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NCI CANCERLIT^® Search: Penile Cancer - August 2002

National Cancer Institute^®
Last Modified: August 1, 2002

Penile reconstruction for extramammary Paget's disease.
Treatment of pearly penile papules with CO2 laser.
[Diagnosis and treatment of penile cancer]
Primary synovial sarcoma of the penis.
[Penis metastasis of prostate carcinoma]
Prostate carcinoma with testicular or penile metastases. Clinical, pathologic, and immunohistochemical features.

Table of Contents

1
UI - 12055441
AU - Hatoko M; Kuwahara M; Tanaka A; Yurugi S; Niitsuma K; Iioka H
TI - Penile reconstruction for extramammary Paget's disease.
SO - Ann Plast Surg 2002 Jun;48(6):672-5
AD - Division of Plastic Surgery, Nara Medical University, 840 Shijocho, Kashihara, Nara 634-0813, Japan.
The authors report their experience of an extremely rare case of extramammary Paget's disease presenting a deformational change of the penis, which required penile reconstruction after tumor resection. Tumor cells had invaded the dermis beyond the basement membrane of the epidermis. Tumor cells were found at the epithelium of the urethra, but had not invaded the corpus cavernosum. However, fibrotic changes were found in the corpus cavernosum. More than half the length of the penis was resected. Penile reconstruction was performed using a free sensory radial forearm flap. The defects in the mons pubis, scrotum, and the remaining corpus cavernosum were covered using a meshed split skin graft or sheeted split skin graft. Ten months after the operation, the tumor had not recurred and no metastasis was found. The urinary stream was narrow compared with that of a healthy man, but urinary voiding had not been disturbed. Sensory recovery was 12 mm with the two-point discrimination test at the distal end of the reconstructed penis.

2
UI - 12135521
AU - Lane JE; Peterson CM; Ratz JL
TI - Treatment of pearly penile papules with CO2 laser.
SO - Dermatol Surg 2002 Jul;28(7):617-8
AD - Section of Dermatology, Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA.
BACKGROUND: Pearly penile papules are angiofibromas found on the corona and sulcus of the glans penis. While these represent a benign condition, psychological and cosmetic concerns often prompt patients to seek therapeutic removal of these lesions. Multiple therapeutic modalities have been reported; however, use of CO2 laser has proven to be the most effective to date. OBJECTIVE: To demonstrate the efficacy of CO2 laser in treating pearly penile papules. METHODS: Case report. RESULTS: We report the successful treatment of pearly penile papules in an African American man with CO2 laser. CONCLUSION: The use of CO2 laser is an effective treatment for pearly penile papules. J. E. Lane, MD, C. M. Peterson, MD, and J. L. Ratz, MD have indicated no significant interest with commercial supporters.

3
UI - 12089846
AU - Kvarstein B; Fossa SD; Harvei S
TI - [Diagnosis and treatment of penile cancer]
SO - Tidsskr Nor Laegeforen 2002 May 10;122(12):1194-7
AD - Urologisk seksjon Akershus universitetssykehus 1474 Nordbyhagen.
BACKGROUND: Penile cancer is a rare malignancy in Norway with about 40 new cases each year. MATERIAL AND METHODS: An overview on diagnosis and treatment of penile cancer is given and the guidelines from the European Association of Urology are presented. RESULTS: Phimosis and poor genital hygiene are pre-disposing conditions for penile cancer. Condylomata acuminatum and leukoplakia should be regarded as premalignant lesions. The superficial form of penile cancer should be treated by laser, surgery or radiotherapy. When the cancer infiltrates into corpus cavernosum or corpus spongiosum, or the tumour displays a poorly differentiated histology, a partial or total amputation of the penis has to be performed. Inguinal lymphadenectomy is recommended in patients presenting with a tumour > or = pT2 or if the histology reveals a moderately or poorly differentiated cancer. Five-year survival rate is about 80% for patients with localised tumour, and about 50% in patients with regional lymph node metastasis. INTERPRETATION: We recommend that the treatment of penile cancer is performed in the regional hospitals.

4
UI - 12131325
AU - Sasso F; Delicato G; Gentile G; Falabella R
TI - Primary synovial sarcoma of the penis.
SO - J Urol 2002 Aug;168(2):633
AD - Division of Urology, Policlinico A. Gemelli-Catholic University of Rome, Rome, Italy.

5
UI - 12101483
AU - Schellhammer F; Nazari S; Krug B
TI - [Penis metastasis of prostate carcinoma]
SO - Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 2002 Jul;174(7):904

6
UI - 12173328
AU - Tu SM; Reyes A; Maa A; Bhowmick D; Pisters LL; Pettaway CA; Lin SH;
TI - Troncoso P; Logothetis CJ Prostate carcinoma with testicular or penile metastases. Clinical, pathologic, and immunohistochemical features.
SO - Cancer 2002 May 15;94(10):2610-7
AD - Department of Genitourinary Medical Oncology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. stu@notes.mdacc.tmc.edu
BACKGROUND: Despite the proximity, prostate carcinoma seldom metastasizes to the penis or testis. METHODS: In the current study, the authors retrospectively examined the clinical history of 12 patients with prostate carcinoma and testicular or penile metastases. Pathologic review and immunohistochemical staining were performed on tumors from eight of these patients. RESULTS: Patients with prostate carcinoma and testicular or penile metastasis responded to androgen ablative therapy (median duration, 33 months). They were predisposed to developing persistent or recurrent urinary symptoms and visceral metastases. Six of 9 evaluable patients had elevated serum carcinoembryonic antigen levels (> 6 ng/mL), whereas 2 of 10 patients had low or undetectable serum prostate specific antigen levels (< 4 ng/mL). In seven of the eight patients for whom specimens were available, the tumors were found to contain histologic features that were compatible with a diagnosis of ductal or endometrioid adenocarcinoma of the prostate. CONCLUSIONS: Patients with prostate carcinoma and testicular or penile metastases have unique clinical and pathologic characteristics. Many of these patients' tumors are compatible with a subtype of prostate carcinoma known as ductal adenocarcinoma. Further studies need to be performed to elucidate the biologic basis of the various histologic subtypes of prostate carcinoma.

The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.

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