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Abramson Cancer CenterNCI CANCERLIT® Search: Mouth Cancer - October 2002
National Cancer Institute®
Last Modified: October 1, 2002
- Clinical significance of interleukin-6 and interleukin-6 receptor expressions in oral squamous cell carcinoma.
- The pattern of expression of Mn and Cu-Zn superoxide dismutase varies among squamous cell cancers of the lung, larynx, and oral cavity.
- Oral "hairy" leucoplakia in an African AIDS patient.
- Epidemiologic study of the association between alcohol habits and oral leukoplakia.
- Gingival metastasis in lung cancer.
- Do Ki67, S-phase, S + G2M and DNA ploidy, evaluated by flow cytometry, reveal locoregional metastasis in oral cavity and oropharynx carcinomas?
- Combined modality treatment of oral and oropharyngeal cancer including neoadjuvant intraarterial cisplatin and radical surgery followed by
- Importance-rating using the University of Washington quality of life questionnaire in patients treated by primary surgery for oral and
- Ulcerated mass of the retromolar area.
- Invasive front in oral squamous cell carcinoma: image and flow cytometric analysis with clinicopathologic correlation.
- [Salvage surgery in squamous cell carcinoma of the oral cavity]
- High-titer acquired factor V inhibitor responsive to corticosteroids and cyclophosphamide in a patient with two malignant tumors.
- Zila issued patent for use of video imaging in detecting oral cancer.
- Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia.
- Combined radial forearm and pharyngeal flaps for soft palate reconstruction.
- Acquired vascular lesion of the lower lip.
- Firm enlargement of the dorsolateral tongue.
- Lining the mouth floor with prelaminated fascio-mucosal free flaps: clinical experience.
- [Carcinoma cuniculatum of the oral cavity. A contribution to the differential diagnosis of potentially malignant papillary lesions of
- Long-term survival outcome in transhyoid resection of base of tongue squamous cell carcinoma.
- Prognostic value of sentinel node in oral cancer.
- Speech and swallowing function after reconstruction with a radial forearm free flap or a pectoralis major flap for tongue cancer.
- [Evaluation of occult lymph node metastasis in lower lip cancers and approach to N(0) neck metastasis]
- [Lipoma of the lip. A rare differential diagnosis]
- The evaluation of dysphagia following radical surgery for oral and pharyngeal carcinomas by cine-magnetic resonance imaging (Cine-MRI).
- Tuberculous granuloma and adenoid cystic carcinoma presenting as a single buccal space mass.
- [Adenosquamous carcinoma of the palate]
- [Occupational exposure and cancer of the oral cavity and pharynx]
- Mycosis fungoides involving the oral cavity.
- [Arterial chemoembolization in the combined treatment of malignant tumors of the tongue and maxilla: preliminary results]
- Transcriptional expression profiles of oral squamous cell carcinomas.
- Unusual periapical pathosis--adenoid cystic carcinoma.
- Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral
- Abnormalities of molecular regulators of proliferation and apoptosis in carcinoma of the oral cavity and oropharynx.
- Sentinel lymph node analysis in squamous carcinoma of the oral cavity and oropharynx.
- Expression of melanocytic differentiation markers in malignant melanomas of the oral and sinonasal mucosa.
- HPV in "carcinoma in situ" associated with HIV/AIDS infection: a case report.
- [Infantile myofibromatosis of the tongue - a case-report]
- Malignant melanoma of the oral mucosa in a 17-year-old adolescent girl.
- In vitro cytotoxic dose-relation of cisplatin and sodium thiosulphate in human tongue and oesophageal squamous carcinoma cell lines.
- Oral cancer campaign.
- Research halted at Indian centre accused of misconduct.
- Impacted supernumerary tooth developed under palatal polyp.
- Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is an indicator of malignant behavior in oral squamous cell carcinoma.
- Weight loss predicts mortality after recurrent oral cavity and oropharyngeal carcinomas.
- The posteriorly based platysma flap in oral and facial reconstruction: A case series.
- [Electrochemotherapy, a new antitumor treatment: first clinical trial]
- Spindle cell lipoma of the oral cavity. Report of a rare intramuscular case with fine needle aspiration findings.
Table of Contents
1
UI - 12211049
AU - Wang YF; Chang SY; Tai SK; Li WY; Wang LS
TI -
Clinical significance of interleukin-6 and interleukin-6 receptor
expressions in oral squamous cell carcinoma.
SO - Head Neck 2002 Sep;24(9):850-8
AD - Department of Otolaryngology, Taipei-Veterans General Hospital, 201,
Sec. 2, Shih-Pai Road, Taipei, Taiwan.
BACKGROUND: Recent studies showed that interleukin-6 (IL-6) played a
role in tumor development. However, available information about the
prognostic significance of IL-6 and IL-6 receptors (IL-6R) for oral
squamous cell carcinoma (OSCC) is limited. METHODS: Eighty-six patients
with OSCC were enrolled. Immunohistochemical staining was used to
determine IL-6R expression and in-situ hybridization for IL-6 mRNA
transcripts in surgical specimens. Clinicopathologic correlation was
evaluated by chi-square test and survival by log rank test. RESULTS:
Expression rates of IL-6R and IL-6 mRNA transcripts in tumor specimens
were 73.3% and 54.7%, much higher than those in nontumor mucosa (p
<.001). IL-6R overexpression was associated with larger tumors and more
advanced histologic grade (p <.05). The presence of IL-6 mRNA
transcripts was inversely correlated with distant metastasis, lymph node
involvement, and second primary SCC (p <.05) and predicted better
survival (p =.007). CONCLUSIONS: IL-6-IL-6R coexpression was rather high
in OSCC, and IL-6 mRNA transcript expression might influence patient
survival. The biologic role of IL-6-IL-6R coexpression in OSCC needs
additional investigation. Copyright 2002 Wiley Periodicals, Inc. Head
Neck 24: 850-858, 2002
2
UI - 12211050
AU - Piyathilake CJ; Bell WC; Oelschlager DK; Heimburger DC; Grizzle WE
TI -
The pattern of expression of Mn and Cu-Zn superoxide dismutase varies
among squamous cell cancers of the lung, larynx, and oral cavity.
