.
The Fernand Widal syndrome combines a nasal polyposis, an asthma and aspirin sensitivity. It remains a nosological entity often unrecognized because of the trivialization of aspirin in-take on the one hand the other its etiopathogenesis which has not yet been clarified because of the inhibition of the cyclo-oxygenase. In actual fact the aspirin molecule has yet to reveal all its secrets (advantages and disadvantages). We report 2 cases of Fernand Widal syndrome observed in 2 women in their thirties with a notion of atopy in one at the Pneumophtisiology clinic at the Fann University Hospital in Dakar. The confirmed diagnosis was based on oral provocative test in addition to suggestive clinical signs which emphasize the classical triad with a chronological appearance more or less typical. The best treatment could combine inhaled corticotherapy, nasalization of sinus cavities, antihistaminics, no aspirin in take and educating the patient.
UI - 12003591
AU - Kimura T; Majima Y; Guo Y; Yoshida T
TI - The effect of growth factors on the proliferation and differentiation of human nasal gland cells.
SO - Arch Otolaryngol Head Neck Surg 2002 May;128(5):578-82
AD - Department of Otorhinolaryngology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.
OBJECTIVE: To elucidate a mechanism of proliferation and differentiation of nasal gland cells, we established a serum-free 3-dimensional culture system for human nasal gland (HNG) cells and examined the effects of epidermal growth factor, keratinocyte growth factor, and retinoic acid on proliferation and differentiation of cultured HNG cells. MATERIALS AND METHODS: Nasal polyps were obtained from patients undergoing endoscopic endonasal sinus surgery. The HNG cells were cultured under a monolayer culture and transferred to a collagen-embedded culture using RPMI 1640 medium containing transferrin, insulin, hydrocortisone, retinoic acid, epidermal growth factor, and keratinocyte growth factor. Cell growth was measured by bromodeoxyuridine incorporation assays. To measure cell differentiation, the percentage of cells containing secretory granules, which were stained with Alcian blue in cytoplasm, was determined. RESULTS: In the serum-free 3-dimensional culture, the HNG cells showed ductal structures containing secretory products in a lumen. The addition of epidermal growth factor promoted the proliferation of HNG cells in its optimal concentrations, and keratinocyte growth factor also enhanced the proliferation of HNG cells. Conversely, the differentiation of HNG cells was not dependent on epidermal growth factor and keratinocyte growth factor. Retinoic acid suppressed the proliferation, but promoted the differentiation of HNG cells. CONCLUSION: Our culture system could be useful for studying the effects of various growth factors and cytokines on HNG proliferation and differentiation to better understand the mechanisms of growth and morphogenesis of nasal glands.
UI - 11997789
AU - Fetoni AR; Galli J; Frank P; Marmiroli L; Motta S; Almadori G
TI - Management of advanced adenocarcinoma of maxillary sinus in a young woman during pregnancy: a case report.
SO - Otolaryngol Head Neck Surg 2002 Apr;126(4):432-4
AD - Institute of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy. firstname.lastname@example.org
UI - 11997792
AU - Hamdan AL; Kahwagi G; Farhat F; Tawii A
TI - Oncocytoma of the nasal septum: a rare cause of epistaxis.
SO - Otolaryngol Head Neck Surg 2002 Apr;126(4):440-1
AD - Department of Otolaryngology-HNS, American University of Beirut Medical Center, New York, NY 10022, USA. email@example.com
UI - 11997794
AU - Lecanu JB; Arkwright S; Halimi PH; Trotoux J; Bonfils P
TI - Multifocal malignant paraganglioma of the paranasal sinuses: a case report.
SO - Otolaryngol Head Neck Surg 2002 Apr;126(4):445-7
AD - Department of Otolaryngology-Head and Neck Surgery, Faculty Necker-Enfants Malades, University Rene Descartes, European Hospital Georges Pompidou, Paris.
UI - 12024997
AU - Yanagisawa E; Yanagisawa K
TI - Endoscopic view of a frontochoanal polyp.
