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Abramson Cancer CenterNCI CANCERLIT® Search: Mouth Cancer - July 2002
National Cancer Institute®
Last Modified: July 1, 2002
- [Oral hairy leukoplakia: histopathologic features of subclinical stage]
- Epstein-Barr virus (EBV) subtype in EBV related oral squamous cell carcinoma in Okinawa, a subtropical island in southern Japan, compared
- [Factors affecting local and regional control and survival of carcinomas of the tongue and floor of mouth]
- Clinical function after primary surgery for oral and oropharyngeal cancer: an 11-item examination.
- Health-related quality of life and clinical function after primary surgery for oral cancer.
- Gastro-omental free flaps in oral and oropharyngeal reconstruction:surgical anatomy, complications, outcomes.
- High prevalence of decreased expression of KAI1 metastasis suppressor in human oral carcinogenesis.
- Oral tumours in Tanzanian children based on biopsy materials examined over a 15-year period from 1982 to 1997.
- Congenital epulis: a rare diagnosis in paediatric surgery.
- Benign fibrous histiocytoma (BHF) of the cheek: CD 68-KP1 positivity.
- [A red spot in the mouth floor]
- [Prevention of oral cancer]
- [Second primary tumors following treatment of squamous cell carcinoma of the oral cavity]
- Antioxidant enzyme levels in oral squamous cell carcinoma and normal human oral epithelium.
- Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral squamous cell carcinoma.
- [Lesions of the mouth mucosa. An anamnestic and clinical study of 100 consecutive patients with mucosal lesions]
- Primary malignant melanoma of the oral cavity: case report.
- Chromosome instability in lymphocytes: a potential indicator of predisposition to oral premalignant lesions.
- Treatment of oral cancer: the need for defined protocols and specialist centres. variations in the treatment of oral cancer.
- Deregulated Bag-1 protein expression in human oral squamous cell carcinomas and lymph node metastases.
- [Chemotherapy by superselective intraarterial infusion of nedaplatin combined with radiotherapy for oral cancer]
- [Non-randomized clinical study comparing chemotherapy plus radiotherapy with radiotherapy alone in neoadjuvant therapy for oral cancer]
- [Mouth and throat cancer; new developments]
- [Maxillofacial oncology; quality through cooperation and concentration]
- [Hematology and dentistry. Part V. Clinical manifestations of hematological malignancies in the oral cavity]
- Transforming growth factor beta 1 dysregulation in a human oral carcinoma tumour progression model.
- [Mouth neoplasms: a review]
- [Treatment of mouth cancer. General principles as well as surgical aspects]
- [Treatment of mouth cancer at the end of the nineteenth century]
- The "brush" controversy.
- Significance of p53 expression in non-tumoral epithelium adjacent to oral squamous cell carcinomas.
- Multiple infiltrating lipomas of the tongue.
- Squamous cell carcinoma of the oral mucosa after release of submucous fibrosis and bilateral small radial forearm flap reconstruction.
- Cleft lip and hemangioma.
- Congenital epulis in a neonate.
- [New perspectives for patients with mouth cancer?]
- [Photodynamic therapy of the oral mucosa]
- The role of the dentist in the prevention and early diagnosis of oral cancer.
- Testing your diagnostic skills (#58). Case no. 1. Squamous papilloma.
- Malignant melanoma of mandibular gingiva; the usefulness of fat-saturated MRI.
- Clinical images in oral medicine and maxillofacial radiology. Neurofibromatosis.
- Save a life in 3 minutes.
- Prognostic evaluation of preoperative thermochemoradiotherapy for N(3) cervical lymph node metastases of oral cancer.
- Prognostic significance of apoptosis in squamous cell carcinoma of oral cavity with special reference to TNM stage, histological grade and
- Tenascin and beta 6 integrin are overexpressed in floor of mouth in situ carcinomas and invasive squamous cell carcinomas.
- Views of oral cancer prevention and early detection: Maryland physicians.
- Evaluation of T-classifications of upper gingival and hard palate carcinomas--a proposition for new criterion of T4.
- Oral yeast carriage correlates with presence of oral epithelial dysplasia.
- Importance of tumour thickness measurement in prognosis of tongue cancer.
- Intraduct papilloma of the palate. Report of a case.
- Oral cancer and its detection. History-taking and the diagnostic phase of management.
- Oral cancer campaign.
- Computer-assisted analysis of oral brush biopsies at an oral cancer screening program.
- Oral cancer education.
- Recurrent neck disease in oral cancer.
- Pain, function, and psychologic outcome before, during, and after intraoral tumor resection.
- Lesion of floor of the mouth.
- Peripheral primitive neuroectodermal tumor of the maxillary gingivae with metastasis to cervical lymph nodes: report of a case.
- Recurrence rates in oral cancer.
- [Reconstruction of the anterior floor of the mouth with nasolabial flaps. Report of 10 years' experience]
- [Organization of care for patients with oral mucosal and labial precancer diseases]
- [Combined treatment of patients with oral tumors with extracorporeal neutron-photon therapy]
- [Comparative assessment of 5-year survival with cancer of the buccal mucosa treated by different methods]
- Comment on: S.S. Prime et al. "A review of inherited cancer syndromes and their relevance to oral squamous cell carcinoma" Oral Oncology
- [Smoking and oral diseases]
- Immunohistochemical detection of early-stage carcinogenesis of oral leukoplakia by increased DNA-instability and various malignancy markers.
- Primary gingival leiomyosarcoma. A clinicopathological study of 1 case with prolonged survival.
- Oral cancer among patients under the age of 35 years.
- Improved survival with perilymphatic interleukin 2 in patients with resectable squamous cell carcinoma of the oral cavity and oropharynx.
- Hairy leucoplakia in liver transplant patient.
- Oral hairy leukoplakia.
- Gingival squamous cell carcinoma: a clinical case and differential diagnosis.
- Molecular basis of oral cancer.
- Study comparative of Ki-67 expression in oral lichen planus and oral leukoplakia. Quantitative analysis.
- Melanoma of the oral cavity. Review of the literature.