SO - Head Neck 2002 Sep;24(9):859-67
AD - Division of Nutritional Biochemistry and Molecular Biology, University
of Alabama at Birmingham, University Station, Birmingham, Alabama 35294,
USA. piyathic@uab.edu
BACKGROUND: Despite the importance of reactive oxygen species (ROS) in
the development of smoking-related cancers, little is known about the
pattern of expression of ROS scavengers in these cancers. METHODS: In
this present study, we examined the expression of manganese superoxide
dismutase (Mn-SOD) and copper/zinc superoxide dismutase (Cu-Zn-SOD),
which are essential enzymes that eliminate ROS, in squamous cell cancers
(SCCs) of the lung (n = 12), larynx (n = 13), and oral cavity (n = 20).
RESULTS: SCCs of larynx and oral cavity showed significantly enhanced
immuhistochemical expression of Mn-SOD compared with the matched
uninvolved epithelium. The higher expression of Mn-SOD was shown to be
late and early events in the process of SCC development in the larynx
and the oral cavity, respectively. The expression of Mn-SOD in SCCs of
the lung was significantly lower compared with luminal cells of the
uninvolved epithelium but not compared with basal cells or an average
expression of SOD in basal and luminal cells. The expression of both
Mn-SOD and cytoplasmic or nuclear Cu-Zn-SOD in bronchial epithelium
adjacent to invasive cancer was significantly lower compared with its
expression in the uninvolved bronchial epithelium away from cancer. This
resulted in a significant difference in SOD expression between cancer
and uninvolved bronchial epithelium away from cancer but not between
cancer and uninvolved epithelium adjacent to cancer. CONCLUSIONS: There
are significant differences in the expression of Mn-SOD and Cu-Zn-SOD
among SCCs of the lung, larynx, and oral cavity. The results also
suggest that variations in distance between cancer and uninvolved
tissues evaluated could contribute to conflicting results of SOD
expression. Copyright 2002 Wiley Periodicals, Inc. Head Neck 24:
859-867, 2002
3
UI - 3734224
AU - De Maubeuge J; Ledoux M; Feremans W; Zissis G; Goens J; Andre J;
TI -
Gourdain JM; Menu R; De Wit S; Cran S; et al
Oral "hairy" leucoplakia in an African AIDS patient.
SO - J Cutan Pathol 1986 Jun;13(3):235-41
A 34-year-old African patient with AIDS developed a new form of oral
leucoplakia closely resembling the "hairy" leucoplakia described by
Greenspan in male homosexuals in the San Francisco area. A herpes-like
virus was seen on ultrastructural analysis with electron microscopy.
This case supplies further evidence suggesting that the syndrome in
patients originating in Central Africa is similar to the acquired
immunodeficiency syndrome (AIDS) reported in American patients.
4
UI - 6583042
AU - Gupta PC
TI -
Epidemiologic study of the association between alcohol habits and oral
leukoplakia.
SO - Community Dent Oral Epidemiol 1984 Feb;12(1):47-50
In a house-to-house survey in Ernakulam district, Kerala State, 10914
individuals were interviewed for their tobacco and alcohol habits and
examined for the presence of oral leukoplakia. Very few females (1.6%)
were found to be alcohol users and they were excluded from further
analysis. Among 7604 males, 30.4% used alcohol regularly, 25.4%
occasionally and 44.2% were non-users. The prevalence of leukoplakia was
significantly higher among regular (5.7%) and occasional (3.9%) users
than among non-users (2.9%) of alcohol. Alcohol usage was found to be
related to age as well as tobacco habits. The prevalence of leukoplakia
was higher among alcohol users in each age-group as well as in each
tobacco habit category. After age-adjustment the difference between
alcohol users and non-users, although reduced, remained significant. For
most tobacco habit categories the trend remained similar after
age-adjustment except for the mixed habits group, for which there was a
reversal of the trend. The alcohol habit may, perhaps, produce
discernible effects only in association with other 'weak' etiological
risk factors, such as a single tobacco habit of smoking or chewing
rather than a 'strong' etiologic factor such as the mixed habits of
chewing and smoking.
5
UI - 11956629
AU - Tanaka M; Hiraki A; Ueoka H; Bessho A; Kiura K; Takigawa N; Kodani T;
TI -
Miyatake K; Hamada N; Kishimoto T; Tanimoto M; Harada M
Gingival metastasis in lung cancer.
SO - Oncol Rep 2002 May-Jun;9(3):571-4
AD - Department of Medicine II, Okayama University Medical School, Okayama
700-8558, Japan. motoyuki@cb3.so-net.ne.jp
Gingival metastasis is an extremely rare manifestation of lung cancer,
and exhibits rapid growth with various clinical symptoms. Physicians
must appropriately manage patients with lung cancer who develop gingival
metastasis. Clinical records of patients with lung cancer treated at the
Department of Internal Medicine II, Okayama University Hospital, between
1976 and 1998 were retrospectively reviewed. The medical literature was
searched by Medline to identify reports of gingival metastasis from lung
cancer. Three of 729 (0.41%) lung cancer patients developed gingival
metastasis in our hospital between 1976 and 1998, and 9 additional cases
of this type of metastasis were found in the literature. All were male,
and median age was 57.5 years (range, 47 to 70). There were no clear
correlations between development of gingival metastasis and either
histologic type or location of the primary lesion. Chemotherapy or
radiotherapy was effective for treatment of gingival metastasis, and the
quality of life was improved. However, survival after development of
gingival metastasis was very short, with median survival of only 4
months.
6
UI - 11956630
AU - Tirelli G; Sidari L; Giacomarra V; Papanikolla L; Sasso F; Russolo M;
TI -
Melato M
Do Ki67, S-phase, S + G2M and DNA ploidy, evaluated by flow cytometry,
reveal locoregional metastasis in oral cavity and oropharynx carcinomas?