SO - Ear Nose Throat J 2002 May;81(5):306
AD - Section of Otolaryngology, Yale University School of Medicine, Hospital of St. Raphael, New Haven, USA.
UI - 12025003
AU - Matthews B; Whang C; Smith S
TI - Endoscopic resection of a nasal septal chondrosarcoma: first report of a case.
SO - Ear Nose Throat J 2002 May;81(5):327-9
AD - Department of Otolaryngology, Baptist Medical Center, Wake Forest University, Winston-Salem, N.C., USA. firstname.lastname@example.org
Advances in endoscopic sinus surgery technique and technology have provided the otolaryngologist with a wide array of surgical options for the management of nasal and paranasal sinus diseases that were once limited to procedures requiring invasive surgery. We describe the case of a patient with a chondrosarcoma of the posterior nasal septum that was resected endoscopically. There have been fewer than 30 reports in the English-language literature of chondrosarcomas arising at this location, and the reported approaches to surgical excision in these case involved craniofacial procedures, facial degloving, facial splitting, and maxillectomy techniques. Until now, no case of endoscopic removal has been reported.
UI - 11902539
AU - Dulguerov P; Allal AS; Calcaterra TC
TI - Esthesioneuroblastoma: a meta-analysis and review.
SO - Lancet Oncol 2001 Nov;2(11):683-90
AD - Division of Head and Neck Surgery, Geneva University Hospital, Switzerland. email@example.com
Our objective was to review recent developments in diagnosis, staging, and treatment of esthesioneuroblastoma (ENB). A meta-analysis of publications between 1990 and 2000 was carried out, and studies were classified according to their main subject: origin/aetiology of ENB, histopathological diagnosis, and treatment. Data so far point to the basal progenitor cells of the olfactory epithelium as the origin of ENB. Histopathological diagnosis remains difficult and is based on results of antigen expression detected through a panel of antibodies by immunohistochemistry. RT-PCR of HASH expression could be a specific marker of ENB. Overall and disease-free survival at 5 years averaged 45% (SD 22) and 41% (SD 21) in the studies included in the meta-analysis. Survival in Hyams' grades I-II was 56% (SD 20) compared with 25% (SD 20) in grades III-IV (odds ratio 6.2). In patients with metastases in cervical lymph nodes (on average 5% of the total) survival was 29%, compared with 64% for patients with N0 disease (odds ratio 5.1). Survival according to treatment modalities was 65% for surgery plus radiotherapy, 51% for radiotherapy and chemotherapy, 48% for surgery, 47% for surgery plus radiotherapy and chemotherapy, and 37% for radiotherapy alone. The histopathological grading according to Hyams and the presence of cervical lymph-node metastases emerged as prognostic factors. A combination of surgery and radiotherapy seems to be the optimum approach to treatment. The exact role of chemotherapy in treatment protocols is still unclear. The role of elective neck dissection is unclear.
UI - 11938847
AU - Kong H; Dong Z; Guo Y
TI - [Expression of intercellular adhesion molecules in nasal polyps tissue and its significance]
SO - Zhonghua Er Bi Yan Hou Ke Za Zhi 1998 Dec;33(6):350-2
AD - Third Clinical College, Bethune University of Medical Sciences, Changchun, 130031.
OBJECTIVE: To study the expression of intercellular adhesion molecule-1/lymphocyte function-associated antigen-1 in nasal polyps tissue and its significance. METHODS: Frozen sections of 9 normal nasal mucosa and 19 nasal polyp samples were studied with immunohistochemical technique and immunohistochemical and MGG dual staining method with ICAM-1 and LFA-1 monoclone antibodies. RESULTS: Expression of ICAM-1 and LFA-1 were stronger in nasal polyps tissue than in the normal nasal mucosa, and there is positive relationship between the expression of ICAM-1 and the expression of LFA-1 on eosinophils. CONCLUSION: High expression of ICAM-1 and LFA-1 in nasal polyps tissue showed that interaction of ICAM-1/LFA-1 may participate in the inflammatory reaction and prompt adhesion and migration of eosinophils. High expression of LFA-1+ on eosinophils may play an important role in the pathogens of nasal polyps.
