National Cancer Institute®
Last Modified: September 1, 2002
UI - 12161615
AU - Fukuzawa R; Sakamoto J; Heathcott RW; Hata JI
TI - A necropsy case of Denys-Drash syndrome with a WT1 mutation in exon 7.
SO - J Med Genet 2002 Aug;39(8):e48
AD - Department of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. firstname.lastname@example.org
UI - 11939407
AU - Malik K; Yan P; Huang TH; Brown KW
TI - Wilms' tumor: a paradigm for the new genetics.
SO - Oncol Res 2000;12(11-12):441-9
AD - University of Bristol, Department of Pathology and Microbiology, School of Medical Sciences, University Walk, UK. email@example.com
Carcinogenesis can be triggered by a diverse range of molecular lesions, a variety of which can be illustrated by Wilm's tumor (WT), a pediatric kidney cancer. Molecular defects observed in WTs include several independent targets and mechanisms best exemplified by changes on the short arm of chromosome 11. This article will review the molecular pathology of WT and emphasize the broader ramifications for cancer genetics. Consideration will be given to carcinogenic pathways, novel cellular molecules, and technologies that will assist in the rapid interpretation and assimilation of DNA sequence data arising from the sequencing of the human genome.
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.