SO - Oncol Rep 2002 May-Jun;9(3):575-80
AD - Department of Otorhinolaryngology, Cattinara Hospital, I-34149 Trieste,
Italy.
Tumour cell proliferation is an important biological prognostic
parameter to be considered alongside clinical and histopathological
parameters. It has been evaluated by immunohistochemistry using
proliferative markers (PCNA, Ki67, etc.) and by flow cytometry
considering DNA content, growth fraction (S + G2M) and S-phase fraction.
Our aim was to evaluate by flow cytometry both Ki67 and S-phase
fraction, S + G2M, DNA content in patients surgically treated for oral
cavity and/or oropharynx carcinomas. The study, performed on archival
material, analysed the significance and prognostic reliability of these
biological parameters to reveal locoregional metastasis and evaluated
their possible correlation with clinical and histopathological
parameters. In conclusion, tumour cell proliferation seems not to be
useful in revealing the presence of locoregional metastasis in oral
cavity and oropharynx carcinomas. Thus, new approaches are required.
7
UI - 12069515
AU - Kovacs AF; Schiemann M; Turowski B
TI -
Combined modality treatment of oral and oropharyngeal cancer including
neoadjuvant intraarterial cisplatin and radical surgery followed by
concurrent radiation and chemotherapy with weekly docetaxel - three year
results of a pilot study.
SO - J Craniomaxillofac Surg 2002 Apr;30(2):112-20
AD - Department of Maxillofacial Plastic Surgery, Johann Wolfgang
Goethe-University Frankfurt Medical School, Frankfurt am Main, Germany.
A.Kovacs@em.uni-frankfurt.de
BACKGROUND: A new four-modality treatment of primary oral and
oropharyngeal squamous cell carcinomas was evaluated with regard to
feasibility, tolerance, and survival. PATIENTS AND METHODS: Seventy
three operable patients (100%) with histologically proven untreated
stage I to stage IV disease received at least one cycle of neoadjuvant
intraarterial chemotherapy with 150 mg/m(2) cisplatin neutralized with
sodium thiosulphate, followed by radical operation for the tumour with a
simultaneous selective neck dissection (clinically negative neck), or
modified radical neck dissection (nodal involvement), followed by
adjuvant chemoradiation over 5 weeks (51.9 Gy, systemic docetaxel 25
mg/m(2), once every week). RESULTS: Ninety-six per cent of patients were
operated on, 68% had postoperative radiation, 57% concomitant
chemotherapy; 44% fulfilled the complete protocol. There have been 11
local or regional recurrences to date, three of which were treated by
salvage surgery. Eighteen patients died, in nine of them death was
tumour-related. Seventy five per cent lived after a median observation
time of 33 months. Cumulative survival was 74% calculated for 4 years.
CONCLUSION: The presented multimodality regimen proved feasible and
showed better survival for the whole population and for all tumour
stages when compared with the treatment-dependent prognosis index of the
DOSAK (German-Austrian-Swiss Cooperative Group on tumours of the
maxillofacial region). Copyright 2002 Published by Elsevier Science Ltd.
on behalf of European Association for Cranio-Maxillofacial Surgery.
8
UI - 12069517
AU - Rogers SN; Laher SH; Overend L; Lowe D
TI -
Importance-rating using the University of Washington quality of life
questionnaire in patients treated by primary surgery for oral and
oro-pharyngeal cancer.
SO - J Craniomaxillofac Surg 2002 Apr;30(2):125-32
AD - Mossley, Cheshire, UK. snrogers@globalnet.co.uk
BACKGROUND: There are now several validated and widely accepted head and
neck cancer questionnaires. These record patients subjective levels of
function and dysfunction, as well as symptoms related to their cancer
and its treatment. One popular measure is the University of Washington
head and neck cancer questionnaire (UW-QOL). Domain importance-ratings
were added to the second version of the questionnaire, which was
published in 1997. It is unique amongst head and neck cancer
questionnaires in this respect. AIM: The purpose of the study was to
evaluate UW-QOL with particular reference to domain importance-rating.
It was also the intention to investigate how the importance-ratings
related to 'quality of life' and comment on the cumulative scoring of
the questionnaire. METHODS: Forty-eight patients with previously
untreated oral or oro-pharyngeal cancer were recruited. All were treated
by primary surgery. Questionnaires were completed pre-operatively, 6
months and 1 year post-operatively. RESULTS: This study demonstrates a
wide variation in importance-ratings. Both pre- and post-treatment there
was a general lack of correlation between importance-rating and domain
scores. At all time points, patients tended to rate speech, chewing and
swallowing as more important than the other UW-QOL domains. The
cumulative UW-QOL score correlated strongly with the new single item QOL
question. CONCLUSION: It remains unclear how best to incorporate
importance-ratings into a single UW-QOL total score. However, for
individual patients they can assist in setting priorities in treatment
strategies. Copyright 2002 European Associaton for Cranio-Maxillofacial
Surgery. Published by Elsevier Science Ltd. All rights reserved.
9
UI - 12142867
AU - Courrier B; Plantier F; Kuffer R
TI -
Ulcerated mass of the retromolar area.
SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 Jun;93(6):635-9
AD - University of Paris, Cochin Hospital, France.
bruno.dr.courrier@wanadoo.fr
10
UI - 12142875
AU - Noguchi M; Kinjyo H; Kohama GI; Nakamori K
TI -
Invasive front in oral squamous cell carcinoma: image and flow
cytometric analysis with clinicopathologic correlation.
