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Abramson Cancer CenterNCI CANCERLIT® Search: Salivary Gland Cancer - August 2002
National Cancer Institute®
Last Modified: August 1, 2002
- Collagenous spherulosis in epithelial-myoepithelial carcinoma of the parotid gland. Histological and immunohistological study of a case.
- Duchenne muscular dystrophy-rhabdomyosarcoma, ichthyosis vulgaris/acute monoblastic leukemia: association of rare genetic disorders and
- Mucosa-associated lymphoid tissue lymphoma in Sjogren's syndrome: initial and follow-up imaging features.
- [Recurrent benign tumors of parotid gland: the role of the surgery]
- Solitary central nervous system metastasis from acinic cell carcinoma of the parotid gland.
- Quality of life after parotid and temporal bone surgery for cancer.
- Laparoscopically harvested omental flap for head and neck reconstruction.
- Simultaneous harvest of intercostal nerves and elevation of rectus abdominis musculocutaneous flap for facial nerve cable grafting.
- [Clinicopathological study of salivary duct carcinoma]
- Nodal metastasis in major salivary gland cancer: predictive factors and effects on survival.
- Guanylin and functional coupling proteins in the human salivary glands and gland tumors : expression, cellular localization, and target
- Centrosomal abnormalities, multipolar mitoses, and chromosomal instability in head and neck tumours with dysfunctional telomeres.
- Salivary duct carcinoma of minor salivary gland origin: report of a case involving the cavernous sinus.
Table of Contents
1
UI - 12021508
AU - Boor A; Jurkovic I; Kocan P; Jenca A
TI -
Collagenous spherulosis in epithelial-myoepithelial carcinoma of the
parotid gland. Histological and immunohistological study of a case.
SO - ORL J Otorhinolaryngol Relat Spec 2002 Mar-Apr;64(2):148-51
AD - Institute of Pathology, Faculty of Medicine, P.J. Safarik University in
Kosice, Slovak Republic.
Previously unreported histological and immunohistochemical features of
collagenous spherulosis in an epithelial-myoepithelial carcinoma found
in an 80-year-old woman are described. The multinodular tumor located in
the right parotid gland was completely removed surgically. No local
recurrence of the tumor appeared during the 22-month period of periodic
checkups. This is believed to be the first report on collagenous
spherulosis in an epithelial-myoepithelial carcinoma of the salivary
gland. Different immunohistochemical characteristics of epithelial and
myoepithelial neoplastic cells were found very useful for their analysis
namely in parts of the tumor where one cell type greatly predominated
(e.g. clear cell-type predominance). The double staining of histological
sections can in this sense be recommended for the differentiation from
other clear cell tumors of salivary glands allowing the correct
categorization of the neoplasm. Copyright 2002 S. Karger AG, Basel
2
UI - 12116087
AU - Jakab Z; Szegedi I; Balogh E; Kiss C; Olah E
TI -
Duchenne muscular dystrophy-rhabdomyosarcoma, ichthyosis vulgaris/acute
monoblastic leukemia: association of rare genetic disorders and
childhood malignant diseases.
SO - Med Pediatr Oncol 2002 Jul;39(1):66-8
AD - Department of Pediatrics, Medical and Health Science Center, University
of Debrecen, Debrecen, Hungary.
3
UI - 12130459
AU - Tonami H; Matoba M; Yokota H; Higashi K; Yamamoto I; Sugai S
TI -
Mucosa-associated lymphoid tissue lymphoma in Sjogren's syndrome:
initial and follow-up imaging features.
SO - AJR Am J Roentgenol 2002 Aug;179(2):485-9
AD - Department of Radiology, Kanazawa Medical University, Daigaku 1-1,
Uchinada, Kahoku, Ishikawa, 920-0293, Japan.
OBJECTIVE: We describe five cases of mucosa-associated lymphoid tissue
(MALT) lymphoma in patients with Sjogren's syndrome with emphasis on the
initial and follow-up imaging features. CONCLUSION: In three patients,
the lymphoma initially arose in the salivary gland, and in two patients,
the ocular adnexa. Two patients received no treatment but did have close
follow-up for 15 months and 2 years, respectively; no progression of the
disease was observed. In the other three patients, although complete
remission was achieved in the primary site, the disease spread to other
mucosal sites during follow-up periods of 1, 3, and 9 years,
respectively. Our findings show that MALT lymphoma in patients with
Sjogren's syndrome tends to originate in the organs targeted by
Sjogren's syndrome, and, despite the indolent nature of MALT, the
lymphoma tends to spread to other mucosal sites during the follow-up
period.