UI - 11994707
AU - Mullol J; Fernandez-Morata JC; Roca-Ferrer J; Pujols L; Xaubet A;
TI - Benitez P; Picado C Cyclooxygenase 1 and cyclooxygenase 2 expression is abnormally regulated in human nasal polyps.
SO - J Allergy Clin Immunol 2002 May;109(5):824-30
AD - Institut d'Investigacions Biomediques August Pi I Sunyer, Institut Clinic de Pneumologia I Cirurgia Toracica, Hospital Clinic, Barcelona, Spain.
BACKGROUND: There is evidence that impairment of prostanoid metabolism might be involved in the pathogenesis of nasal polyps (NPs). Prostanoids are synthesized by 2 cyclooxygenase (Cox) enzymes, one constitutive (Cox-1) and another inducible (Cox-2). OBJECTIVE: The aim of these studies was to investigate Cox-1 and Cox-2 regulation in NPs of aspirin-tolerant human patients compared with that seen in nasal mucosa (NM). METHODS: Cultured explants from human NPs and healthy mucosa from patients undergoing polypectomy and corrective nasal surgery, respectively, were examined for Cox-1 and Cox-2 expression by means of semiquantitative competitive PCR and Western blotting. RESULTS: Cox-1 mRNA was spontaneously upregulated in cultured NM but not in NPs. A spontaneous but delayed upregulation of Cox-2 mRNA was found in NPs (24 hours) compared with that seen in NM (6 hours). After cytokine stimulation (IFN-gamma, IL-1beta, and TNF-alpha), the induction of Cox-2 mRNA and protein was also faster in NM (1 hour) than in NPs (4 hours). CONCLUSION: These data showing an abnormal regulation of Cox-1 and Cox-2 in NPs from aspirin-tolerant patients reinforce the concept that prostanoid metabolism might be important in the pathogenesis of inflammatory nasal diseases and suggest a potential role for this alteration in the formation of NPs.
UI - 11952703
AU - Chang SE; Lee SY; Choi JH; Sung KJ; Moon KC; Koh JK
TI - Cutaneous dissemination of nasal NK/T-cell lymphoma with bone marrow, liver and lung involvement.
SO - Clin Exp Dermatol 2002 Mar;27(2):120-2
AD - Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, Korea. firstname.lastname@example.org
We describe a 32-year-old Korean man with a primary nasal natural killer (NK)/T-cell lymphoma (NKTCL). Combination chemotherapy and radiotherapy resulted in initial complete remission. However, cutaneous dissemination to the trunk and proximal extremities occurred 16 months later and further investigations revealed involvement of the liver, lymph nodes, lung and bone marrow. Nasal CD56+ NKTCL is mostly localized to the nasal area but also shows a predilection for other sites, such as skin. Cutaneous dissemination may be an indicator of widespread metastasis to internal organs and is consistently fatal.
UI - 11981188
AU - Denk MJ; Ajkay N; Yuan X; Rosenblum RS; Freda N; Magee WP Jr
TI - Surgical treatment of nasal hemangiomas.
SO - Ann Plast Surg 2002 May;48(5):489-94; discussion 494-5
AD - Eastern Virginia Medical School, Norfolk, VA, USA. email@example.com
The treatment of nasal hemangiomas continues to be controversial. The authors' experience with early surgical treatment of nasal hemangiomas is presented. This retrospective study includes 11 patients. Surgical intervention consisted of excision of the nasal hemangioma and reconstruction by local tissue transfer or rearrangement. Age at surgery ranged from 10 months to 6.5 years (mean age, 2.2 years). All patients have acceptable nasal contour and have demonstrated excellent nasal growth. The authors' experience demonstrates that early surgical intervention is an acceptable alternative for the management of nasal hemangiomas.