SO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 Jun;93(6):682-7
AD - Department of Oral Surgery, Sapporo Medical University, Hokkaido, Japan.
noguchi@sapmed.ac.jp
OBJECTIVE: Pathologists have drawn attention to the invasive tumor front
(ITF) in the determination of the biologic aggressiveness of oral
cancer. We have attempted to discover the prognostic significance of
cancer cells with abnormal DNA content at the ITF of oral squamous cell
carcinoma. STUDY DESIGN: A comparative DNA analysis by means of image
cytometry and flow cytometry was conducted to confirm the usefulness of
image cytometry in detecting cancer cells having abnormal DNA content at
the ITF. The prognostic value of cancer cells with abnormal DNA content
ws examined by a multivariate analysis for 195 patients with oral
squamous cell carcinoma. RESULTS: In the comparative DNA analysis, it
was suggested that image cytometry is useful for detecting cancer cells
with abnormal DNA content (4c exceeding rate [4cER]), which is
associated with poor prognosis of patients with oral squamous cell
carcinoma. In the multivariate analysis, 3 independent factors were
found to significantly influence cause-specific survival. These are, in
decreasing order of influence, (1) abnormal DNA content (4cER), (2)
clinical stage, and (3) growth type. CONCLUSION: The presence of cancer
cells with abnormal DNA content of the ITF in conjunction with clinical
findings (clinical stage and growth type) can give additional useful
information when selecting treatment strategies for oral cancer
patients.
11
UI - 12173283
AU - De Zinis LO; Ghizzardi D; Casati E; Nicolai P; Antonelli AR
TI -
[Salvage surgery in squamous cell carcinoma of the oral cavity]
SO - Acta Otorhinolaryngol Ital 2002 Jun;22(3):135-41
AD - Clinica Otorinolaringoiatrica, Universita di Brescia.
redaelli@master.cci.unibs.it
The objective of this work was to evaluate the results of salvage
surgery in squamous cell carcinoma of the oral cavity. In the period
1983-1998, 127 patients consecutively underwent surgical treatment. Of
these, 80 cases had not been treated previously (Group I), while 47
patients had come under our observation after radiotherapy alone or
other treatment had failed (Group II). Local recurrence was observed in
29 cases, local/regional in 10 cases, and exclusively regional in eight
cases. In both groups, the surgical T-approach was prevalently transoral
(55 cases in Group I and 24 in Group II). A transmandibular approach was
taken in most of the remaining patients (22 cases in Group I and 16 in
Group II). One hundred patients (65 in Group I and 35 in Group II)
underwent laterocervical neck dissection. The neoplasms in group I were
staged as follows: pT1, 29%; pT2, 37.5%; pT3, 12.5%; pT4, 21%. In group
II, the neoplasms were stages as: pT0, 17%; pT1, 21%; pT2, 38%; pT3,
13%; pT4, 11% (Group II). The overall 5-year survival rate was 38% and
the overall determinate 5-year survival rate was 45%, distributed as
follows in the two groups: 51% of the patients in Group I, 36% of the
patients in Group II (p = 0.01). Restricting the analysis to Group II,
the difference in the three year survival rate was 54% among the
patients at stages I-II and 25% among the patients suffering from a
recurrence at stages III-IV (p = 0.04). In patients whose recurrence was
limited to the primary tumor, survival at 3 years was 49%; in those
whose recurrence also had nodal involvement, survival was 27% (p =
0.05). Lastly, the 5-year survival rate was 45% in the patients whose
recurrence had been diagnosed late and only 24% in the 24 patients whose
recurrence had been diagnosed within a year of prior treatment (p =
0.09). In conclusion, the life expectancy of patients undergoing salvage
surgery for squamous cell carcinoma of the oral cavity is significantly
less with respect to patients undergoing first round treatment. This
difference appears significant only in patients with a recurrence that
was diagnosed at an advanced stage. In accordance with the previously
published data, an early recurrence (within a year) and the presence of
a recurrence in the neck are unfavorable prognostic factors.
12
UI - 12221671
AU - Bayani N; Rugina M; Haddad-Vergnes L; Lelong F
TI -
High-titer acquired factor V inhibitor responsive to corticosteroids and
cyclophosphamide in a patient with two malignant tumors.
SO - Am J Hematol 2002 Sep;71(1):33-6
AD - Hematology Laboratory, Creteil Intercommunal Hospital Center, France.
nazanine.bayani@chicreteil.fr
We report a 79-year-old man with two simultaneous malignant tumors
(buccal epidermoid carcinoma and prostatic adenocarcinoma) who developed
a severe bleeding complication at the site of the buccal tumor as well
as a massive cerebral hematoma after a skull trauma. Laboratory findings
showed the presence of a high-titer specific factor V inhibitor. The
patient failed to respond to intravenous immunoglobulins, but both
clinical and laboratory improvement was obtained after treatment with
corticosteroids and cyclophosphamide. Copyright 2002 Wiley-Liss, Inc.
13
UI - 12271841
AU - Anonymous
TI -
Zila issued patent for use of video imaging in detecting oral cancer.
SO - Dent Today 2002 Sep;21(9):36
14
UI - 12234999
AU - Kresty LA; Mallery SR; Knobloch TJ; Song H; Lloyd M; Casto BC; Weghorst
TI -
CM
Alterations of p16(INK4a) and p14(ARF) in patients with severe oral
epithelial dysplasia.
SO - Cancer Res 2002 Sep 15;62(18):5295-300
AD - Division of Environmental Health Sciences, School of Public Health,
Comprehensive Cancer Center, The Ohio State University, Columbus, OH
43210, USA.
A number of genetic aberrations have been reported in end-stage squamous
cell carcinoma of the head and neck, including p16(INK4a) and p14(ARF)
(INK4a/ARF) inactivation rates of 70-85%. Still, the cell
cycle-regulatory genes p16(INK4a) and p14(ARF) remain poorly understood
in oral cavity premalignant lesions. This study evaluated INK4a/ARF
locus alterations in 26 patients (28 samples) deemed to be at increased
risk for malignant transformation to squamous cell carcinoma due to the
diagnosis of severe oral epithelial dysplasia. Microscopically confirmed
dysplastic oral epithelium and matching normal tissue were laser
capture-microdissected from paraffin sections, DNA was isolated, and
molecular techniques were used to evaluate p16(INK4a) and p14(ARF) gene
deletion, mutation, loss of heterozygosity (LOH), and hypermethylation
events. Deletion of exon 1beta, 1alpha, or 2 was detected in 3.8%,
11.5%, and 7.7% of patients, respectively. INK4a and ARF mutations were
detected in 15.4% and 11.5% of patients with severe dysplasia of the
oral epithelium. All identified mutations occurred in the INK4a/ARF
conserved exon 2. Allelic imbalance was assessed using three markers
previously reported to show high LOH rates in head and neck tumors. LOH
was found in 42.1%, 35.0%, and 82.4% of patients for the markers
IFNalpha, D9S1748, and D9S171, respectively. Hypermethylation of
p16(INK4a) and p14(ARF) was detected in 57.7% and 3.8% of patients,
respectively, using nested, two-stage methylation-specific PCR. The
highest rates of p16(INK4a) hypermethylation occurred in lesions of the
tongue and floor of the mouth. In addition, p16(INK4a) hypermethylation
was significantly linked to LOH in two or more markers. These data
support that INK4a/ARF locus alterations are frequent events preceding
the development of oral cancer and that p16(INK4a) inactivation occurs
to a greater extent in oral dysplasia than does p14(ARF) inactivation.