4
UI - 12068476
AU - Mercante G; Makeieff M; Guerrier B
TI -
[Recurrent benign tumors of parotid gland: the role of the surgery]
SO - Acta Otorhinolaryngol Ital 2002 Apr;22(2):80-5
AD - Clinica Otorinolaringoiatrica e patologia cervico-facciale, Universita
di Parma. giuseppe.mercante@wanadoo.fr
Parotid gland tumor recurrences can prove problematic both in terms of
facial nerve trauma during surgery and for the possible transformation
into malignancy. Between 1981 and 2001 a total of 40 patients (23 women,
17 men; average age 48; age range 20-79 years) underwent surgery for
recurrent parotid gland tumors. The average time between the first and
the second surgical procedures was approximately 10 years. Five subjects
underwent surgery several times for the same pathology. The Authors feel
that MRI imaging is an essential tool for the evaluation of
infiltrations into the soft tissues. The following surgical procedures
were performed: enucleation in 2 cases; exofacial partial parotidectomy
(PP) in 1; lower polar PP with functional neck dissection in 1; total
parotidectomy (TP) with preservation of the facial nerve in 31 cases; TP
with functional neck dissection in 2; TP with sectioning of the facial
nerve in 2 and TP with transmandibular buccopharyngectomy and
myocutaneous gran dorsal muscle flap in 1 case. Histology proved
positive for the following: pleomorphous adenoma in 21 cases,
adenocarcinoma in 11, aggressive fibromatosis in 2, cystadenolymphoma in
1, parotiditis in 1, lipoma in 1, cystic lymphoid hyperplasia in 1,
histiofibrosarcoma in 1 and neurofibrosarcoma in 1. The surgical
technique used was retrograde dissection of the facial nerve starting
from one of the peripheral branches. Post-operatively, whenever a facial
paralysis was encountered it proved difficult to recover. Paralysis of
the nerve was permanent only in the 2 subjects where sectioning proved
necessary because of infiltration by carcinoma. In 6 subjects recovery
of the paralysis took one year, in 4 it took 6 months and in 2 other
cases 3 months. In 22 cases there was only a slight paralysis of some
branches which recovered during the post-operative period. We do not
have definitive data on 4 subjects either because the period of time
since surgery is still too short or because they did not come in for
subsequent check-ups. The results of our study show that total
parotidectomy should be the treatment of choice in case of benign
parotid gland tumors and in particular for pleomorphic adenoma.
5
UI - 11881770
AU - Lesniak MS; Tihan T; Olivi A
TI -
Solitary central nervous system metastasis from acinic cell carcinoma of
the parotid gland.
SO - J Otolaryngol 2002 Feb;31(1):38-41
AD - Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore,
Maryland 21287, USA.
6
UI - 12150613
AU - Kwok HC; Morton RP; Chaplin JM; McIvor NP; Sillars HA
TI -
Quality of life after parotid and temporal bone surgery for cancer.
SO - Laryngoscope 2002 May;112(5):820-33
AD - Department of Otolaryngology-Head and Neck Surgery, Green Lane Hospital,
Auckland, New Zealand.
OBJECTIVES: The purposes of this study were to examine the quality of
life (QL) of patients who received treatment for cancer of the parotid
or temporal region, and to identify factors contributing to it. The
relationships between clinician-based measures of treatment outcome and
the patient-based counterparts were also evaluated. METHODS: A
retrospective, cross-sectional study was conducted on 23 patients who
had received either a temporal bone resection or a combination of
parotidectomy and radiotherapy. The QL survey involved both global QL
and measures of the appearance, communication, hearing, physical,
psychological, and social domains. Patients were assessed clinically for
their performance status, facial nerve function, disfigurement, and
hearing and the results were compared with patient-rated QL. Correlation
between the QL variables and global QL was identified using Spearman
correlation tests. RESULTS: Ongoing physical symptoms, communication
difficulties, and social disturbances were associated with poorer global
QL (P <.05). No correlation was detected between global QL and objective
disfigurement, facial function, and measures of hearing loss. With the
exception of hearing testing, clinical assessments generally did not
correlate well with patient ratings. CONCLUSION: QL measures provide
insight into patients' perceptions of the treatment outcome but do not
necessarily correlate with the clinicians' views. The use of a global QL
measure overcomes the difficulty of extrapolating the impact of symptom
scores or observational measures on patients' overall quality of
survival.