- [Tumors of the mouth cavity. Not all fluorescent tumors are malignant]
- Multimodal intensification therapy for previously untreated advanced resectable squamous cell carcinoma of the oral cavity, oropharynx, or
- [Incidence of psychopathologic symptoms in patients treated for mouth cancer]
- The role of whole-body FDG-PET in preoperative assessment of tumor staging in oral cancers.
- Solitary fibrous tumour of the mouth: report of two cases involving the tongue and cheek.
- Prevalence of hepatitis virus infection in association with oral diseases requiring surgery.
- Granular congenital cell tumor in the newborn: a case report.
- Squamous cell carcinoma of the oropharynx: surgery, radiation therapy, or both.
- The role of diet and specific micronutrients in the etiology of oral carcinoma.
- Risk factors for oesophageal, lung, oral and laryngeal cancers in black South Africans.
Table of Contents
1
UI - 11705191
AU - Dias EP; Spyrides KS; Silva Junior AS; Rocha ML; da Fonseca EC
TI -
[Oral hairy leukoplakia: histopathologic features of subclinical stage]
SO - Pesqui Odontol Bras 2001 Apr-Jun;15(2):104-11
AD - Departamento de Patologia da Universidade Federal Fluminense.
Oral hairy leukoplakia (OHL) is one of the most common oral
manifestations of AIDS, with diagnostic and prognostic value. OHL is
associated to the Epstein-Barr virus and presents clinical and
histological defined characteristics. There have already been reports
about a subclinical stage of OHL, although they lacked histopathologic
characterization. The present study had the aim to describe the
histopathological characteristics of subclinical hairy leukoplakia, as
well as to carry out a comparative analysis between clinical and
subclinical OHL. For that, 11 cases were analyzed--5 biopsies from
patients who presented with the lesion and 6 samples from the borders of
tongues obtained in necropsies. The histopathological findings in
subclinical OHL were: absence of parakeratosis and papillomatosis, mild
acanthosis, ballooning cells and nuclear alterations. In situ
hybridization and immunostaining were positive for EBV in the nuclear
alterations identified in the histopathological analysis. Based on the
identification of EBV in the nuclear alterations, it was possible to
conclude that subclinical OHL, similarly to the clinical lesion,
presents histopathological features that are specific and sufficient to
establish the definitive diagnosis, regardless of the identification of
the virus.
2
UI - 12037022
AU - Higa M; Kinjo T; Kamiyama K; Iwamasa T; Hamada T; Iyama K
TI -
Epstein-Barr virus (EBV) subtype in EBV related oral squamous cell
carcinoma in Okinawa, a subtropical island in southern Japan, compared
with Kitakyushu and Kumamoto in mainland Japan.
SO - J Clin Pathol 2002 Jun;55(6):414-23
AD - Department of Pathology, Ryukyu University School of Medicine, 207
Uehara, Nishihara, Okinawa 903-0215, Japan. igbucho@jim.u-ryukyu.ac.jp
AIM: In Okinawa, a subtropical island located between the East China Sea
and Pacific Ocean, 2000 km south of mainland Japan, the incidence of
oral squamous cell carcinoma is 1.5 times higher than that seen in
mainland Japan, and a large number of these patients have been reported
to be infected with the Epstein-Barr virus (EBV). This study aimed to
gain a better understanding of the pathogenesis of this malignancy in
this area by carrying out genomic analysis of EBV. METHODS: Fifty four
patients with oral squamous cell carcinoma reported from 1997 to 1999 in
Okinawa were compared with 21 and 20 patients from Kitakyushu and
Kumamoto in Kyushu, mainland Japan, respectively. Diagnosis was
confirmed by conventional histological examination of paraffin wax
sections. EBV was detected by non-isotopic in situ hybridisation (NISH)
and the polymerase chain reaction (PCR) (Bam HI-F, EBV nuclear antigen 2
(EBNA2), and latent membrane protein 1 (LMP-1) regions). Sequence
analysis of the PCR products was also carried out. RESULTS: In Okinawa,
25 patients were found to be infected with EBV type A by analysing the
3' sequence divergence of the EBNA2 genes. Six patients were positive
for EBV type B, and eight for both type A and B. Therefore, type A virus
infection was demonstrated in 33 of 54 patients, and type B in 14 of 54.
In total, 39 of 54 patients were infected with EBV. However, the "f"
variant was shown in only one patient, who was also infected with type A
virus. In contrast, 97.0% of EBV type A infected patients showed a 30 bp
deletion of the LMP-1 gene, but those infected with EBV type B did not.
Sequence analysis of the type A virus EBNA2 gene revealed slight
variations of the sequence (mutations)-(48991)G-->T and (48998)C-->A-in
18 of 33 cases compared with the B95-8 strain, and in 14 cases, in
addition to these, a further mutation of (48917)T-->C was demonstrated;
in the single remaining case, only one mutation at (49137)A-->G was
detected. The mutations at 48991 (G-->T), and 49137 (A-->G) are
associated with amino acid changes Arg-->Met and Thr-->Ala,
respectively. In contrast, no mutation was seen in the EBNA2 DNA from
the 14 cases of type B virus when compared with that of the Jijoye
strain. In Kitakyushu and Kumamoto, only 10 of 41 patients (six in
Kitakyushu and four in Kumamoto) were infected with EBV. Among them,
nine patients were infected with type A virus, and only one patient from
Kitakyushu was infected with type B virus. The (48991)G-->T and
(48998)C-->A mutations of the EBNA2 region were demonstrated in type A
virus, but the (48917)T-->C and (49137)A-->G mutations were not when
compared with the B95-8 strain. In the case of type B virus no mutation
was noted. A 30 bp deletion was found in these nine cases of type A, but
not in type B. The sequence analysis of EBV type A in Okinawa,
Kitakyushu, and Kumamoto showed slight variations when compared with
B95-8, but EBV type B LMP-1 did not when compared with the Jijoye
strains. CONCLUSION: In Okinawa, EBV infection was frequently
demonstrated in oral squamous cell carcinoma (p < 0.001). However, in
mainland Japan there was no significant correlation between EBV and oral
squamous cell carcinoma. In Okinawa, EBV type B infection is
approximately 10 times more common than in the mainland. However, in
these areas-Okinawa, Kitakyushu, and Kumamoto-the frequency of the "f "
variant was very low, whereas a high incidence of a 30 bp deletion of
LMP-1 was noted. The number of EBV (including type A and/or B) infected
oral squamous cell carcinomas in Okinawa was about three times higher
than that seen in the mainland, although the frequency of oral squamous
carcinoma was only 1.5 times higher than that seen in the mainland. A
high prevalence of type B virus infection and slight differences in the
EBNA2 gene sequence in the type A virus might influence the frequency of
this carcinoma in Okinawa.