15
UI - 9643608
AU - Townend J
TI -
Combined radial forearm and pharyngeal flaps for soft palate
reconstruction.
SO - Br J Oral Maxillofac Surg 1998 Apr;36(2):156-7
16
UI - 12074233
AU - Flaitz CM
TI -
Acquired vascular lesion of the lower lip.
SO - Am J Dent 2002 Feb;15(1):67-8
AD - Department of Stomatology, University of Texas-Houston Health Science
Center, 77030-3402, USA. Catherine.M.Flaitz@uth.tmc.edu
17
UI - 12092993
AU - Flaitz CM
TI -
Firm enlargement of the dorsolateral tongue.
SO - Am J Dent 2002 Apr;15(2):139-40
AD - Department of Diagnostic Sciences, UT-Houston Dental Branch, TX
77030-3402, USA. Catherine.M.Flaitz@uth.tmc.edu
18
UI - 12210962
AU - Chiarini L; De Santis G; Bedogni A; Nocini PF
TI -
Lining the mouth floor with prelaminated fascio-mucosal free flaps:
clinical experience.
SO - Microsurgery 2002;22(5):177-86
AD - Section of Dentistry, Department of Neurosciences, Head and Neck and
Rehabilitation, Faculty of Medicine, University of Modena and Reggio
Emilia, Italy.
Soft-tissue defects of the mouth floor need thin, foldable, and pliable
tissues able to preserve local anatomy as well as chewing, phonation,
and deglutition. The oral mucosa is made of a stratified,
nonkeratinized, epithelium-secreting mucus, which lubricates the oral
cavity and facilitates tongue movements. No flap exists that can
reproduce the physiology of the oral mucosa better than the oral mucosa
itself. Prefabrication of mucosal flaps may represent the best solution.
Therefore, 10 consecutive cases of mouth floor cancer were treated with
prelamination of the fascia antibrachialis with mucosal grafts obtained
from the healthy cheek, and with subsequent transplantation 3 weeks
later. A significant increase in mucosal graft surface was seen in all
cases, with a mean size twice the original. All flaps healed
uneventfully. Follow-up time ranged between 2-60 months (average, 26.6
months). Morphological and functional results were excellent. Tongue
motility, speech intelligibility, and swallowing were reestablished in
all treated cases. Mucosal prelamination of the forearm fascia is
feasible and allows physiological reconstruction of oral cavity defects
up to 6 x 4 cm. Copyright 2002 Wiley Liss, Inc.
19
UI - 12185786
AU - Gassler N; Helmke B; Schweigert HG; Hassfeld S; Otto HF; Flechtenmacher
TI -
C
[Carcinoma cuniculatum of the oral cavity. A contribution to the
differential diagnosis of potentially malignant papillary lesions of
mouth mucosa]
SO - Pathologe 2002 Jul;23(4):313-7
AD - Pathologisches Institut der Universitat Heidelberg, Im Neuenheimer Feld
220/221, 69120 Heidelberg. Nikolaus_Gassler@med.uni-heidelberg.de
Although carcinoma cuniculatum clinically appears to be malignant,
histological evaluation often results in a false diagnosis of a benign
papillomatous lesion or pseudoepitheliomatous hyperplasia, because the
tumor usually displays a well differentiated tissue. In this report
morphological and immunohistological features in a rare case of
carcinoma cuniculatum of the oral cavity are described. Both clinical
features and histomorphological evaluation must be taken into
consideration when diagnosing the tumor.
20
UI - 12220214
AU - Azizzadeh B; Enayati P; Chhetri D; Maghami E; Larian B; Blackwell KE;
TI -
Abemayor E; Calcaterra TC
Long-term survival outcome in transhyoid resection of base of tongue
squamous cell carcinoma.
SO - Arch Otolaryngol Head Neck Surg 2002 Sep;128(9):1067-70
AD - Division of Head and Neck Surgery, UCLA School of Medicine, 62-132 CHS,
10833 Le Conte Ave, Los Angeles, CA 90095-1624, USA.
BACKGROUND: The transhyoid approach for the resection of squamous cell
carcinoma (SCC) of the base of the tongue continues to evolve and
remains controversial. We previously reported that the functional
outcome of this operation is superior to that of the traditional
transmandibular approaches. OBJECTIVE: To report our long-term survival
rates for T1, T2, and select T3 SCCs of the base of the tongue using the
transhyoid approach. PATIENTS AND METHODS: Twenty-eight patients with
SCC of the base of the tongue were treated using a transhyoid approach
at the University of California, Los Angeles, Medical Center between
1981 and 1998. RESULTS: All 28 patients underwent simultaneous neck
dissection, and 27 patients underwent postoperative radiation therapy.
The majority of the patients had advanced stage III or IV SCC.
Twenty-five of the 28 patients had clear margins in the final pathologic
specimen. The overall 3- and 5-year patient survival rates were 88.5%
and 80.0%, respectively. Tumor-specific 5-year survival rates were
80.0%, 84.6%, and 50.0% for T1, T2, and T3 tumors, respectively.
