National Cancer Institute®
Last Modified: June 1, 2002
UI - 11978545
AU - Shintani S; Mihara M; Nakahara Y; Kiyota A; Ueyama Y; Matsumura T; Wong
TI - DT Expression of cell cycle control proteins in normal epithelium, premalignant and malignant lesions of oral cavity.
SO - Oral Oncol 2002 Apr;38(3):235-43
AD - Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine, Ehime, Japan. email@example.com
In this study, we examined the expression of cyclins, cyclin dependent kinase (CDKs) and CDK inhibitors by immunohistochemical analysis in 20 normal mucosa, 42 epithelial dysplasia (ED), and 117 oral squamous cell carcinoma. Neither Cyclin D1 nor CDK2 were detectable in normal tissue and ED. Their presence, however, was detectable in squamous cell carcinoma (SCCs) (Cyclin D1, 35.9%; CDK2, 66.7%). Cyclin E was detectable in 57.1% of severe ED and 62.8% of SCCs. For the CDK inhibitors, these proteins were detectable in all normal mucosa and most of the mild and moderate ED. For severe ED, expression of these proteins was not observed in some cases (p12(DOC-1), 14.3%; p16(INK4A), 28.6%; p27(KIP1), 7.1%). For SCCs, the expression of p12(DOC-1) was lost in 71.8%, p16(INK4A) in 69.2% and p27(KIP1) in 35.9%. These results suggest that elevated expression of cyclin D1, cyclin E, CDK2 and loss of p12(DOC-1), p16(INK4A) and p27(KIP1) may contribute to the multistep nature of oral carcinogenesis.
UI - 11978549
AU - Lin SC; Chen YJ; Kao SY; Hsu MT; Lin CH; Yang SC; Liu TY; Chang KW
TI - Chromosomal changes in betel-associated oral squamous cell carcinomas and their relationship to clinical parameters.
SO - Oral Oncol 2002 Apr;38(3):266-73
AD - Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Li-Nong St. Sec. 2, No. 155 Peitou, Taipei 112, Taiwan.
To investigate the chromosomal imbalances that occur in oral carcinoma associated primarily with betel use and their clinical implications, we performed chromosomal analysis using comparative genomic hybridization on 47 patients with this disease. The most common gains of chromosome arms were 8q, 9q and 11q, and the most frequent losses were of chromosomal arms 3p and 4q. The clinical parameters significantly associated with the numbers of chromosomal imbalances per tumor were the age of the patients and nodal metastasis. The preliminary findings of a lower incidence of loss of 4q and gain of 8q in betel-associated tumors compared to non-betel-associated tumors might provide insight into the carcinogenic effect of betel. Deletion of 3p and the gain of 11q alterations were more prevalent in carcinomas with lymph node metastasis than in node-negative tumors, indicating possible loci for metastasis suppressor or metastasis enhancing genes, respectively. Losses of 3p and 4q and gain of 9q were associated with poor outcome for the patients. These data demonstrated that the frequent aberrations in 4q and 9q sites can be used as novel prognostic predictors.
UI - 11978554
AU - Carlos de Vicente J; Herrero-Zapatero A; Fresno MF; Lopez-Arranz JS
TI - Expression of cyclin D1 and Ki-67 in squamous cell carcinoma of the oral cavity: clinicopathological and prognostic significance.
SO - Oral Oncol 2002 Apr;38(3):301-8
AD - Department of Oral and Maxillofacial Surgery, University Hospital of Oviedo, Oviedo, Spain. firstname.lastname@example.org
The prognostic and clinicopathologic significance of cyclin D1 and Ki-67 expressions was studied in oral squamous cell carcinomas. We performed an immunohistochemical study to determine the level of expression of cyclin D1 and Ki-67 labelling index in tumor specimens obtained from 35 patients, of whom 14 died as a result of recurrent disease, and 20 were free of recurrence at the end of the follow-up period. Overexpression of cyclin D1 was significantly associated with regional lymph node metastases (P=0.00005) and advanced tumor stage (P=0.0007). The relative risk for nodal metastases in the cases that overexpressed cyclin D1 was 2.6. The Ki-67 labelling index was significantly (P=0.001) higher in tumors with poor histologic grade of differentiation. Our results showed that cyclin D1 is a useful prognostic factor, and suggested it could be a marker to help determine the appropriate treatment for patients with oral squamous cell carcinoma. Cyclin D1 and Ki-67 overexpression were positively correlated.
UI - 11978555
AU - Hao SP; Tsang NM
TI - The role of supraomohyoid neck dissection in patients of oral cavity carcinoma(small star, filled).