7
UI - 12150631
AU - Nishimura T; Kanehira E; Tsukatani T; Furukawa M
TI -
Laparoscopically harvested omental flap for head and neck
reconstruction.
SO - Laryngoscope 2002 May;112(5):930-2
AD - Department of Otolaryngology-Head and Neck Surgery, Kanazawa University
School of Medicine, Japan. nishimut@orl.m.kanazawa-u.ac.jp
8
UI - 12142674
AU - Takushima A; Asato H; Harii K; Masashi S
TI -
Simultaneous harvest of intercostal nerves and elevation of rectus
abdominis musculocutaneous flap for facial nerve cable grafting.
SO - Plast Reconstr Surg 2002 Aug;110(2):541-4
AD - Department of Plastic and Reconstructive Surgery, Graduate School of
Medicine, University of Tokyo, Japan. takushima-pla@h.u-tokyo.ac.jp
9
UI - 12138700
AU - Shimizu A; Yamane M; Ito H; Araki S; Yoshida T; Suzuki M
TI -
[Clinicopathological study of salivary duct carcinoma]
SO - Nippon Jibiinkoka Gakkai Kaiho 2002 Jun;105(6):727-31
AD - Department of Otolaryngology, Tokyo Medical University, Tokyo.
Salivary duct carcinoma (SDC) was first described by Kleinsesser in 1968
and was classified as an independent entity by the 1991 Revised World
Health Organization. It is a rare but highly malignant tumor. We
reviewed pathology in 49 cases of salivary adenocarcinoma, and diagnosed
6 cases as SDC. All had a rapidly enlarged mass in the parotid gland.
All were men, and 4 involved facial palsy and metastasis to cervical
lymph nodes. Fine needle aspiration biopsy was conducted in 3 cases, but
none was diagnosed as SDC. Two had chemotherapy, but showed no effect.
All underwent surgery, but only 1 survived more than 4 years.
Immunohistochemically, none showed s-100 protein. Four showed PCNA and
p53 protein. Highly positive cells of PCNA and p53 were found around
comedo necrosis.
10
UI - 12162768
AU - Bhattacharyya N; Fried MP
TI -
Nodal metastasis in major salivary gland cancer: predictive factors and
effects on survival.
SO - Arch Otolaryngol Head Neck Surg 2002 Aug;128(8):904-8
AD - Division of Otolaryngology, Brigham & Women's Hospital, Harvard Medical
School, Boston, Mass 02115, USA.
OBJECTIVES: To determine how regional nodal metastasis affects survival
in patients with major salivary gland malignancy and to identify
clinical predictors for nodal disease. METHODS: Major salivary gland
cancer cases with nodal sampling were identified from the Surveillance,
Epidemiology, and End Results cancer database for 1988 through 1998.
Kaplan-Meier survival analysis was conducted to compare patients with
and without histopathologic evidence of nodal disease. Multivariate
logistic regression analysis was used to determine the influence of
clinical predictors on the presence of regional nodal disease. RESULTS:
A total of 1268 patients with major salivary gland malignancy and
regional node sampling were identified. Mean age at diagnosis was 58.3
years, with a male-female ratio of 1:4. Mean tumor size was 3.0 cm.
Overall mean survival time was 83 months (95% confidence interval, 80-87
months). Patients with no evidence of nodal cancer had significantly
improved survival over patients with any pathologically positive nodes
(mean survival time, 100 months vs 59 months, respectively; P<.001).
Patient age, tumor histopathologic type, facial nerve involvement,
extraglandular involvement, tumor grade, and tumor size were significant
clinical predictors of nodal disease. Facial nerve involvement, tumor
grade, and squamous cell carcinoma subtype exhibited the highest
increased odds ratios for nodal metastasis. CONCLUSIONS: Nodal disease
significantly decreases survival in patients with major salivary gland
malignancy. Tumor histopathologic type, facial nerve involvement,
extraglandular tumor extension, and tumor grade are the most important
predictors of nodal disease.