Stage-specific 5-year survival rates were 60.0%, 100.0%, and 80.0% for
stages II, III, and IV, respectively. CONCLUSIONS: The advantages of the
transhyoid approach to SCC of the base of the tongue in conjunction with
neck dissection and postoperative radiation therapy include excellent
long-term patient survival, improved swallowing and speech function,
outstanding tumor exposure, and minimal cosmetic deformity.
21
UI - 12365373
AU - Ionna F; Chiesa F; Longo F; Manola M; Villano S; Calabrese L; Lastoria
TI -
S; Mozzillo N
Prognostic value of sentinel node in oral cancer.
SO - Tumori 2002 May-Jun;88(3):S18-9
AD - Istituto Nazionale Tumori, Fondazione Pascale, Naples.
AIMS AND BACKGROUND: In stage I oral squamous cell carcinoma, clinical
examination and imaging techniques are unable to identify 60-90% of
patients at risk of micrometastasis, while the sentinel node biopsy
technique allows to avoid the morbidity of elective neck dissection in
patients not actually affected by micrometastases. MATERIALS AND
METHODS: Forty-one T1-T2N0 patients underwent lymphoscintigraphy after
peritumoral injection of human albumin labeled with 99Tc. Focal areas of
radiotracer uptake were marked on the skin preoperatively. The sentinel
lymph node (SLN) was identified by the combined use of blue dye and
gamma probe and subsequently removed. Complete neck dissection was then
performed in all patients and the histological findings were compared
with those of SLN biopsy. RESULTS: The SLN was identified in 95% of the
patients; in four cases (10%) two SLNs were isolated. In 18% of our
patients the SLNs were located outside the expected drainage area. When
the histology of the negative SLNs was compared with the pathological
status of the neck dissection specimens no false negatives were found.
Five SLNs in four patients contained micrometastases and were the only
positive lymph nodes. CONCLUSIONS: SLN biopsy can be a valuable staging
technique in T2 and T2 oral cancer with uninvolved neck in patients
whose lymphatic drainage of the neck has not been altered by previous
surgery or radiotherapy. It provides reliable detection of
micrometastasis, indicating which level(s) should be removed
ipsilaterally or contralaterally, and allows the surgeon to accurately
plan neck dissection, taking into consideration the pattern of lymphatic
drainage of each individual patient. In this way unnecessary neck
dissection and its morphofunctional sequelae can be avoided in a
considerable number of patients.
22
UI - 12353339
AU - Su WF; Chen SG; Sheng H
TI -
Speech and swallowing function after reconstruction with a radial
forearm free flap or a pectoralis major flap for tongue cancer.
SO - J Formos Med Assoc 2002 Jul;101(7):472-7
AD - Department of Otolaryngology, Head and Neck Surgery, Tri-Service General
Hospital, National Defense Medical Center, Taipei, Taiwan.
BACKGROUND AND PURPOSE: The tongue plays a more significant role in
English than in Mandarin, both in apical-palatal consonant production
and tense-lax distinction. Theoretically, the same surgical intervention
may produce a less significant impact on postoperative Mandarin
production. The impact of tongue reconstruction on Mandarin articulation
has not been reported. This study compared the tongue function outcome
obtained using two methods of tongue reconstruction, radial forearm free
flap transfer and pectoralis major flap transfer. METHODS: Twenty-five
patients with carcinoma of the tongue underwent tumor resection. The
surgical defects were reconstructed using a pectoralis major flap in six
patients and a radial forearm flap in 19 patients. Swallowing and speech
function were evaluated 6 months to 5 years after the reconstruction.
Speech intelligibility and a Mandarin articulation test were used to
evaluate the articulation proficiency before and after surgery. Clinical
evaluation of deglutition included a questionnaire on dietary habits and
a swallowing rating of 1 to 7. RESULTS: Clinical evaluation showed that
patients with free flap reconstruction had more intelligible speech (p =
0.014) even after total glossectomy. Assessment of data obtained by
clinical questionnaire showed no significant difference between the two
groups in swallowing function. Motility due to flap pliability increased
speech intelligibility but had little effect on swallowing function.
CONCLUSION: Our results suggest that radial forearm flap transfer is
better than pectoralis major flap transfer in preserving speech function
and that there is no significant difference between the two methods of
reconstruction in their impact on swallowing function.
23
UI - 12122624
AU - Kocaturk S; Ozdemir N; Erkam U; Uzun H; Babila A; Ozturk E
TI -
[Evaluation of occult lymph node metastasis in lower lip cancers and
approach to N(0) neck metastasis]
SO - Kulak Burun Bogaz Ihtis Derg 2002 Jan-Feb;9(1):41-5
AD - 2nd Department of Otolaryngology, SSK Training Hospital, Ankara, Turkey.
sinankocaturk@yahoo.com
OBJECTIVES: In this study, we evaluated the incidence of occult lymph
node metastasis and the approach to N0 necks in carcinoma of the lower
lip. PATIENTS AND METHODS: Sixty-eight patients who underwent surgery
for squamous cell carcinoma of the lower lip were monitored for a
minimum period of three years. All the patients were males (mean age 54
years; range 36 to 69 years). Preoperatively, 15 and 53 patients had N+
and N0 necks, respectively. Depending on the tumor localization,
unilateral or bilateral suprahyoid neck dissections were performed. Nine
patients underwent radical neck dissection following detection of
metastasis on histopathologic examination. RESULTS: Histopathologic
examination revealed metastasis in four patients (4/15; 26%) with N+
necks and in five patients (5/53; 9.4%) with N0 necks. Four patients
(6.7%) developed late cervical lymph node metastasis at level 3. No
evidence of neck disease was encountered in 93% of patients. CONCLUSION:
Suprahyoid neck dissection appears to be effective in detecting occult
lymph node metastasis. With improved surgical and histopathologic
techniques and consideration of skip metastasis, more aggressive
treatment approaches may be employed and better survival rates may be
obtained.
24
UI - 12132296
AU - Lischner S; Rosien F; Eiling S; Haacke TC; Hauschild A
TI -
[Lipoma of the lip. A rare differential diagnosis]
SO - Hautarzt 2002 Jun;53(6):400-2
AD - Klinik fur Dermatologie, Venerologie und Allergologie,
Christian-Albrechts-Universitat zu Kiel.