SO - Oral Oncol 2002 Apr;38(3):309-12
AD - Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taiwan 5 Fu-Hsing Street, Kuei Shan, 333, Taoyuan, Taiwan. email@example.com
The aim of this study was to evaluate the role of supraomohyoid neck dissection (SOHND) in oral carcinoma patients with clinically negative carcinomas and clinically negative lymph nodes in the neck underwent elective SOHND in Chang Gung Memorial Hospital, Taiwan. Thirty-seven patients had postoperative radiotherapy.Thirty-four (24.3%) patients had occult cervical metastases. The overall regional control rates were 93.4% vs. 85.3% for pathologically negative vs positive nodes, respectively, with or without adjuvant radiotherapy. Adjuvant radiotherapy significantly improved ipsilateral regional control (P=0.012) in patients with occult cervical metastases but not in patients with negative neck disease. (P=1.0) SOHND is both a diagnostic and therapeutic procedure in patients with negative neck disease. Its therapeutic role in patients with positive neck disease remains controversial. Postoperative radiotherapy significantly improve ipsilateral neck control in patients with occult cervical metastasis.
UI - 11436896
AU - Lopez de Lacalle JM; Aguirre I; Irizabal JC; Nogues A
TI - Congenital epulis: prenatal diagnosis by ultrasound.
SO - Pediatr Radiol 2001 Jun;31(6):453-4
AD - Department of Radiology, Aranzazu Hospital, Donostia, Spain.
We present a case of congenital epulis, diagnosed prenatally with US. Congenital epulis is a benign gingival tumour whose differential diagnosis includes other oral-facial masses such as haemangioma, granular cell myoblastoma and cystic hygroma. This tumour can cause obstruction of the airway or feeding problems in the newborn child. Surgical excision is the treatment of choice.
UI - 12003583
AU - Browne JD; Holland BW
TI - Combined intraoral and lateral temporal approach for palatal malignancies with temporalis muscle reconstruction.
SO - Arch Otolaryngol Head Neck Surg 2002 May;128(5):531-7
AD - Department of Otolaryngology-Head and Neck Surgery, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1034, USA. firstname.lastname@example.org
OBJECTIVE: To evaluate the use of a combined lateral temporal fossa and intraoral approach to resect palatal carcinomas and the use of a temporalis myofascial flap for reconstruction. DESIGN: Retrospective chart review of a case series. SETTING: Tertiary university referral hospital. PATIENTS: Sixteen patients underwent a combined approach for resection of palatal carcinoma; 5 of the 16 were edentulous. Six types of tumors were treated: adenoid cystic carcinoma (3 patients), low-grade mucoepidermoid carcinoma (5 patients), squamous cell carcinoma (3 patients), polymorphous low-grade adenocarcinoma (2 patients), osteosarcoma (1 patient), ameloblastoma (1 patient), and hyalinizing clear cell carcinoma (1 patient). MAIN OUTCOME MEASURES: The postoperative diet, velum competence, flap viability, complications, and survival. RESULTS: Fifteen (94%) of 16 patients were able to resume their preoperative diets. No velopharyngeal insufficiency was encountered. All flaps survived and none required repeated surgical intervention. Five patients developed serous otitis media and 2 patients required flap revision secondary to posterior choanal obstruction. One patient died of complications unrelated to the procedure. CONCLUSIONS: A combined intraoral and lateral temporal fossa approach allows for (1) en bloc resection of palatal malignancies along with resection of involved pterygoid muscles, (2) isolation and resection of descending palatine nerves and the proximal second division of the trigeminal nerve, and (3) primary reconstruction of the palatal defect by means of the temporalis muscle rotated into the operative defect. This method is especially useful in treating patients with perineural spread of palatal carcinoma, and in those who are edentulous.
UI - 12003599
AU - Wax MK; Bascom DA; Myers LL
TI - Marginal mandibulectomy vs segmental mandibulectomy: indications and controversies.
SO - Arch Otolaryngol Head Neck Surg 2002 May;128(5):600-3
AD - Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, OR 97201, USA. email@example.com
UI - 12003600
AU - Shah JP
TI - The role of marginal mandibulectomy in the surgical management of oral cancer.
SO - Arch Otolaryngol Head Neck Surg 2002 May;128(5):604-5
UI - 12003601
AU - Myers EN; Gastman BR
TI - Clinical commentary on marginal vs segmental resection of the mandible.
SO - Arch Otolaryngol Head Neck Surg 2002 May;128(5):605-6
UI - 11997788
AU - Atik E; Usta U; Aydin NE
TI - Pleomorphic lipoma of the tongue.
SO - Otolaryngol Head Neck Surg 2002 Apr;126(4):430-1
AD - Department of Pathology, Inonu University Medical School, Turkey.
UI - 12017428
AU - Ishii J; Fujita K; Komori T
TI - Clinical assessment of laser monotherapy for squamous cell carcinoma of the mobile tongue.