3
UI - 11998516
AU - Herranz Gonzalez-Botas J; Vazquez Barro C; Lopez Amado M; Martinez Moran
TI -
A; Chao Vieites J
[Factors affecting local and regional control and survival of carcinomas
of the tongue and floor of mouth]
SO - Acta Otorrinolaringol Esp 2002 Jan;53(1):32-8
AD - Servicio de Otorrinolaringologia, Hospital Juan Canalejo, La Coruna.
A retrospective study of 142 patients that had previous surgery for
carcinoma of the tongue or floor of mouth looking into the factors that
affect significantly the evolution of our patients and in which
circumstances we could benefit from new therapeutic techniques. Cause
specific survival at 3 and 5 years was 63.4% and 56.9% respectively.
Recurrences were found locally in 32 patients (22.5%), regional in 32
(22.5%) and metastasis in 11 (7.4%). T staging had no did impact on
local recurrence, but the presence of positive margins (p = 0.0323).
Regional control for N0/N1 was 85% (90/106) versus 55.5% (20/36) for
N2/N3 (p = 0.001). Regional control by N staging was 84.5% (73/86) for
N0, 85% (17/20) for N1, 57% (30/35) for N2 and 0% for N3 (0/1). Both, N
staging and number of positive nodes had a significant impact in
specific survival. Positive margins and the presence of positive nodes
have the greatest impact on survival and regional control. Adjuvant
postoperative radiotherapy did not increase survival, but not
prospective random selection was performed. To evaluate this.
4
UI - 11883962
AU - Rogers SN; Lowe D; Patel M; Brown JS; Vaughan ED
TI -
Clinical function after primary surgery for oral and oropharyngeal
cancer: an 11-item examination.
SO - Br J Oral Maxillofac Surg 2002 Feb;40(1):1-10
AD - Regional Maxillofacial Unit, University Hospital Aintree, Aintree Trust,
Liverpool, UK. snrogers@globalnet.co.uk
The aim of this study was to record clinical function using an 11-item
clinical examination and identify the main postoperative functional
deficits.Of 132 consecutive patients undergoing surgery for previously
in the study. An 11-domain clinical examination was made on the day
before operation, and at 6 and 12 months afterwards. This examination
assessed lip competence, tongue movement, oral mucosa, dental state,
mouth opening, speech, drooling, diet, appearance, oral sensation and
shoulder movement.Preoperatively there were deficits in natural
dentition, consistency of diet and tongue protrusion. Postoperatively
functional scores fell particularly for tongue movements, mouth opening,
mucosa, dentition, speech, diet, appearance, lip sensation and tongue
sensation. At 1 year, dental status, sensation and oral mucosa were
particularly defective. Patients with large tumours, free tissue
transfer, or adjuvant radiotherapy had the worst levels of function.A
simple clinical examination provides a rapid assessment of function that
can be used in conjunction with validated questionnaires to provide a
more comprehensive evaluation of outcome. Copyright 2002 The British
Association of Oral and Maxillofacial Surgeons.
5
UI - 11883963
AU - Rogers SN; Lowe D; Fisher SE; Brown JS; Vaughan ED
TI -
Health-related quality of life and clinical function after primary
surgery for oral cancer.
SO - Br J Oral Maxillofac Surg 2002 Feb;40(1):11-8
AD - Regional Maxillofacial Unit, University Hospital Aintree, Aintree Trust,
Liverpool, UK. snrogers@globalnet.co.uk
Clinical function and health-related quality of life (HRQoL) are both
important outcome parameters following surgery for oral and
oropharyngeal cancer. The aim of this project was to explore the
relationship between an 11-point clinical examination and HRQoL. Of 132
consecutive patients undergoing surgery for previously untreated disease
The University of Washington Quality of Life Questionnaire (UW-QoL) was
completed by each patient on the day before operation and 6 and 12
months later. On each occasion the first author made an 11-point
clinical examination. The main predictors of cumulative UW-QoL scores
were tumour size, clinical functional score and type of operation. The
trend was for a fall from preoperative levels at 6 months and then for a
slight improvement at 1 year. The differential in respect of baseline
function was present at all three time points in each patient group.
This suggests that functional deficits at presentation persist following
treatment. Copyright 2002 The British Association of Oral and
Maxillofacial Surgeons.
6
UI - 11883967
AU - Gallagher J; Webb A; Ilankovan V
TI -
Gastro-omental free flaps in oral and oropharyngeal
reconstruction:surgical anatomy, complications, outcomes.
SO - Br J Oral Maxillofac Surg 2002 Feb;40(1):32-6
AD - Department of Oral and Maxillofacial Surgery, Poole Hospital, Poole, UK.
j.gallagher@cwcom.net
Free gastro-omental flaps can be used to reconstruct defects in the oral
cavity after ablative cancer surgery. The omentum can provide as much
bulk as required. The generous gastro-omental pedicle allows mobility.
The gastric mucosal lining has the advantage that it produces mucus,
does not carry hair follicles and is not prone to troublesome
desquamation. This paper reviews the surgical anatomy of free
gastro-omental flaps and presents a series of eight cases in which these
flaps were used for oral and oropharyngeal reconstruction. Copyright
2002 The British Association of Oral and Maxillofacial Surgeons.
7
UI - 11895916
AU - Uzawa K; Ono K; Suzuki H; Tanaka C; Yakushiji T; Yamamoto N; Yokoe H;
TI -
Tanzawa H
High prevalence of decreased expression of KAI1 metastasis suppressor in
human oral carcinogenesis.
SO - Clin Cancer Res 2002 Mar;8(3):828-35
AD - Department of Clinical Molecular Biology, Graduate School of Medicine,
Chiba University, Chiba 260-8670, Japan.