UI - 12000695
AU - Zabel A; Thilmann C; Zuna I; Schlegel W; Wannenmacher M; Debus J
TI - Comparison of forward planned conformal radiation therapy and inverse planned intensity modulated radiation therapy for esthesioneuroblastoma.
SO - Br J Radiol 2002 Apr;75(892):356-61
AD - Department of Radiotherapy, German Cancer Research Center, INF280, 69120 Heidelberg, Germany.
The purpose of this study was to compare dose distribution of inverse planned intensity modulated radiation therapy (IMRT) with that of conformal radiation therapy (SCRT) in the treatment of esthesioneuroblastoma, and to report initial clinical results. 13 patients with esthesioneuroblastoma were planned both with IMRT and SCRT using complete three-dimensional data sets. A target dose of 60 Gy was prescribed. We performed a detailed dose volume histogram analysis. Dose coverage was equal in both plans while dose distribution was more conformal to the target volume with IMRT. Mean and maximum dose of the brain stem, chiasm, optic nerves and orbits were lower using IMRT than SCRT. The reduction was significant regarding orbit and optic nerve (p<0.05). IMRT was superior in sparing of organs at risk compared with SCRT. The additional sparing by IMRT was positively correlated to the size of the target volume, which was evident with target volumes above 200 cm3. Treatment time was approximately 20 minutes per fraction using IMRT compared with 15 minutes per fraction using SCRT. We conclude that IMRT is both feasible and a valuable tool for more conformal dose distribution in the treatment of esthesioneuroblastoma and to spare organs at risk that are in critical relationship to the tumour. This advantage could be seen especially well in complex shaped target volumes above 200 cm3. Thus, using IMRT, risk of complications may be minimized and local tumour control may be increased.
UI - 12023587
AU - Finke NM; Lae ME; Lloyd RV; Gehani SK; Nascimento AG
TI - Sinonasal desmoplastic small round cell tumor: a case report.
SO - Am J Surg Pathol 2002 Jun;26(6):799-803
AD - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
A case of sinonasal desmoplastic small round cell tumor in a 21-year-old woman is presented. The tumor possessed the diagnostic histologic, immunohistochemical, and genetic characteristics of desmoplastic small round cell tumor. Histologically, the tumor was composed of nests of tumor cells surrounded by a desmoplastic stroma. Immunohistochemical staining was positive for keratin, vimentin, desmin, and, focally, neuron-specific enolase. The desmin immunopositivity was of a classic dot-like perinuclear pattern. RT-PCR analysis showed the fusion transcript resulting from the t(11;22)(p13;q12) reciprocal translocation. This case of sinonasal desmoplastic small round cell tumor, the third reported case not associated with a serosal surface, further obscures the nature and histogenesis of this entity.
UI - 12044062
AU - Altemani A; Barbosa AC; Kulka M; Takahashi T; Endo L; Vassallo J;
TI - Lorand-Metze I Characteristics of nasal T/NK-cell lymphoma among Brazilians.
SO - Neoplasma 2002;49(1):55-60
AD - Department of Pathology, Faculty of Medicine, State University of Campinas, SP, Brazil. firstname.lastname@example.org
Nasal T/NK-cell lymphomas are highly associated with Epstein-Barr virus (EBV). They are more frequent in Asia than in Western countries. In Central and South America there are few studies about nasal T/NK-cell lymphoma and they have shown a strong predominance of this phenotype in Native American descents, supporting the hypothesis of a racial predisposition for the disease. We studied the lymphomas involving midline facial region at a Brazilian institution. T/NK cell lymphomas (16/25) were more frequently found compared to B lymphomas (9 cases, all B large cell). T/NK cell lymphomas involved predominantly the nasal region. Histologically they showed angioinvasion and necrosis. All of them were positive for CD3 and CD56 and showed numerous tumor cells labeled by EBER-1. Although disease was localized in 61% at diagnosis, there was no tendency to cure. The racial distribution of patients with T/NK-cell phenotype was similar to that found in B-cell lymphomas. EBV was more frequently found in adenoids than in palatine tonsils. In inflammatory lesions of the nasal and palatal regions EBV was not found. In the present study the relative frequency of T/NK versus B cell sinonasal lymphomas was high and similar to that observed in other Latin American countries. However, there was not any racial association with T/NK-cell phenotype and the tumor showed an agressive behavior similar to that reported in Asia. The high frequency of EBV-positive lymphocytes in nasopharyngeal lymphoid tissue (adenoids) suggests that they could serve as a reservoir for the virus.