SO - J Clin Laser Med Surg 2002 Apr;20(2):57-61
AD - Department of Oral and Maxillofacial Surgery, Kobe University School of Medicine, Japan. firstname.lastname@example.org
OBJECTIVE: Laser monotherapy for squamous cell carcinoma of the mobile tongue treated with CO2 laser was carried out on 18 cases between 1979 and 1997. MATERIALS AND METHODS: Three cases recurred after laser surgery. As a subsequent therapy, radiotherapy was performed on two of them and laser surgery was repeated on the remaining one. No recurrences were found in the two patients who died from other diseases after laser surgery. RESULTS: The cure rate of primary tumors was 83.3%. One patient had subsequent metastasis after laser surgery. The rate of recurrence and subsequent metastasis was compared between a group of patients treated with laser surgery and a group treated with radiotherapy (interstitial implant). No differences were found in the rate of recurrence between the two groups. While 22 of 52 patients had a subsequent metastasis in the group treated with interstitial implant, only one patient had it in the group treated with laser surgery. There was a statistical difference between these two groups (p < 0.01).
UI - 11902307
AU - Soni S; Radel E; Smith RV; Edelman M; Sattenberg R; Wadler S; Beitler JJ
TI - Stage 4 squamous cell carcinoma of the tongue in a child: complete response to chemoradiotherapy.
SO - J Pediatr Hematol Oncol 2001 Dec;23(9):612-5
AD - Division of Pediatric Hematology/Oncology, Department of Pediatrics, Montefiore Medical Center, Bronx, New York 10467, USA. email@example.com
This report describes a complete response to a chemoradiotherapy regimen in a child with an advanced and unresectable squamous cell carcinoma of the tongue. An 8-year-old girl had stage 4 squamous cell carcinoma of the tongue (T4N2M0), causing severe trismus and dysphagia. She received hyperfractionated external beam radiotherapy (total 74.4 Gy) and concomitant intravenous infusion of hydroxyurea (0.313 mg/m2 per min) for 43 days. Grade 3 mucositis and myelosuppression were the main toxicities. There was marked symptomatic improvement, and the patient achieved a complete response. She is disease-free 24 months after treatment, and all the acute symptoms have resolved. The regimen was well tolerated with acceptable toxicity and led to a complete objective response. This regimen needs further evaluation to confirm its efficacy and to ascertain its long-term effects in children.
UI - 11965105
AU - Touati S; Boussen H; El Khedim A; Gritli S; Gamoudi A; Benna F; Ben
TI - Abdallah M; El May A; Ladgham A [Cervical lymph node involvement in carcinomas of the mobile tongue in Tunisia. Retrospective study of 135 cases]
SO - Ann Otolaryngol Chir Cervicofac 2002 Feb;119(1):39-43
AD - Service de chirurgie carcinologique cervico-faciale et ORL, Institut Salah Azaiz, Boulevard du 9 avril, Bab Saadoun, Tunis, Tunisie, France.
OBJECTIVE: To report the profile of histologic cervical nodes involvement associated with mobile tongue squamous cell carcinoma. PATIENTS AND METHODS: Our retrospective study concerned patients treated from 1978 to 1998 by cervical neck dissection for mobile tongue carcinoma. RESULTS: A population of 135 patients (90 M/45 F, sex-ratio 2) with a 53.5 mean age (19 to 75) is analyzed. Clinical palpable nodes were present in 68 cases (50%) mainly submental-submaxillar (54). Histologic examination showed a node involvement in 54 cases without (32 cases) or with capsular rupture (22 cases) mainly in the jugulo-carotidian chain (46/54). Among the 67 clinically N0 patients collected after 1990, 22 patients (33%) exhibited an histological involvement vs 32/68 (47%) for the group presenting palpable cervical nodes for the whole period. Histologic node involvement seemed to be linked to the clinical status, node size and TNM stage. CONCLUSION: Cervical lymph node treatment needs to be systematic in mobile tongue carcinoma. The probability of histologic involvement is linked to the loco-regional extent of disease and influences the prognosis. In N0 patients, neck dissection is required because of the frequency of histological involvement, particularly when loss to follow-up may be expected.
UI - 11974076
AU - Kontio R; Salo A; Pitkaranta A
TI - [Radical neck dissection]
SO - Duodecim 1999;115(23):2677-9
AD - HYKS:n leukakirurgian klinikka PL 263, 00029 HYKS. firstname.lastname@example.org
UI - 11857493
AU - Chang KW; Kao SY; Tzeng RJ; Liu CJ; Cheng AJ; Yang SC; Wong YK; Lin SC
TI - Multiple molecular alterations of FHIT in betel-associated oral carcinoma.
SO - J Pathol 2002 Mar;196(3):300-6
AD - Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan, ROC 112.