PURPOSE: KAI1 was originally identified in prostate cancer as a
metastasis suppressor gene. Recent studies have shown a frequent
down-regulation of KAI1 expression in many tumor types, whereas mutation
or hypermethylation of the gene is infrequent. The aim of the present
study was to examine whether loss of KAI1 expression that might be
caused by genetic or epigenetic alterations could contribute to oral
carcinogenesis. EXPERIMENTAL DESIGN : We analyzed mutational and
methylation status of the KAI1 gene and both the mRNA and protein level
in a series of oral tumors [28 precancerous lesions, 101 primary oral
squamous cell carcinomas (OSCCs), and 30 metastatic OSCCs] and
OSCC-derived cell lines. We also examined p53 protein expression, which
has been reported to be a candidate activator for the KAI1 gene.
RESULTS: With the exception of three microsatellite instabilities in the
KAI1 gene, we found no mutations in the coding sequence of the KAI1
gene, no loss of heterozygosity, and no hypermethylation of the KAI1
promoter region in all samples investigated. By immunohistochemistry,
however, high frequencies of KAI1 down-regulation were evident not only
in the metastatic OSCCs [29 of 30 (97%)] but also in the primary OSCCs
[83 of 101 (82%)] and in the precancerous lesions [13 of 28 (46%)].
There was a significant relationship between down-regulation of KAI1
protein expression and primary tumors associated with lymph node
metastases (P = 0.0115), whereas there was no statistical correlation
between p53 status and KAI1 expression. Taken together, reverse
transcription-PCR data were consistent with the protein expression
status in 16 patients from whom mRNA was available. CONCLUSIONS: Our
data suggest that whereas loss of KAI1 protein expression is associated
with primary tumors with lymph node metastases, the down-regulation of
KAI1 is an early event in the progression of human oral cancer. The
down-regulation of KAI1 is not associated with either mutation, allelic
loss, methylation of the promoter, or p53 regulation.
8
UI - 11933896
AU - Kalyanyama BM; Matee MI; Vuhahula E
TI -
Oral tumours in Tanzanian children based on biopsy materials examined
over a 15-year period from 1982 to 1997.
SO - Int Dent J 2002 Feb;52(1):10-4
AD - Department of Oral Surgery & Oral Pathology, Faculty of Dentistry,
Muhimbili University College of Health Sciences, Dar es Salaam,
Tanzania.
AIM: To provide information on the types and distribution of oral
tumours and tumour-like lesions occurring in a Tanzanian child
population aged 0-16 years. DESIGN: Retrospective study of biopsy
results from hospital records from 1982-1997. SETTING: Department of
Histopathology, the Muhimbili Medical Centre (MMC) in Dar es Salaam.
INTERVENTION/ METHODS: A total of 158 biopsy results, from 75 girls and
83 boys, were retrieved and studied. RESULTS: Malignant tumours were the
most frequent (43.0%) followed by benign tumours (30.4%) and tumour-like
lesions (26.6%). Burkitt's lymphoma was the most frequent malignant
tumour accounting for 88.2% of all malignancies followed by squamous
cell carcinoma (4.4%) and oral Kaposi's sarcoma (2.9%). Fibroma,
papilloma and haemangioma were the most frequent benign tumours
constituting 27.1%, 14.6% and 12.5%, respectively. Odontogenic cysts
were the most frequent tumour-like lesions (28.6%) followed by fibrous
dysplasia (19%) and giant cell granuloma (16.7%). CONCLUSION: The six
most common oral lesions were Burkitt's lymphoma, fibroma, odontogenic
cysts, fibrous dysplasia, papilloma and giant cell granuloma.
9
UI - 12015658
AU - Reinshagen K; Wessel LM; Roth H; Waag KL
TI -
Congenital epulis: a rare diagnosis in paediatric surgery.
SO - Eur J Pediatr Surg 2002 Apr;12(2):124-6
AD - Abteilung fur Kinderchirurgie, Chirurgische Klinik der
Ruprecht-Karls-Universitat Heidelberg, Heidelberg, Germany.
Konrad_Reinshagen@med.uni-heidelberg.de
Congenital epulis of the newborn is a rare tumour which is usually
benign. The first description of a case is attributed to Neumann in
1871. The word "epulis" is derived from Greek and means "on the gum" or
"gum boil". Epulis is also known as a congenital gingival granular cell
tumour because of its histological features. Since 1871, 216 cases have
been reported. Female babies are affected 8-10 times more often than
males. Epulis is located on the maxillary ridge twice as often as on the
mandible, mostly as single tumours but rarely as multiple tumours.
Macroscopically, epulis is a pedunculated tumour with a smooth or
lobulated surface. The basis of the tumour is the alveolar mucosa. The
size varies from a few millimetres to 9 cm in diameter. After birth, the
tumour normally does not increase in size. Microscopic examination shows
a central mass of granular cells. This mass is surrounded by a
stratified squamous mucosa. The histogenesis of the tumour is unknown.
Spontaneous regression of congenital epulis has been reported in four
cases. However, surgical excision is generally indicated due to
interference with feeding or respiration. Recurrence of the tumour after
surgery has not been reported yet.
10
UI - 11590079
AU - Femiano F; Scully C; Laino G; Battista G
TI -
Benign fibrous histiocytoma (BHF) of the cheek: CD 68-KP1 positivity.
SO - Oral Oncol 2001 Dec;37(8):673-5
AD - Stomatology Clinic. II, University of Medicine and Surgery, Napoli,
Italy. femiano@libero.it
We present a case of fibrous histiocytoma of the cheek in a 32-year-old
male with no evidence of any regional invasion or distant metastasis.
Pathologic analysis and diagnosis of these lesions is often challenging,
and usually based on a combination of light microscopy and
immunohistochemistry. In this study the diagnosis was confirmed using
immunostaining with the antibody CD 68-KP1 that is positive in any
lesion containing lysosomal granules or phagolysosomes.