UI - 11987838
AU - Skladzien J; Nowogrodzka-Zagorska M; Obtulowicz K; Gawlik J;
TI - Wierzchowski W [Drug allergy among patients suffering from nasal polyps]
SO - Przegl Lek 2001;58(11):975-8
AD - Klinika Otolaryngologii Collegium Medicum Uniwersytetu Jagiellonskiego, 31-501 Krakow, ul. Sniadeckich 2.
The study was performed in order to evaluate quantity and morphology of nasal polyps in patients with diagnosed drug allergy to aspirin, antibiotics, polocain, procain and other drugs. The study included 60 patients (27 females, 33 males aged between 18-69 years). Nasal polyp morphology was examined under electron microscope and light microscope. Morphological evaluation of epithelial and subepithelial structures was done under light microscope, taking not of inflammatory infiltration type, basal membrane, as well as degree of intestinal edema. Evaluation of epithelial cell type, their relative proportion, as well as area percentage covered by cilium, microvilli and squamous epithelium was done under electron microscope. Polyps in patients with idiosyncrasy to polish aspirin and sodium metamizole (12 patients) featured increased eosinophilic infiltration, thickened basal membrane, with elevated eosinophil percentage differential count. The epithelial percentage area was covered by squamous cells without villi. Polyps associated with idiosyncrasy to polish aspirin differed morphology compared to polyps originality from patients allergic to other medications. On the other hand polyps from patients allergic to other drugs, such as: penicillin, procainamide were morphologically (electron light microscope, light microscope) similar to those polyps caused by inflammatory factors.
UI - 12006758
AU - Morimoto K; Takemoto O; Nishikawa M; Umegaki M; Nishino A
TI - Nasal dermal sinus with a dermoid cyst.
SO - Pediatr Neurosurg 2002 Apr;36(4):218-9
AD - Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka 594-1101, Japan. email@example.com
UI - 12040755
AU - Zabel A; Thilmann C; Milker-Zabel S; Schlegel W; Zuna I; Wannenmacher M;
TI - Debus J The role of stereotactically guided conformal radiotherapy for local tumor control of esthesioneuroblastoma.
SO - Strahlenther Onkol 2002 Apr;178(4):187-91
AD - Department of Radiotherapy, German Cancer Research Center, Heidelberg, Germany. A.Zabel@dkfz.de
BACKGROUND: In a retrospective analysis we compared conventional radiotherapy and stereotactically guided conformal radiotherapy (SCRT) in patients with esthesioneuroblastoma. PATIENTS AND METHODS: Between 1991 and 1999 14 patients with esthesioneuroblastoma underwent radiotherapy at our institution. Median follow-up was 30 months (range 12-107 months). Treatment included adjuvant radiotherapy (9), adjuvant radiochemotherapy (3) or radiotherapy alone (2). Eight patients received SCRT with 3-D treatment planning. For comparison a standard three-field plan for these patients and dose-volume histogram analyses were performed. Median total dose was 64 Gy using SCRT and 56 Gy with standard technique. RESULTS: Local tumor control rate was 50% with conventional radiotherapy and 75% with SCRT. Overall survival was 33.3% and 62.5%, respectively. Target coverage could be improved statistically significant (p < 0.05) and dose to critical structures was reduced using SCRT. Greatest differences were seen regarding volume above the 30%-isodose as well as mean dose of brain stem (p < 0.05). A reduction of maximum dose was seen using SCRT as consequence of a more homogeneous treatment. CONCLUSIONS: SCRT improves target coverage and sparing of organs at risk. Our clinical data although with low patient numbers suggest that the technical advantage translates into a clinical advantage. The use of SCRT appears to facilitate higher dose prescriptions without risking major acute and late side effects. Thus the risk of complications in this area is minimized. Adjuvant radiotherapy is a save and effective treatment modality for local control of esthesioneuroblastoma.