To determine the alterations of the FHIT (fragile histidine triad) gene in oral squamous cell carcinoma (OSCC), this study examined mutation, promoter methylation, mRNA transcription, and protein expression of FHIT in OSCC associated mostly with the use of betel and/or tobacco. Analyses of the coding exons (exons 5-9) identified a deletion of one base in intron 4 in one tumour and a deletion of exon 7 in two tumours. Using bisulphite genomic sequencing, 28% of the informative subjects exhibited promoter methylation. An aberrant FHIT transcript spanning from exon 3 to exon 10, which was verified by RT-PCR analysis, was identified in 36% of the OSCC subjects, 50% of the oral pre-invasive lesions, and 5% of the non-cancerous match tissue. An abnormal immunohistochemical level of Fhit was detected in 41% of OSCC subjects. A statistically significant association was found between aberrant transcription of the FHIT gene and an abnormal level of Fhit immunoreactivity. The results indicated that alteration of FHIT is a frequent occurrence in OSCC and thus suggests that the aberrance in FHIT transcription could be an early event of oral carcinogenesis. Copyright 2002 John Wiley & Sons, Ltd.
UI - 12014217
AU - Lee HL; Ahn MJ; Choi JH; Jun WH; Lee YY; Kim IS; Choi IY; Jang SJ; Park
TI - YW A case of NK/T-cell lymphoma complicated by a squamous cell carcinoma of hard palate during combination chemotherapy and radiation therapy.
SO - Korean J Intern Med 2002 Mar;17(1):69-72
AD - Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
NK/T-cell lymphoma, which often shows an angiocentric growth pattern, is a distinct clinicopathologic entity highly associated with Epstein-Barr virus. The disease is characterized by a destruction of the upper respiratory tract, particularly the nasal cavity, palate and paranasal sinuses. Interestingly, NK/T-cell lymphoma is closely linked to a variety of complications, such as hemophagocytic syndrome, second primary cancer, sepsis and bleeding. Here we report a case of a 50-year-old man diagnosed initially as NK/T-cell lymphoma of the oropharynx and who developed a second primary carcinoma of the hard palate during combination chemotherapy and radiation therapy.
UI - 11723500
AU - de Carvalho MB; Lenzi J; Lehn CN; Fava AS; Amar A; Kanda JL; Walder F;
TI - Menezes MB; Franzi SA; de Magalhaes MR; Curioni OA; Marcel R; Szeliga S; Sobrinho J; Rapoport A [Clinical and epidemiological characteristics of squamous cell carcinoma of the oral cavity in women]
SO - Rev Assoc Med Bras 2001 Jul-Sep;47(3):208-14
AD - Servico de Cirurgia de Cabeca e Pescoco, Hospital Heliopolis, Sao Paulo, SP.
BACKGROUND: Squamous cell carcinoma (SCC) of the oral cavity occurs mainly in the male population. The objective of the study is to identify the main clinical and epidemiological differences of the oral SCC between men and women. METHODS: Retrospective analysis of the charts of 228 cases of SCC of the oral cavity in women treated at the Head & Neck Surgery Service, Heliopolis Hospital, Sao Paulo, Brazil from 1977 to 1996. The clinical and epidemiological characteristics of these cases were compared with those of 849 male patients. RESULTS: The mean age of women was 60.7 years (ranging 2 to 100 years) and in the male group was 55.6 years (p<0.00001). In cases where the alcohol intake and tobacco use were absent, the tumors ocurred in older patients. The isolated tobacco use didn't affect the distribuction by age but for the alcohol intake (alone or combined with tobacco) the patients were younger. On the alcohol intake, 71% of the women and 8% of the man used no alcohol. The most common sites of tumors were tongue and floor of the mouth but in the women group the incidence of tumors in these sites were 43% compared with 61% in the men. CONCLUSIONS: The highest incidence of SCC the of oral cavity occurs later in women, than in men. This could be explained by a lesser exposure to alcohol and tobacco in women. Other factors seem to be involved in this issue.
UI - 11986779
AU - Gannot G; Gannot I; Vered H; Buchner A; Keisari Y
TI - Increase in immune cell infiltration with progression of oral epithelium from hyperkeratosis to dysplasia and carcinoma.
SO - Br J Cancer 2002 May 6;86(9):1444-8
AD - Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel-Aviv University, Tel Aviv, Israel.