11
UI - 11830994
AU - van der Waal I
TI -
[A red spot in the mouth floor]
SO - Ned Tijdschr Tandheelkd 1994 Feb;101(2):66
12
UI - 11830977
AU - Roodenburg JL; Vermey A; Nauta JM
TI -
[Prevention of oral cancer]
SO - Ned Tijdschr Tandheelkd 1994 May;101(5):200-3
AD - Afdeling Mondziekten, Kaakchirurgie en Bijzondere Tandheelkunde,
Academisch Ziekenhuis Groningen, postbus 30.001, 9700 RB Groningen.
Etiology control is the most important primary prevention of oral
cancer. The use of tobacco and alcohol increases the risk of a squamous
cell carcinoma of the oral mucosa. The dentist can play an important
role in the secondary prevention or screening for premalignant lesions,
asymptomatic malignancies and second primary tumours of the oral cavity.
Because of their age, edentulous patients run a high risk of oral
cancer. Therefore, a regular oral check-up of these patients should be
recommended.
13
UI - 11831177
AU - van der Tol IG; Jovanovic A; Schulten EA; Kostense PJ; de Vries N; Snow
TI -
GB; van der Waal I
[Second primary tumors following treatment of squamous cell carcinoma of
the oral cavity]
SO - Ned Tijdschr Tandheelkd 1994 Oct;101(10):403-5
AD - Afdeling Mondziekten en Kaakchirurgie en Orale Pathologie, Academisch
Ziekenuis Vrije Universiteit/Academisch Centrum voor Tandheelkunde
Amsterdam (ACTA).
In the hospital of the Free University in Amsterdam (the Netherlands)
727 patients with primary squamous cell carcinoma of the oral cavity and
lip have been studied for the incidence of second primary tumors
occurring in the respiratory and upper digestive tract. Out of the 727
patients, 74 (10.2%) developed a second primary tumor in these tracts.
The incidence of second primary tumors was expressed per 1.000
person-years of follow-up; 28 second primary tumors per 1.000
person-years of follow-up were seen in the respiratory and upper
digestive tract. The patients ran the risk of developing a second
primary tumor at a steady rate of approximately 2.8% per year during at
least ten years. Furthermore, an increasing incidence of second primary
tumors could be observed in case of increasing use of tobacco.
14
UI - 11896826
AU - Yang J; Lam EW; Hammad HM; Oberley TD; Oberley LW
TI -
Antioxidant enzyme levels in oral squamous cell carcinoma and normal
human oral epithelium.
SO - J Oral Pathol Med 2002 Feb;31(2):71-7
AD - Department of Oral Medicine, Temple University School of Dentistry,
Philadelphia, PA 19140, USA. jyang@dental.temple.edu
BACKGROUND: The antioxidant enzymes (manganese- and
copper-zinc-containing superoxide dismutases, catalase and glutathione
peroxidase) limit cell injury induced by reactive oxygen species. The
purpose of the study was to determine whether human oral squamous cell
carcinomas have altered antioxidant enzyme levels. This study is the
first to undertake this task in human oral mucosa and squamous cell
carcinoma. METHODS: Semiquantitative immunohistochemistry was used to
examine 26 archived oral squamous cell carcinoma biopsies. Fourteen
well-differentiated and 12 poorly differentiated tumors were examined,
as were 12 specimens of oral mucosa. All sections were reviewed by two
oral and maxillofacial pathologists, and image analysis of the
immunostained sections was performed using NIH Image. Antioxidant enzyme
staining intensities were compared in the different groups by Duncan's
multiple range test. RESULTS: In general, mucosal basal cells displayed
lower antioxidant enzyme levels than spinous cells, and primary tumor
cells displayed lower antioxidant enzyme staining intensities than did
their normal cell counterparts. Moreover, poorly differentiated tumor
cells showed lower antioxidant enzyme staining intensities than
well-differentiated tumor cells. Manganese-containing superoxide
dismutase staining intensities were, however, higher in
well-differentiated oral squamous cell carcinomas than their normal
cells of origin. CONCLUSIONS: Detection of antioxidant enzymes may be a
useful future marker in the molecular diagnosis of the oral cancer.
Moreover, it may be possible to not only monitor the effectiveness of
chemopreventive and therapeutic strategies in oral cancer using these
enzymes, but to monitor tumor recurrence.
15
UI - 11896827
AU - de Sousa SO; Mesquita RA; Pinto DS Jr; Gutkind S
TI -
Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral
squamous cell carcinoma.
SO - J Oral Pathol Med 2002 Feb;31(2):78-81
AD - Department of Oral Pathology, University of Sao Paulo, School of
Dentistry, Sao Paulo, Brazil.
BACKGROUND: Studies have addressed the relevance of c-Jun and c-Fos
proteins in cancer development. In the present study, the expression of
c-Jun and c-Fos, the major components of transcription factor activator
protein (AP1), were evaluated to determine possible alterations to these
factors in oral squamous cell carcinoma (OSCC). METHODS: Fifteen cases
of normal oral mucosa and 20 cases of OSCC were retrieved from the
Archives of the Surgical Pathology Service at the University of Sao
Paulo. The samples of normal oral mucosa or OSCC originated from
different oral mucosal sites. Tissues were submitted for
immunohistochemical analysis to detect c-Jun and c-Fos proteins. The
OSCC was classified as well, intermediate or poorly differentiated.
RESULTS: The results showed that both c-Jun and c-Fos are expressed in
normal oral mucosa and in OSCC. In normal mucosa, immunoreactivity for
c-Jun was detected in the cytoplasm of the upper basal layers, while in
OSCC, c-Jun was detected in the nuclei of the cells. C-Fos expression
was observed in the nuclei of cells, both in normal mucosa and in OSCC,
but its expression varied according to the cell layer in normal mucosa,
and the differentiation of OSCC. CONCLUSIONS: The nuclear expression of
c-Jun in OSCC, in contrast to its cytoplasmic expression in normal oral
mucosa, indicates that c-Jun may have a role in the development of oral
cancer. In contrast, the absence of both c-Jun and c-Fos in poorly
differentiated carcinoma might be useful in understanding the cell cycle
events important in uncontrolled cell growth.