UI - 11966709
AU - Ling TC; Harris M; Craven NM
TI - Epstein-Barr virus-positive blastoid nasal T/natural killer-cell lymphoma in a caucasian.
SO - Br J Dermatol 2002 Apr;146(4):700-3
AD - Department of Dermatology, Burnley General Hospital, Burnley BB10 2PQ, U.K.
T/natural killer (NK)-cell lymphoma is a subtype of non-Hodgkin's lymphoma, with frequent cutaneous involvement; it follows an aggressive course. Most cases are reported in Asia, and typically present with nasopharyngeal involvement. There is a distinct variant known as blastoid T/NK-cell lymphoma, which affects elderly, non-Asian patients, with absence of nasal involvement. We report a middle-aged caucasian man who had blastoid T/NK-cell lymphoma with nasal involvement.
UI - 11977352
AU - Rozylo-Kalinowska I
TI - Imaging diagnostics strategy in maxillary sinus neoplasms.
SO - Ann Univ Mariae Curie Sklodowska [Med] 2001;56():423-9
AD - 2nd Department of Medical Radiology, Medical University of Lublin.
Malignant neoplasms of maxillary sinuses are a serious diagnostic and therapeutic challenge, so the objective of a clinician is the planning of a cost-effective strategy promptly leading to proper diagnosis and the onset of treatment. Thus the aim of the paper was the elaboration of diagnostic strategy in maxillary neoplasms. There were analyzed 163 case records of 78 patients with maxillofacial neoplasms. The number and sequence of the conventional radiograms as well as diagnostic imaging methods were registered. There was proposed an algorithm of application of imaging techniques in diagnostics of neoplasms of maxillary antra. It was found that conventional X-rays are still valuable in screening for sinus pathology and as indication of the necessity of performing other imaging examinations. Computed tomography and magnetic resonance are complementary in visualization of pathologic masses and bone tissue destruction.
UI - 12044140
AU - Keller JJ; Westerman AM; de Rooij FW; Wilson JH; van Dekken H;
TI - Giardiello FM; Weterman MA; Offerhaus GJ Molecular genetic evidence of an association between nasal polyposis and the Peutz-Jeghers syndrome.
SO - Ann Intern Med 2002 Jun 4;136(11):855-6
UI - 11683331
AU - Furuta Y; Nojima T; Terakura N; Fukuda S; Inuyama Y
TI - A rare case of carcinosarcoma of the maxillary sinus with osteosarcomatous differentiation.
SO - Auris Nasus Larynx 2001 May;28 Suppl():S127-9
AD - Department of Otolaryngology, Hokkaido University School of Medicine, Sapporo, Japan. firstname.lastname@example.org
A unique case of carcinosarcoma in the maxillary sinus is reported. A 47-year-old man visited our hospital with complaints of right nasal obstruction and bloody rhinorrhea. Examination revealed a hemorrhagic mass with necrosis in the maxillary sinus that infiltrated the right nasal cavity. Histologically, the tumor was composed of both carcinomatous and sarcomatous elements. Nests of squamous cell carcinoma and adenocarcinoma were scattered in the sarcomatous element with osteosarcomatous differentiation. No distinct demarcation between the two elements was observed and some spindle-shaped cells in the sarcomatous component were immunoreactive to epithelial markers by immunohistochemical staining. Although the histogenesis of carcinosarcoma remains unclear, the histologic pattern of the present case indicates the possibility that a multipotential cell, capable of both epithelial and mesenchymal differentiation, was the origin of the rare tumor.