In the present study, epithelium derived lesions of various pathological manifestations were examined histologically and immunohistochemically for mononuclear cell infiltration. The infiltrate under the transformed epithelium of oral lesions, was examined for differences in the composition of immune mononuclear cells as the epithelium moves from hyperkeratosis through various degrees of dysplasia to squamous cell carcinoma. The study was performed on 53 human tongue tissues diagnosed as hyperkeratosis (11 cases), mild dysplasia (nine cases), moderate and severe dysplasia (14 cases) and squamous cell carcinoma (19 cases). A similar analysis was performed on 30 parotid gland tissues diagnosed as pleomorphic adenoma (14 cases) and carcinoma ex-pleomorphic adenoma (16 cases). Immunohistochemical analysis of various surface markers of the tumour infiltrating immune cells was performed and correlated with the transformation level as defined by morphology and the expression of p53 in the epithelium. The results revealed that, in the tongue lesions, the changes in the epithelium from normal appearance to transformed were accompanied by a corresponding increase in the infiltration of CD4, CD8, CD14, CD19+20, and HLA/DR positive cells. The most significant change was an increase in B lymphocytes in tongue lesions, that was in accordance with the transformation level (P<0.001). In the salivary gland, a significant number of cases did not show an infiltrate. In cases where an infiltrate was present, a similar pattern was observed and the more malignant tissues exhibited a higher degree of immune cell infiltration. Copyright 2002 Cancer Research UK
UI - 12006292
AU - Boulos R; Marsot-Dupuch K; De Saint-Maur P; Meyer B; Tran Ba Huy P
TI - Granular cell tumor of the palate: a case report.
SO - AJNR Am J Neuroradiol 2002 May;23(5):850-4
AD - Department of Diagnostic Radiology, Saint-Antoine Hospital, Paris, France.
Granular cell tumor (GCT) is an infrequent benign neoplasm, which Abrikosoff accurately described in 1926. GCT probably has a neural crest cell origin. We present the clinical and imaging findings in a 45-year-old woman with a GCT involving the palate. CT and MR imaging revealed perineural tumor spread along the greater and lesser palatine nerves. We emphasize the peculiarity of the palatine location and the perineural spread of GCTs.
UI - 12030441
AU - Ota Y; Aoki T; Karakida K; Miyasaka M
TI - A case of rupture of the internal jugular vein caused by postoperative infection of functional neck dissection.
SO - Tokai J Exp Clin Med 2001 Dec;26(4-6):123-5
AD - Department of Oral Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan. email@example.com
A 68-year old diabetic man with gingival cancer of the lower jaw underwent resection of the mandible and functional neck dissection. Swabs of a postoperative wound infection revealed methicillin-resistant Staphylococcus aureus (MRSA). The wound was irrigated, and antibiotics administered. The pathogens isolated were sensitive to the antibiotics used, but the infection failed to respond to treatment. Bleeding ensued on the 14th postoperative day (#14POD), when the wound was opened to reveal thrombosis and rupture of the right internal jugular vein. The patient's condition improved after ligation and surgical debridement of the right internal jugular vein. Our experience underlines the importance of early radiological investigation for possible thrombus formation in the internal jugular vein in cases of postoperative wound infection follows functional neck dissection with conservation of the internal jugular vein. It is also important to actively treat this condition surgically, including ligation of internal jugular vein for suppressing inflammation.
UI - 11887444
AU - Badri M; Maartens G; Wood R
TI - Predictors and prognostic value of oral hairy leukoplakia and oral candidiasis in South African HIV-infected patients.
SO - SADJ 2001 Dec;56(12):592-6
AD - Infectious Diseases Unit, Department of Medicine, University of Cape Town.
BACKGROUND: Oral hairy leukoplakia and oral candidiasis diseases (OHL/OC) are common clinical manifestations of HIV/AIDS. Sparse literature exists from resource-limited countries on their incidence and impact on HIV-infected patients. OBJECTIVE: To determine the predictors and prognosis of OHL/OC in HIV-infected patients. METHODS: Patients were drawn from a cohort established in 1992 and prospectively followed until 1997 in the adult HIV clinics, University of Cape Town. Cox hazards regression models were fitted to determine the predictors of OHL/OC, and the association between OHL/OC and progression to AIDS and death. RESULTS: 218 patients presenting with OHL/OC at their initial clinic visit were excluded. 205/772 patients developed OHL/OC (27.8 cases/100 years). White ethnicity (hazard ratio [HR] = 1.73, 95% CI 1.23-2.33), CD4+ count < 200 cells/(L (HR = 2.55, 95% CI 1.89-3.45), total lymphocyte count < 1250 cells/(L (HR = 1.72, 95% CI 1.28-2.31) and WHO stage 3 or 4 (HR = 2.61, 95% CI = 1.93-3.53) where variables predictive of increased hazard to developing OHL/OC. OHL/OC were independently associated with hazard of AIDS (HR = 3.65, 95% CI 1.89-6.69) and death (HR = 2.12, 95% CI 1.47-4.34). CONCLUSIONS: The presence of OHL/OC in HIV-infected patients provides important prognostic information, and can be used as a cost-effective tool for screening patients in therapeutic interventions in resource-limited settings.
UI - 11949802
AU - Flaitz CM
TI - Persistent white lesion of the lateral tongue.