We report on a 49 year-old female patient with a cherry-sized tumor of
the lower lip, which over several years had steadily increased in size.
The patient was psychologically affected by the appearance of the tumor
and had difficulties to eat. We excised the tumor in local anaesthesia.
Histology confirmed the clinical suspicion of lipoma. A total of four
lipomas at this location have been reported world-wide.
25
UI - 12140643
AU - Kitano H; Asada Y; Hayashi K; Inoue H; Kitajima K
TI -
The evaluation of dysphagia following radical surgery for oral and
pharyngeal carcinomas by cine-magnetic resonance imaging (Cine-MRI).
SO - Dysphagia 2002 Summer;17(3):187-91
AD - Department of Otolaryngology, Head and Neck Surgery, Shiga University of
Medical Science, Otsu, Japan. hkitano@belle.shiga-med.ac.jp
Cine-magnetic resonance imaging (cine-MRI) creates moving pictures by a
video system and turbo-flash method that allow for high-speed MRI. This
report describes our experience using this new technique for dynamic
imaging using the fast spoiled GRASS (SPGR) sequence to study swallowing
in patients with dysphagia following radical surgery for oral cancer. We
defined two new parameters, laryngeal elevation and the angle of the
epiglottis, to quantify swallowing ability by cine-MRI. These variables
were markedly different in patients with dysphagia than they were in
healthy controls. Cine-MRI not only provides dynamic images of
swallowing but can generate objective measures of swallowing ability as
well.
26
UI - 12140418
AU - Landa LE; Kathju S; Nepomuceno-Perez MC; Gordon C; Sotereanos GC
TI -
Tuberculous granuloma and adenoid cystic carcinoma presenting as a
single buccal space mass.
SO - J Craniofac Surg 2002 Jul;13(4):533-7
AD - Division of Plastic, Reconstructive & Maxillofacial Surgery, Oral and
Maxillofacial Fellow, University of Pittsburgh and Hospital
Metropolitano, Craniomaxillofacial Surgery Unit, Valencia, Venezuela.
landale@msx.upmc.ed
We report an unusual case of a 58-year-old man with a "collision lesion"
of the buccal space. Initially diagnosed as tuberculoma, the patient
showed only partial response to an extensive course of antibiotics,
prompting more vigorous investigation. This revealed the presence of a
concomitant malignancy, specifically adenoid cystic carcinoma.
Definitive treatment was then achieved by surgical resection and flap
reconstruction with postoperative radiation therapy.
27
UI - 12189573
AU - Mancusi G; Susani M; Kornfehl J; Girsch W; Kautzky M
TI -
[Adenosquamous carcinoma of the palate]
SO - Laryngorhinootologie 2002 Aug;81(8):568-72
AD - Univ. Klinik fur Hals-, Nasen- und Ohrenkrankheiten, Germany.
A rare case of adenosquamous carcinoma in a 74 year-old man is reported.
Presenting as a nodule on the soft palate, diagnosis was prolonged
because of the benign macroscopic aspect. CT-scan and MR-tomography
showed an encapsulated lesion but biopsy and histologic examination
revealed the typical features of adenosquamous carcinoma. The tumour
consisted of adenocarcinoma and squamous cell carcinoma in close
proximity to minor salivary glands of which the tumour seemed to have
its origin. This entity, although rare in the head and neck region has
been documented to be very aggressive with early regional and
hematogenic metastasis. Therefore it has to be distinguished from other
tumours, especially from mucoepidermoid carcinomas of the salivary
glands, which have a better prognosis. Adenosquamous carcinoma is
considered to have poor radiosensitivity and chemotherapeutic approaches
have also not been successful in the literature. In our case radical
surgical therapy was performed by excision of the whole soft palate and
bilateral neck dissection. This resulted in total removal of the tumour
but revealed bilateral lymph node metastases. Vital functions were saved
by reconstruction of the palate with a free vascularized
tensor-fasciae-latae-perforator-flap. For the first time in a case of
adenosquamous carcinoma carcinoembryonic antigen in serum was monitored.
A pretherapeutical 29-fold elevation resulted in a marked decrease after
surgery, but supranormal values indicated remaining tumour burden which
was found in metastases in the lung. Because of the limitations in
therapy, early histologic diagnosis is most important in this highly
malignant tumour.
28
UI - 12189574
AU - Riechelmann H
TI -
[Occupational exposure and cancer of the oral cavity and pharynx]
SO - Laryngorhinootologie 2002 Aug;81(8):573-9
AD - Univ. HNO-Klinik Ulm, Germany. herbert.riechelmann@medizin.uni-ulm.de
BACKGROUND: Occupational risk factors for the development of laryngeal
cancer are well accepted, whereas the etiologic relationship between
occupational exposure to various noxious influences and the development
of cancer of the oral cavity and pharynx remain a matter of debate.
Based on published data, occupational risk factors for cancer of the
oral cavity and pharynx should be evaluated. METHODS: Publications since
1990 listed in the National Library of Medicine, textbooks and data
obtained from the German Employer's Liability Insurance Association were
evaluated. RESULTS: In several tobacco- and alcohol-adjusted
case-control and cohort studies, an association with occupation in
construction and metalworking industries, as painters, carpenters and
machine operators was consistently found. The relative risks or
standardized mortality rates ranged between 1.5 and 3. Some recent
investigations found an association for workers in the paper and rubber
industry. The results in regard to the textile and woodworking industry
were inconclusive. CONCLUSION: In cases with moderate isolated tobacco
or moderate isolated alcohol consumption, the risk attributable to
occupational factors and smoking or drinking are of similar magnitude.
According to German jurisdiction, a partial compensation of the acquired
disability is then justified. In pronounced combined tobacco and alcohol
consumption, the non-occupational risk factors increase exponentially
and occupational risks attain marginal weight.
29
UI - 12196250
AU - Chua MS; Veness MJ
TI -
Mycosis fungoides involving the oral cavity.