UI - 11683349
AU - Yagi K; Fukuda S; Furuta Y; Oridate N; Homma A; Nagahashi T; Inuyama Y
TI - A clinical study on the cervical lymph node metastasis of maxillary sinus carcinoma.
SO - Auris Nasus Larynx 2001 May;28 Suppl():S77-81
AD - Department Otolaryngology, Hokkaido University School of Medicine, Sapporo, Japan. email@example.com
OBJECTIVE: To improve the management of maxillary sinus carcinoma, we retrospectively investigated the significance of cervical lymph node metastasis in our treated cases and discussed how to deal with the cervical lymph node metastasis as a prognostic factor. METHODS: Medical records of 118 patients with maxillary sinus carcinoma diagnosed and treated in our institute from 1982 to 1997 were retrospectively reviewed. Tumors were staged according to UICC classification 1987. The cumulative survival was analyzed by the Kaplan-Meier method. Generally, the patients had undergone preoperative radiotherapy and surgery. We examined the cervical lymph node metastasis detected at the first examination and the subsequent cervical lymph node metastasis in relation to the prognoses. RESULTS: The incidence of cervical lymph node metastasis at the initial diagnosis was 7.9% (n = 9), and that of secondary cervical lymph node metastasis without recurrence at the primary site after the first treatment was 8.3% (n = 9). In most cases, we observed metastasis to the lymph nodes in the submandibular region and in the jugular chain. The result of treatment of cervical lymph node metastasis was grave. Among the patients with cervical lymph node metastasis detected at the first examination, four patients developed local recurrence and three patients developed distant metastasis. On the other hand, among those with secondary cervical metastasis, three patients developed neck recurrence and three patients developed distant metastasis, but no local recurrence. CONCLUSIONS: In the cervical metastasis of maxillary sinus carcinoma, it is important to treat the primary lesion completely. In addition to it. we should control cervical metastasis and careful neck dissection is required. For the patients with cervical lymph node metastasis, it is necessary to consider the further treatment of distant metastasis.
UI - 11893980
AU - Fusconi M; Magliulo G; Della Rocca C; Marcotullio D; Suriano M; de
TI - Vincentiis M Leiomyosarcoma of the sinonasal tract: a case report and literature review.
SO - Am J Otolaryngol 2002 Mar-Apr;23(2):108-11
AD - ENT Department, "La Sapienza" University, Rome, Italy.
Leiomyosarcoma of the paranasal sinuses is uncommon and has an aggressive clinical behavior. Only 28 cases have been described in the literature, and, of these, only 3 patients treated with surgery had a disease-free survival. In this report, we describe the clinical history of a 57-year-old woman with a leiomyosarcoma of the paranasal sinuses successfully treated with a combination of surgery, radiation therapy, and chemotherapy. We obtained a total response with ifosfamide, doxorubicin, dacarbazine, and epirubicin. This case report emphasizes the possibility of treating this aggressive tumor with chemotherapy in accordance with the same therapy used in the treatment of uterine leiomyosarcomas. Copyright 2002, Elsevier Science (USA). All rights reserved.)
UI - 12040661
AU - Yamazaki K; Furuta Y; Marukawa K; Moriya J; Shimizu M; Arakawa M; Itoh
TI - T; Shimizu M; Fukumoto S; Ogura S; Dosaka-Akita H; Nishimura M Inverted papilloma of the nasal cavity presenting with massive amounts of squamous metaplastic cells in sputum. A case report.
SO - Acta Cytol 2002 May-Jun;46(3):596-600
AD - First Department of Medicine, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan.
BACKGROUND: Squamous metaplasic cells are rarely seen in sputum of female nonsmokers. CASE: A 47-year-old female nonsmoker presented with massive amounts of squamous metaplasic cells in sputum and an elevated level of squamous cell carcinoma (SCC) antigen in serum present for months, while no causative lesion was detected either by lung computed tomography or bronchoscopy. The patient was eventually diagnosed as having inverted papilloma in the right nasal cavity. Resection of the tumor brought about disappearance of squamous metaplastic cells in sputum and return of serum SCC antigen to the normal range. CONCLUSION: This case clearly demonstrates that squamous metaplastic cells in sputum can originate in lesions in the nasal cavity, although they are rare. It should be kept in mind that the nasal cavity is a potential site producing squamous metaplastic cells in sputum.