SO - Am J Dent 2001 Dec;14(6):402-3
AD - Department of Stomatology, UT-Houston Dental Branch, TX 77030-3402, USA. Catherine.M.Flaitz@uth.tmc.edu
UI - 12004660
AU - Drinnan AJ
TI - Screening for oral cancer and precancer--a valuable new technique.
SO - Gen Dent 2000 Nov-Dec;48(6):656-60
AD - State University of New York at Buffalo, Department of Oral Diagnostic Sciences, Squire Hall, Room 355, 3435 Main Street, Buffalo, NY 14214-3008, USA.
Many precancerous or cancerous oral lesions may resemble benign lesions and a definitive diagnosis on clinical grounds alone may be difficult, if not impossible, to make. The introduction of OralCDx, an oral brush biopsy procedure, permits the dental practitioner to determine which lesions contain atypical or dysplastic epithelial cells and require that a conventional scalpel biopsy be performed. This article reviews the features of the test, explains the clinical situations for which its use is recommended, and discusses the interpretation and significance of the biopsy reports.
UI - 12004673
AU - Fantasia JE; Damm DD
TI - Mucosal pigmentation. Nevus.
SO - Gen Dent 2001 Jan-Feb;49(1):36, 100
AD - Department of Dental Medicine, Long Island Jewish Medical Center, New Hyde Park, NY, USA.
UI - 12016682
AU - Paparotto Lopes SM; Meeks VI
TI - Analysis of HPV 16 and 18 by in situ hybridization in oral papilloma of HIV+ patients.
SO - Gen Dent 2001 Jul-Aug;49(4):386-9; quiz 390-1
AD - Department of Oral Medicine and Diagnostic Sciences, University of Maryland-Baltimore School of Dentistry, USA.
Human immunodeficiency virus (HIV) infection facilitates the development of other infections and lesions including oral papilloma, which has been associated with human papillomavirus (HPV). In analyzing the presence of HPV 16 and 18 by in situ hybridization in oral papillomas from five HIV+ male dental patients, HPV 16 and 18 were observed in 9 of 16 (52.2%) histopathologic specimens. All positive lesions occurred in heterosexual males admitting to oral sexual contact with a female partner (Pearson's correlation; p = 0.0088). These results suggest that oral sexual behavior may be a contributing factor in the presence of HPV 16 and 18 in oral papilloma.
UI - 11858401
AU - Chang SH; Lee KF; Chan CP; Kuo SB
TI - Myxoma of the gingiva: a case report and literature review.
SO - Chang Gung Med J 2001 Dec;24(12):826-31
AD - Department of Periodontics, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.
Soft tissue myxomas of the oral and para-oral tissue are extremely rare. Only two cases of myxoma of gingiva have been reported in the literature. The histogenesis of these lesions remains obscure. We report a case of gingival myxoma in a 37-year-old man. A firm ovoid soft tissue mass measuring 1.5 x 1.2 x 1 cm in size was noted at the mesio-lingual gingiva of a partially impacted right mandibular third molar. Radiographic examination revealed an impacted mandibular third molar with normal radiographic bony consistency of the mandible. Excisional biopsy was performed with no evidence of recurrence after 8 months. Histological examination showed stromal mass composed of myxoid-like fluid in fibrovascular stroma and scanty inflammatory cell infiltration, suggesting myxomas of the oral soft tissues and jaws. Immunohistochemical stains with S-100 protein, desmin and smooth muscle specific actin yielded negative results, and those with alcian blue, periodic-acid-Schiff, mucicarmine, vimentin and reticulin were positive. Tumor cells of mesenchymal origin without neurogenic or muscular derivations and myxoid matrix composed of acid mucopolysaccharides in this lesion further confirmed the diagnosis of myxoma. Periodontal ligament origin cannot be completely excluded due to tumor location and its association with an impacted molar. However, further study is necessary to clarify the origin and histogenesis of these lesions.
UI - 11992877
AU - Biswas J; Krishnakumar S; Bhavsar K; Shanmugam MP
TI - Choroidal metastasis of a gingival squamous cell carcinoma.
SO - Am J Ophthalmol 2002 May;133(5):713-5
AD - Medical & Vision Research Foundations, Sankara Nethralaya, Chennai, India. firstname.lastname@example.org
PURPOSE: To report a case of choroidal metastasis of a gingival squamous cell carcinoma. DESIGN: Interventional case report. METHODS: Review of the clinical history and pathologic findings. RESULTS: A 59-year-old woman with a history of right gingival squamous cell carcinoma presented with sudden dimness of vision in the left eye of 4 weeks duration. Fundus examination of the left eye revealed a yellowish elevated subretinal lesion involving the optic disk and macula. Fine-needle aspiration biopsy of the choroidal lesion, left eye, revealed metastatic squamous carcinoma cells. The patient was referred to a radiation oncologist for further management. CONCLUSION: Choroidal metastasis from gingival squamous cell carcinoma is rare, and it may develop from hematogeneous spread.