16
UI - 12092562
AU - von Arx T; Koch S; Hardt N
TI -
[Lesions of the mouth mucosa. An anamnestic and clinical study of 100
consecutive patients with mucosal lesions]
SO - Schweiz Monatsschr Zahnmed 2002;112(4):326-9
AD - Klinik fur Oralchirurgie und Stomatologie, Universitat Bern
The present study evaluates and analyzes anamnestic and clinical
findings of 100 consecutively referred patients with oral mucosal
lesions. The mean age of the cohort was 50.5 years (range 8-91 years)
with a female rate of 60 percent. A total of 9 malignant neoplasia were
found among the 100 mucosal lesions, including 7 squamous cell
carcinomas and 2 mucoepidermoid carcinomas. In addition, 11 cases
presented with leukoplakia and 4 cases with lichen planus, both
recognized as possible precancerous conditions. These figures support
the essential role of the dentist with respect to initial diagnosis and
prevention of oral cancer. In addition, stomatologic follow-up
examinations are recommended to be performed by each and every general
practitioner. In the near future, the dentist will assess oral mucosal
lesions more frequently due to the increasing number of elderly patients
and to the fact that elderly people present with more lesions compared
to younger patients. consistent to literature data, patients with
leukoplasia and squamous cell carcinoma had the highest rates of tobacco
and alcohol consumption. Therefore, the dentist may also become active
in giving preventive information to the patient. the results of the
present study showed, that--by employing a standardized examination--a
correct clinical diagnosis was identical to the final diagnosis
established by laboratory techniques.
17
UI - 12010347
AU - Bongiorno MR; Arico M
TI -
Primary malignant melanoma of the oral cavity: case report.
SO - Int J Dermatol 2002 Mar;41(3):178-81
AD - Department of Dermatology, University of Palermo, Via del Vespro 131,
90123 Palermo, Italy. ISTDERM@UNIPA.IT
An 80-year-old-female patient had a pigmented lesion on: the hard
palate, the soft palate, the alveolar mucosa and the vestibular mucosa
of the maxillary gingiva. Pigmented macules and patches had been
persistent and asymptomatic for many years (Fig. 1). The lesion
exhibited irregularities of pigmentation, border and surface contour.
About 1 year later the patient had noticed an extension of the pigmented
macules and plaques; there was also the appearance of nodules of the
maxillary gingiva accompanied by swelling. Loosening of teeth as a
result of extensive destruction of bone was further noted (Fig. 2). The
histological examination showed a downward streaming in the dermis of
the tumor cells and a disintegration and ulceration of the epidermis
(Fig. 3). An increased number of large round or polygonal cells
resembling atypical epithelioid cells were found on the submucosa. The
atypical cells had enlarged, pleomorphic nuclei with prominent and
sometimes multiple nucleoli. Mitoses were observed at various tissue
levels (Fig. 4). Abundant pigmented melanin was present in the tumor
cells (Fig. 5). Many cells had fine, dusty melanin particles. The tumor
cells showed great variations in size. Immunohistochemical staining,
with S100 protein and HMB45 antibodies, stained many of the
spindleshaped cells, indicating that they were melanocytic cells. An
inflammatory infiltrate of lymphocytes was seen in a band beneath the
invading tumor cells.
18
UI - 12019158
AU - Wu X; Lippman SM; Lee JJ; Zhu Y; Wei QV; Thomas M; Hong WK; Spitz MR
TI -
Chromosome instability in lymphocytes: a potential indicator of
predisposition to oral premalignant lesions.
SO - Cancer Res 2002 May 15;62(10):2813-8
AD - Department of Epidemiology, The University of Texas M. D. Anderson
Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
xwu@mail.mdanderson.org
Oral premalignant lesions (OPLs) are related to tobacco use and mark
individuals at high risk for oral cancer development. Increased mutagen
sensitivity as measured by an in vitro mutagen challenge assay has been
shown to be a risk factor for upper aerodigestive tract cancers. In this
case control study, we used two assays with mutagens relevant to tobacco
exposure (benzo[a]pyrene diol epoxide (BPDE) and bleomycin) to see
whether sensitivity to these mutagens could be used as biomarkers for
assessing risk of premalignant lesions. Furthermore, we evaluated
whether 3p21.3 is a molecular target of BPDE damage in lymphocytes of
patients with OPLs. There were 82 patients with OPLs and 89 healthy
controls frequency matched to the cases on age, sex, ethnicity, and
smoking status. These subjects' lymphocytes were treated in two separate
experiments with either 2 microM BPDE for 24 h or 0.03 units/ml
bleomycin for 5 h, and the frequency of induced chromatid breakage in
Giemsa-stained preparations was determined. BPDE-induced 3p21.3
aberrations were scored by fluorescent in situ hybridization technique
in 1000 interphases/sample. We found that the mean BPDE-induced
chromatid breaks per cell were higher in cases than controls (1.05 +/-
0.40 and 0.55 +/- 0.27, respectively; P < 0.01). Similar results were
evident with bleomycin-induced chromatid breaks per cell (0.78 +/- 0.37
and 0.57 +/- 0.31, respectively; P < 0.01). After adjusting for age,
sex, ethnicity, and smoking status, significantly elevated odds ratios
(95% confidence interval) for OPL risk were noted for BPDE sensitivity
[12.96 (5.51, 30.46)] and bleomycin sensitivity [3.33 (1.64, 6.77)].
When subjects were categorized into quartiles of the number of breaks
per cell, a dose response was observed for both assays. The adjusted
odds ratios for subjects with increasing numbers of breaks per cell in
quartiles were 2.34, 9.14, and 54.04 for BPDE sensitivity and 1.92,
3.33, and 7.15 for bleomycin sensitivity, respectively. Subjects
sensitive to both mutagens had a 50-fold increased risk for OPLs. In
addition, there were significantly more BPDE-induced chromosome
aberrations at the 3p21.3 locus in cases (51.13/1000) than in controls
(40.93/1000; P < 0.0001). However, no such difference was observed for
3q13, a control locus. BPDE-induced 3p21.3 aberrations were associated
with an elevated risk for OPLs of 6.08 (2.57, 14.4). The degree of BPDE
sensitivity at 3p21.3 and risk for OPLs increased in a dose-dependent
manner. In summary, BDPE sensitivity and bleomycin sensitivity appear to
be individually and jointly associated with elevated risk of OPLs.