11
UI - 12163390
AU - Kulaksiz H; Rehberg E; Stremmel W; Cetin Y
TI -
Guanylin and functional coupling proteins in the human salivary glands
and gland tumors : expression, cellular localization, and target
membrane domains.
SO - Am J Pathol 2002 Aug;161(2):655-64
AD - Department of Molecular Cell Biology, Institute of Anatomy and Cell
Biology, Philipps-University, Marburg, Germany.
Cystic fibrosis transmembrane conductance regulator (CFTR)-mediated
secretion of an electrolyte-rich fluid is a major but incompletely
understood function of the salivary glands. We provide molecular
evidence that guanylin, a bioactive intestinal peptide involved in the
CFTR-regulated secretion of electrolyte/water in the gut epithelium, is
highly expressed in the human parotid and submandibular glands and in
respective clinically most relevant tumors. Moreover, in the same organs
we identified expression of the major components of the guanylin
signaling pathway, ie, guanylin-receptor guanylate cyclase-C, cGKII, and
CFTR, as well as of the epithelial Cl(-)/HCO(3)(-) anion exchanger type
2 (AE2). At the cellular level, guanylin is localized to epithelial
cells of the ductal system that, based on its presence in the saliva, is
obviously released into the salivary gland ducts. The guanylin-receptor
guanylate cyclase-C, cGKII, CFTR, and AE2 are all confined exclusively
to the apical membrane of the same duct cells. These findings implicate
guanylin as intrinsic regulator of electrolyte secretion in the salivary
glands. We assume that duct epithelial cells synthesize and release
guanylin into the saliva to regulate electrolyte secretion in the ductal
system by an intraductal luminocrine signaling pathway. Moreover, the
high expression of guanylin in pleomorphic adenoma and Warthin tumors
(cystadenolymphoma), the most common neoplasms of salivary glands,
predicts guanylin as a significant marker in tumor pathology.
12
UI - 12107843
AU - Gisselsson D; Jonson T; Yu C; Martins C; Mandahl N; Wiegant J; Jin Y;
TI -
Mertens F; Jin C
Centrosomal abnormalities, multipolar mitoses, and chromosomal
instability in head and neck tumours with dysfunctional telomeres.
SO - Br J Cancer 2002 Jul 15;87(2):202-7
AD - Department of Clinical Genetics, University Hospital, SE-221 85 Lund,
Sweden. david.gisselsson@klingen.lu.se
Carcinomas of the head and neck typically exhibit complex chromosome
aberrations but the underlying mutational mechanisms remain obscure.
Evaluation of cell division dynamics in low-passage cell lines from
three benign and five malignant head and neck tumours revealed a strong
positive correlation between multipolarity of the mitotic spindle and
the formation of bridges at anaphase in both benign and malignant
tumours. Cells exhibiting a high rate of mitotic abnormalities also
showed several chromosome termini lacking TTAGGG repeats and a high
frequency of dicentric chromosomes. Multicolour karyotyping demonstrated
a preferential involvement in structural rearrangements of chromosomes
with deficient telomeres. The majority of malignant, mitotically
unstable tumours expressed the reverse transcriptase subunit of
telomerase. These data indicate that some of the genomic instability in
head and neck tumours is initiated by telomere dysfunction, leading to
the formation of dicentric chromosomes. These form chromosome bridges at
mitosis that could prevent the normal anaphase-telophase transition. In
turn, this may cause an accumulation of centrosomes and mitotic
multipolarity. Telomerase expression does not confer total stability to
the tumour genome but could be crucial for moderating the rate of
chromosomal evolution.
13
UI - 12149749
AU - Urban SD; Hall JM; Bentkover SH; Kadish SP
TI -
Salivary duct carcinoma of minor salivary gland origin: report of a case
involving the cavernous sinus.
SO - J Oral Maxillofac Surg 2002 Aug;60(8):958-62
AD - Division of Oral and Maxillofacial Surgery, Department of Surgery, Mayo
Clinic and Mayo Graduate School of Medicine, Rochester, MN 55905, USA.
urban.scott@mayo.edu
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.
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