UI - 11444516
AU - Leavitt DD; Watson G; Tobler M; Williams G; Gaffney DK; Shrieve DC
TI - Intensity-modulated radiosurgery/radiotherapy using a micromultileaf collimator.
SO - Med Dosim 2001 Summer;26(2):143-50
AD - Department of Radiation Oncology, University of Utah School of Medicine, Salt Lake City, USA.
Intensity modulation with inverse treatment planning for 3 clinical stereotactic radiotherapy cases were directly compared against forward planning techniques using beam modification by enhanced dynamic wedge. Dose-volume histogram (DVH) analysis demonstrated that a significant reduction in dose to neighboring critical structures can-be achieved through intensity modulation patterns determined from inverse planning, while a marginal change is achieved in the target volume dose uniformity. This study also demonstrates that the intensity modulated dose patterns generated from inverse planning may differ significantly from the intuitive beam modified patterns developed in the forward planning model. These results suggest that one advantage of intensity modulated radiosurgery/radiotherapy with inverse planning is the significant reduction in dose to normal tissue and critical structures, with its coincident implications for dose escalation studies.
UI - 12025763
AU - Schroeder WA Jr; Yingling DG; Horn PC; Stahr WD
TI - Frontal sinus destruction from allergic eosinophilic fungal rhinosinusitis.
SO - Mo Med 2002 May;99(5):197-9
AD - Dept. of Surgery, St. Francis Medical Center, Cape Girardeau.
Extensive fungal infections of the paranasal sinuses are most often associated with immunocompromised patients or poorly controlled diabetics. Seldom do young, otherwise healthy patients present with advanced disease destroying bone and compressing the dura and frontal lobe posteriorly. A case of eosinophilic fungal rhinosinusitis which grew Curvularia lunata in culture is reported. Bone destruction can be common as an expanding inflammatory mass pushes and weakens surrounding bone. The destruction of the frontal sinus with the compression of the dura into the anterior cranial fossa of a 26-year-old requires drainage, reconstruction, and medical management. Our experience with the disease and our approach is reviewed.
UI - 11963189
AU - Richtig E; Regauer S; Jakse R; Anderhuber W; Smolle J
TI - [Primary sinu-nasal melanomas. Clinical aspects, therapy and follow-up]
SO - Hautarzt 2002 Feb;53(2):106-13
AD - Universitatsklinik fur Dermatologie und Venerologie, Abteilung fur Allgemeine Dermatologie, Auenbruggerplatz 8, 8036 Graz, Osterreich.
BACKGROUND AND OBJECTIVE: Primary malignant melanoma of the nasal cavity and paranasal sinuses is a rare entity felt to have a poor prognosis. We examined the frequency and characteristics of this type of melanoma in a defined geographic region over a period of 16 years. PATIENTS/METHODS: Nine patients (eight men, one woman, mean age 62 years) with primary nasal and sinusoidal malignant melanoma were treated between 1985 and 2000 in the Department of Dermatology in cooperation with the Department of Otorhinolaryngology. All patients underwent surgery, eight with clinical complete tumor removal and one with only partial removal. All patients had radiotherapy after surgery. History, potential risk factors, clinical presentation, histological and immunohistochemical data and clinical course were documented. RESULTS: All patients died because of their tumor within the observation period (median survival: 30 months, range 7 to 75 months). There were three different courses of the disease: (1) uncontrollable primary tumor (one patient, survival 11 months); (2) local recurrence with metastasis (five patients, median survival 40.2 months); (3) metastasis after a disease-free interval (three patients, median survival 19.3 months). CONCLUSIONS: Malignant melanoma of the nasal cavity and paranasal sinuses is a rare entity which is usually rapidly fatal. Effective treatment approaches are not available.
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