Furthermore, 3p21.3 may be a molecular target of BPDE in OPLs. This is
the first study to examine mutagen sensitivity in a premalignant
condition. The next step is to correlate these findings in surrogate
(lymphocyte) tissue with molecular events in the target tissue.
19
UI - 11824876
AU - Robertson AG; Robertson C; Soutar DS; Burns H; Hole D; McCarron P
TI -
Treatment of oral cancer: the need for defined protocols and specialist
centres. variations in the treatment of oral cancer.
SO - Clin Oncol (R Coll Radiol) 2001;13(6):409-15
AD - Beatson Oncology Centre, Western Infirmary, Glasgow, UK.
The authors of this study aimed to identify treatment philosophies for
oral cancer within the west of Scotland and to investigate any survival
differences associated with the various treatment options by means of a
retrospective review of case notes and cancer registry data. All
patients with squamous cancer of the tongue or floor of the mouth were
identified from the West of Scotland Cancer Registry for the period
1984-1990. A total of 206 patients were available for study. Five
different treatment protocols were identified: 5% of patients underwent
biopsy only, 16% biopsy plus radiotherapy, 11% excisional biopsy, 25%
radical surgery, and 42% radical surgery plus radiotherapy. Tumour
staging by the TNM classification was an important factor that
determined outcome. When adjusting for T stage and nodal involvement,
there was a significant effect of treatment protocol on both the
disease-free period (P < 0.001) and on survival (P < 0.001). The
treatment options were used differently by individual clinicians and
were related to stage of the disease. One hundred and forty-four (70%)
of the patients were treated by a single combined head and neck unit
based within the plastic surgery unit at Canniesburn Hospital. The
remaining 62 were treated in 13 different units throughout the west of
Scotland. For those not treated in the combined head and neck unit, the
increased hazard for recurrence was 1.43 (95% confidence interval (CI)
1.01-2.02), and the increased hazard ratio for death was 1.48 (95% CI
1.06-2.06) when adjusting for tumour stage, and nodal involvement.
Treatment philosophies for oral cancer have a significant effect on
outcome. There is a need to develop clearly defined protocols based on
staging and site of disease. We believe that treatment should be carried
out within a multidisciplinary setting in a combined head and neck
cancer unit.
20
UI - 12081206
AU - Hague A; Packham G; Huntley S; Shefford K; Eveson JW
TI -
Deregulated Bag-1 protein expression in human oral squamous cell
carcinomas and lymph node metastases.
SO - J Pathol 2002 May;197(1):60-71
AD - Department of Oral and Dental Science, University of Bristol, Bristol
Dental Hospital and School, UK. a.hague@bristol.ac.uk
Bag-1 is an anti-apoptotic protein that promotes metastasis in some
tumour cell types. To determine whether Bag-1 expression is altered in
64 oral squamous cell carcinomas, tumour samples were compared with 17
samples of normal oral epithelium. Normal oral epithelia had pronounced
nuclear staining in the basal and maturation layers and weak cytoplasmic
staining that was most pronounced in the basal and suprabasal layers.
Oral squamous cell carcinomas demonstrated a tendency for reduced
nuclear staining intensity (p=0.036). Cytoplasmic staining intensity was
not significantly different between tumour and normal tissue. However,
many tumours were observed to have less of a difference between nuclear
staining intensity and cytoplasmic staining intensity than normal oral
epithelium. Furthermore, in lymph node metastases, cytoplasmic Bag-1
staining was stronger in 8/13 cases than in corresponding primary
tumours (p=0.021). Western blotting using nine oral primary carcinoma
cell lines and four normal keratinocyte cultures showed that the
isoforms Bag-1s, Bag-1M, and Bag-1L were expressed in normal and
malignant oral epithelial cells. Bag-1L unique sequences were shown to
adopt an exclusively nuclear, and predominantly nucleolar, localization
by use of transiently transfected N-terminal Bag-1L-EGFP. However,
levels of Bag-1L in carcinoma cells did not differ significantly from
those of normal keratinocytes. Therefore the reduced nuclear staining
observed in oral squamous cell carcinomas compared with normal
epithelium may reflect changes in the localization of Bag-1 isoforms,
rather than decreased expression of Bag-1L. Alterations in the relative
proportions of Bag-1S, Bag-1M, and Bag-1L were detected in 6/9 oral
carcinoma cell lines; 5/9 oral carcinoma cell lines had a significantly
greater proportion of Bag-1M than normal keratinocytes and in another
cell line, Bag-1L was significantly underrepresented. Overall, the
results suggest that Bag-1 deregulation plays a role in oral
carcinogenesis at two different stages: during primary carcinoma
development and during lymph node metastasis.
21
UI - 12090042
AU - Yamashita Y; Goto M; Katsuki T
TI -
[Chemotherapy by superselective intraarterial infusion of nedaplatin
combined with radiotherapy for oral cancer]
SO - Gan To Kagaku Ryoho 2002 Jun;29(6):905-9
AD - Dept. of Oral and Maxillofacial Surgery, Saga Medical School.
Nedaplatin (CDGP), which is a CDDP derivative, has been reported to be
an effective anticancer agent for head and neck cancer. This study was
performed to assess the feasibility of chemotherapy by superselective
intraarterial infusion of nedaplatin (CDGP) in patients with oral
cancers. Ten patients were treated with chemotherapy by superselective
intraarterial infusion of CDGP combined with radiotherapy. The complete
and partial response rates were 7/10 (70%) and 3/10 (30%), respectively.
Nine patients showed grade 1-2 hematological toxicity including
leukocytopenia and anemia. Thrombocytopenia of grade 4 was seen in only
one patient. However, all the patients were free from renal dysfunction.
From these results, it is suggested that this combination therapy might
be quite effective and safe. Further study will be needed to determine
its efficacy against oral cancer.
22
UI - 12090043
AU - Kayahara H; Okuda M; Terakado N; Shintani S; Hamakawa H
TI -
[Non-randomized clinical study comparing chemotherapy plus radiotherapy
with radiotherapy alone in neoadjuvant therapy for oral cancer]
SO - Gan To Kagaku Ryoho 2002 Jun;29(6):911-6
AD - Dept. of Oral and Maxillofacial Surgery, Ehime University School of
Medicine.