UI - 12015764
AU - Nagpal JK; Mishra R; Das BR
TI - Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis.
SO - Cancer 2002 May 1;94(9):2393-400
AD - Molecular Oncology and Medical Biotechnology Division, Institute of Life Sciences, Chandrasekharpur, Bhubaneswar, India.
BACKGROUND: The Jak/Stat signaling pathway transmits signals from many cytokines and growth factor receptors to target genes in the nucleus. Constitutive activation of Stat-3 recently has been observed in many tumor cells, and dysregulation of the Stat signaling pathway has been proposed to be implicated in malignant transformation. In the current study for the first time to the authors's knowledge, the expression of STAT-3 was analyzed in various stages and sites of squamous cell carcinoma of the head and neck (HNSCC). METHODS: Tissue samples from 90 patients of tobacco chewing-mediated HNSCC representing various stages, sites, and differentiation states were selected for studying STAT-3 protein and RNA expression. In vivo localization of STAT-3 was studied by immunohistochemistry of paraffin embedded sections. The presence of STAT-3 and its phophorylated and activated form pSTAT-3 was checked by Western blotting. mRNA expression was analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR). Apoptosis analysis was conducted by in situ ENA nick end labeling assay and hematoxylin and eosin staining. RESULTS: Overall, 58.9% of HNSCC tumors showed very high Stat-3 protein accumulation, and 23.3% showed intermediate accumulation whereas 17.8% of HNSCC tumors were negative for Stat-3. No Stat-3 was detected in normal samples, and only one of eight premalignant lesions showed intermediate Stat-3 accumulation. On immunoblotting, very high protein accumulation was detected in T1 and T2 classification, moderate in T3 and T4 (P = 0.033, chi-square test), whereas no Stat-3 was detected in normal samples. Similar trend also was found in Stat-3 mRNA expression by RT-PCR analysis which was high in T1 and T2 (early stages), moderate in T3 and T4 (late stages), and no expression in normal samples. The mean apoptotic indices were 1.75, 1.88, and 1.66 for normal, premalignant lesions, and HNSCC cases, respectively. CONCLUSIONS: Stat-3 activation is an early event in head and neck carcinogenesis though its role in blocking the apoptosis in vivo in solid tumors was not observed. Copyright 2002 American Cancer Society.DOI 10.1002/cncr.10499
UI - 12004708
AU - Hsu SD; Singh BB; Lewis JB; Borke JL; Dickinson DP; Drake L; Caughman
TI - GB; Schuster GS Chemoprevention of oral cancer by green tea.
SO - Gen Dent 2002 Mar-Apr;50(2):140-6
AD - Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, USA.
Green tea has been a popular beverage for many centuries. Only recently, however, has the anti-cancer power of green tea constituents been unveiled. Green tea polyphenols are found to induce apoptosis (programmed cell death) in many types of tumor cells, including oral cancer cells. However, mechanisms that enable normal cells to evade the apoptotic effect still are not understood. In this study, cell growth and invasion assays combined with apoptosis assays were used to examine the effects of green tea extracts, green tea polyphenols, and the most potent green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), on normal human keratinocytes and oral carcinoma cells. The results showed that green tea and its constituents selectively induce apoptosis only in oral carcinoma cells, while EGCG was able to inhibit the growth and invasion of oral carcinoma cells. These differential responses to green tea and its constituents between normal and malignant cells were correlated with the induction of p57, a cell cycle regulator. These data suggest that the chemopreventive effects of green tea polyphenols may involve a p57 mediated survival pathway in normal epithelial cells, while oral carcinoma cells undergo an apoptotic pathway. Therefore, regular consumption of green tea could be beneficial in the prevention of oral cancer.
UI - 12023582
AU - Dorji T; Cavazza A; Nappi O; Rosai J
TI - Spitz nevus of the tongue with pseudoepitheliomatous hyperplasia: report of three cases of a pseudomalignant condition.
SO - Am J Surg Pathol 2002 Jun;26(6):774-7
AD - Department of Pathology, University of Bologna Medical School, Italy.
Three cases of Spitz nevus of the tongue associated with pseudoepitheliomatous hyperplasia are reported: two occurring in children and one in an adult. The location at an unusual site and the complex pattern resulting from the intimate admixture of the neoplastic melanocytic component and the hyperplastic keratinocytic component led in each case to consider diagnoses such as malignant melanoma and invasive squamous cell carcinoma. Staining for S-100 protein and keratin was useful to identify and separate the two components. Spitz nevus of the tongue carries some intriguing similarities with granular cell tumor, suggesting a possible histogenetic and pathogenetic relationship.
UI - 11960911
AU - Topcu Z; Chiba I; Fujieda M; Shibata T; Ariyoshi N; Yamazaki H; Sevgican
TI - F; Muthumala M; Kobayashi H; Kamataki T CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka.