SO - Australas Radiol 2002 Sep;46(3):336-9
AD - Department of Radiation Oncology, Westmead Hospital, Sydney, Australia.
Mycosis fungoides is a malignant T-cell lymphoproliferative disease with
a predilection for cutaneous involvement. Extracutaneous disease is
uncommon and oral mucosal involvement is rare. We describe a case of
mycosis fungoides involving the hard palate treated with radiotherapy.
The relevant literature on this topic is reviewed.
30
UI - 12216485
AU - Suvorova IuV; Tarazov PG; Korytova LI; Sokurenko VP; Khazova TV
TI -
[Arterial chemoembolization in the combined treatment of malignant
tumors of the tongue and maxilla: preliminary results]
SO - Vestn Rentgenol Radiol 2002 Mar-Apr;(2):23-8
AD - Central Research Roentgenoradiological Institute, Ministry of Health of
the Russian Federation, Saint Petersburg.
The authors made a clinical evaluation of the efficiency of regional
bolus chemotherapy and embolization as a stage of combined therapy in
patients with inoperable cancer of the tongue and maxilla complicated by
bleeding episodes. Carotid angiography by attempting to make
chemoembolization was performed in 15 patients. The procedure could not
be done in full in 2 (13%) patients due to transient vascular and
neurological disorders. The remaining 13 (87%) patients had successful
chemoembolization of tumor-supplying arteries with 5-fluorouracil (700
mg/m2) and methotrexate (40 mg/m2) in combination with finely cut
hemostatic sponge and fragments of metallic spirals (n = 12) or regional
bolus injection of a cytostatic (n = 1) without arterial occlusion.
After embolization, bleeding episodes ceased in all the patients. Full
(n = 1) and partial (n = 6) responses to treatment or stabilization of
the process (n = 5) were noted in 12 (92%) cases, progression was only
in 1 (8%) case. The study suggests that chemoembolization of the
branches of the external carotid artery in patients with cancer of the
tongue and maxilla contributes to the arrest of chronic tumorous
bleeding and to the reduction in the risk for acute A combination of
systemic multidrug therapy, radiation therapy, and chemoembolization
stabilizes a tumorous process in most patients.
31
33
34
UI - 12237917
AU - Mendez E; Cheng C; Farwell DG; Ricks S; Agoff SN; Futran ND; Weymuller
TI -
EA Jr; Maronian NC; Zhao LP; Chen C
Transcriptional expression profiles of oral squamous cell carcinomas.
SO - Cancer 2002 Oct 1;95(7):1482-94
AD - Department of Otolaryngology: Head and Neck Surgery, University of
Washington, Seattle, Washington, USA.
BACKGROUND: Currently, the classification of oral squamous cell
carcinoma (OSCC) depends heavily on the clinical and pathologic
examination of tissue. This system can lead to the classification of
potentially heterogeneous tumors into single groups when they may have
different degrees of aggressiveness. No system to date has incorporated
genetic changes as a factor by which to classify OSCC tumors. METHODS:
To test the hypothesis that OSCC has a genome-wide genetic expression
profile that differs from normal oral tissue and that transcriptional
expression profiling can be used to characterize the heterogeneity among
tumors, the authors examined the genetic expression profiles of 26
invasive squamous cell carcinomas of the oral cavity and oropharynx, 2
premalignant lesions, and 18 normal oral tissue samples using
oligonucleotide arrays that contained probes representing approximately
7000 full-length human genes. RESULTS: Using hierarchical clustering
analysis, the data show that oral carcinomas are distinguishable from
normal oral tissue based on genome-wide transcriptional expression
patterns. However, there is genetic expression profile heterogeneity
among tumors of a particular histopathologic grade and stage. In
addition, using a statistical approach that integrated normalization and
regression analysis, the authors found 314 genes that were expressed
differentially in the OSCC samples with statistical significance (P
UI - 12360690
AU - Abbott PV
TI -
Unusual periapical pathosis--adenoid cystic carcinoma.
SO - Aust Endod J 2001 Aug;27(2):73-5
UI - 12006539
AU - Ha PK; Pai SI; Westra WH; Gillison ML; Tong BC; Sidransky D; Califano JA
TI -
Real-time quantitative PCR demonstrates low prevalence of human
papillomavirus type 16 in premalignant and malignant lesions of the oral
cavity.
SO - Clin Cancer Res 2002 May;8(5):1203-9
AD - Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins
School of Medicine, Baltimore, Maryland 21205, USA.
PURPOSE: Human papillomavirus (HPV) type-16 has been associated with
invasive squamous cell carcinoma of the head and neck. This study
examines the role of HPV-16 in the progression of oral head and neck
cancer by determining the quantity of HPV-16 DNA in premalignant and
malignant lesions, using real-time quantitative PCR, to more accurately
determine the role of HPV-16 in oral head and neck squamous cell
carcinogenesis. EXPERIMENTAL DESIGN: We examined 102 microdissected
premalignant head and neck lesions (85 from the oral cavity), 34
invasive oral cavity squamous cell carcinomas, as well as 18 invasive
tumors known to be HPV positive by traditional molecular technology for
the presence of HPV-16 DNA using real-time quantitative PCR. RESULTS:
HPV DNA was detected in 1 of 102 premalignant lesions (0.98%), 1 of 34
(2.9%) invasive oral cavity carcinomas, and 14 of 18 (78%) known
HPV-positive tumors. CONCLUSIONS: HPV-16 infection and integration is
seldom found in oral premalignant lesions and invasive carcinoma, and
therefore rarely contributes to malignant progression in the oral
cavity. Furthermore, quantitative PCR is a useful technique that
reliably excludes contaminated samples and those with minimal HPV DNA
content that is unlikely to be significant in carcinogenesis.
UI - 11893452
AU - Kuropkat C; Venkatesan TK; Caldarelli DD; Panje WR; Hutchinson J;
TI -
Preisler HD; Coon JS; Werner JA
Abnormalities of molecular regulators of proliferation and apoptosis in
carcinoma of the oral cavity and oropharynx.
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