Neoadjuvant therapy plays an important role for organ preservation and
survival rate in the treatment of oral cancer. We clinically compared
the effect of neoadjuvant radiotherapy and chemoradiotherapy in patients
with oral cancer. We retrospectively examined 47 patients diagnosed with
oral squamous cell carcinoma who underwent neoadjuvant therapy followed
by curative surgery in the oral and maxillofacial surgery department of
Ehime University Hospital. We divided them into two groups: radiotherapy
alone (24 cases) and chemoradiotherapy (23 cases). The patients in the
radiotherapy group underwent irradiation of 32.6 +/- 5.0 Gy (mean +/-
SD). The patients in the chemoradiotherapy group received a low-dose
fraction of cisplatin (8 mg/mm2/day, 5 days a week; total dose: 139.4
+/- 67.1 mg) and 5-fluorouracil (300 mg/mm2/day, 5 days a week; total
dose: 5,900 +/- 1,839.8 mg) combined with simultaneous irradiation of
31.0 +/- 3.2 Gy. None of the 24 patients had a complete response to
radiotherapy alone and 12 (50%) had a partial response. Six (26%) of the
23 patients had a complete response to chemoradiotherapy and 12 (52%)
had a partial response. The primary control rate (82.6%) to
chemoradiotherapy was higher than that (67.5%) to radiotherapy alone
although no significant difference was found. The 5-year survival rate
was 64.3% in the radiotherapy group and 62.8% in the chemoradiotherapy
group. The findings of the present study suggest that while the
combination of radiation and cisplatin/5-fluorouracil in neoadjuvant
therapy for oral cancer may not bring a significant benefit to improve
survival rate, the primary local control rate is improved in comparison
with radiotherapy alone.
23
UI - 11921969
AU - Meijer van Putten JB
TI -
[Mouth and throat cancer; new developments]
SO - Ned Tijdschr Tandheelkd 1996 Jan;103(1):31-2
24
UI - 11921961
AU - Roodenburg JL
TI -
[Maxillofacial oncology; quality through cooperation and concentration]
SO - Ned Tijdschr Tandheelkd 1996 Feb;103(2):48-9
25
UI - 11921466
AU - Ossenkoppele GJ
TI -
[Hematology and dentistry. Part V. Clinical manifestations of
hematological malignancies in the oral cavity]
SO - Ned Tijdschr Tandheelkd 1996 Jun;103(6):210-2
AD - Academisch Ziekenhuis van de Vrije Universiteit te Amsterdam, De
Boelelaan 1117, 1081 HV Amsterdam.
Haematological malignancies like acute and chronic leukemias, malignant
lymphoma and plasma cell disorders may exhibit oral manifestation during
their course. In this article the oral manifestation of a number of
haematological malignancies presented in the oral cavity as well as the
complications of the treatment are described.
26
UI - 12027954
AU - Hsu S; Borke JL; Lewis JB; Singh B; Aiken AC; Huynh CT; Schuster GS;
TI -
Caughman GB; Dickinson DP; Smith AK; Osaki T; Wang XF
Transforming growth factor beta 1 dysregulation in a human oral
carcinoma tumour progression model.
SO - Cell Prolif 2002 Jun;35(3):183-92
AD - Department of Oral Biology and Maxillofacial Pathology, Medical College
of Georgia, Augusta, GA 30912-1126, USA. shsu@mail.mcg.edu
A human oral tumour progression model was established that consists of
normal epithelial cells and three cell lines representing stages from
dysplastic to metastatic cells. To investigate the impact of exogenous
transforming growth factor-beta 1 on this model system, we analysed the
responsiveness of those cells to transforming growth factor-beta 1 and
explored the potential mechanism underlying the transforming growth
factor-beta 1 activity. We found that the growth of all cell types,
regardless of their stage of tumour progression, is inhibited by
transforming growth factor-beta 1, although to different degrees.
Transforming growth factor-beta 1 induced the expression of
cyclin-dependent kinase inhibitors p15(INK4B), p21WAF1/(CIP1) and
p27(KIP1). In contrast, transforming growth factor-beta 1 was found to
stimulate the invasive potential of one cell type that represents the
most advanced stage of tumour phenotype, suggesting that the impact of
transforming growth factor-beta 1 on functional features of tumour cells
other than cellular proliferation may play a significant role in the
process of oral tumour progression.
27
UI - 11921919
AU - van der Waal I
TI -
[Mouth neoplasms: a review]
SO - Ned Tijdschr Tandheelkd 1996 Sep;103(9):345-7
AD - Vakgroep Mondziekten en Kaakchirurgie/Orale Pathologie, Vrije
Universiteit te Amsterdam, Academisch Centrum Tandheelkunde Amsterdam
(ACTA).
An overview is presented of the epidemiology, etiology, clinical and
diagnostic aspects, treatment and possible prevention of oral cancer.
The dental profession may play a key role in the early detection of
cancer and possible precursor lesions such as leukoplakia and
erythroplakia. Since the use of tobacco is considered to be the main
etiologic factor in oral cancer the dentist can play an active role in
its primary prevention by informing his patients about the adverse
effect of tobacco use and by encouraging patients to enter tobacco
cessation programs.
28
UI - 11921920
AU - Roodenburg JL; Nauta JM; Vermey A
TI -
[Treatment of mouth cancer. General principles as well as surgical
aspects]
SO - Ned Tijdschr Tandheelkd 1996 Sep;103(9):348-9
AD - Afdeling Mondziekten, Kaakchirurgie en Bijzondere Tandheelkunde, sectie
Oncologie, Academisch Ziekenhuis Groningen, Postbus 30.001, 9700 RB
Groningen.
An overview is presented of the various treatment modalities in head and
neck cancer, the emphasis being on oral cancer. Evaluation of the neck
with regard to the possible presence of regional lymph node metastases
is an integral part of the examination and treatment of patients with
oral cancer. A strong plea is made for a multidisciplinary approach in
the treatment and rehabilitation of this patient group.
29
UI - 11921926
AU - Meijer van Putten JB
TI -
[Treatment of mouth cancer at the end of the nineteenth century]
SO - Ned Tijdschr Tandheelkd 1996 Sep;103(9):377-8
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