SO - Carcinogenesis 2002 Apr;23(4):595-8
AD - Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Department of Oral Patho-biological Science, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-0812, Japan.
We investigated the relationship between inter-individual difference in CYP2A6 genotype and susceptibility to oral cancer among habitual betel quid chewers in a Sri Lanka population. A total of 286 subjects showing oral malignant or premalignant lesions and 135 control subjects with no lesions were analyzed. The frequency of homozygotes for CYP2A6*4C mutation, a gene deletion type of polymorphism, was significantly lower in the case subjects than the controls. The odds ratio (OR) of the group homozygous for the deletion was significantly lower and calculated to be 0.14 (95% CI; 0.03-0.72). In the allelic base analysis, there was also a significant decrease in the OR of the deletion allele. Our data suggest that deficient CYP2A6 activity due to genetic polymorphism reduces oral cancer risk in betel quid chewers.
UI - 11966705
AU - Baykal C; Savci N; Kavak A; Kurul S
TI - Palmoplantar keratoderma and oral leucoplakia with cutaneous horn of the lips.
SO - Br J Dermatol 2002 Apr;146(4):680-3
AD - Department of Dermatology and Oncology Institute, Medical School, Istanbul University, 34390 Istanbul, Turkey. email@example.com
The inherited palmoplantar keratodermas (PPK) may be associated with a wide variety of other ectodermal abnormalities. The coexistence of PPK and leucoplakia may indicate the increased risk of oesophageal carcinoma in adult life. Cutaneous horn may develop over benign, precancerous, as well as malignant lesions, and frequently may be associated with actinic keratoses and Bowen's disease. On the other hand, the relationship of cutaneous horn and leucoplakia has been the subject of only a single case report. We present a case of PPK and diffuse oral leucokeratosis associated with relapsing cutaneous horn of the lips.
UI - 11862197
AU - Lavelle CL
TI - Human papillomavirus.
SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 Feb;93(2):125-6
UI - 11862206
AU - Darling M; Thompson I; Schneider J
TI - Spindle cell lipoma of the alveolar mucosa: a case report.
SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 Feb;93(2):171-3
AD - Division of Oral Pathology, School of Oral Health Sciences, University of Stellenbosch, Tygerberg, South Africa. firstname.lastname@example.org
Spindle cell lipoma of the oral cavity is extremely rare. We report a case occurring on the alveolar mucosa, an oral site that has not been previously reported. A short review of the literature is also presented. The importance of distinguishing this benign lesion from a sarcoma is highlighted. The lesion was excised, and no recurrence has been reported after 2 years.
UI - 12022098
AU - Kurita H; Uehara S; Kojima Y; Kurashina K
TI - Hyoid bone position change after neck dissection for oral cancer: a preliminary report.
SO - J Oral Maxillofac Surg 2002 Jun;60(6):636-41
AD - Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Asahi, Matsumoto, Japan.email@example.com
PURPOSE: The study goal was to evaluate the change in hyoid bone position after neck dissection and tumor resection for oral cancer. PATIENTS AND METHODS: Twenty-seven patients who underwent surgery were retrospectively evaluated. The hyoid bone position was measured before and after the surgery using a topogram of computed tomography scans. RESULTS: There was a statistically significant difference in the hyoid bone position between preoperative and postoperative images in anteroposterior direction (Wilcoxon signed rank test, P <.05), but there was no significant difference in the superoinferior direction. The hyoid bone moved anteriorly when the submandibular region was resected. In cases in which the submental region was resected, it was variably displaced depending on the type of suspension or reconstruction of the resected suprahyoid muscles. CONCLUSION: This limited study suggests that the hyoid bone is displaced after surgery for oral cancer. The hyoid bone was displaced anteriorly if the submandibular region was resected, and it was displaced severely if the submental region was resected. Copyright 2002 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 60:636-641, 2002
UI - 11896817
AU - Weijers M; Snow GB; Bezemer PD; van der Wal JE; van der Waal I
TI - The clinical relevance of epithelial dysplasia in the surgical margins of tongue and floor of mouth squamous cell carcinoma: an analysis of 37 patients.
SO - J Oral Pathol Med 2002 Jan;31(1):11-5
AD - Department of Oral and Maxillofacial Surgery/Pathology, University Hospital Vrije Universiteit/ACTA, Amsterdam, The Netherlands.
BACKGROUND: The clinical relevance of the presence of epithelial dysplasia in the margins of surgically removed oral squamous cell carcinoma is still unclear. METHOD: In a retrospective study, the presence of mild or moderate epithelial dysplasia in the surgical margins of tongue and floor of mouth squamous cell carcinoma was examined histologically. Patients with tumor cells within 0.5 cm of the surgical margins wer