What is the anus? The anus is an organ that lies at the end of the digestive tract below the rectum. It consists of two sections: the anal canal and the anus (or anal verge). The anal canal is a 3-4 cm long structure that lies between the anal sphincter (one of the muscles controlling bowel movements) just below the rectum and the anal verge which represents the transition point between the digestive tract and the skin on the outside of the body. Muscles within the anal canal and anus control the passage of stool from the rectum to outside the body. What is anal cancer? Normally, cells in the body will grow and divide to replace old or damaged cells in the body. This growth is highly regulated, and once enough cells are produced to replace the old ones, normal cells stop dividing. Tumors occur when there is an error in this regulation and cells continue to grow in an uncontrolled way. ... read more on Anal Cancer: The Basics
Expert answers to common questions about anal cancer.
Treatment Options for Peri-anal Paget's Disease
In 1986 and l987 I was operated on twice to excise Peri-anal Paget's disease and obtain clean margins. Pathology revealed underlying adenocarcinoma and the sphincter was excised, but not destroyed. After the second operation there were still some underlying cancer cells, but I was told I would just be watched--and I was for every three
Resuming sexual relations after completion of chemotherapy and radiation therapy for anal cancer
Dear OncoLink "Ask The Experts," I have just completed chemo and radiotherapy treatment for anal cancer I am worried about having sex again. Presently I have a yellow mucus discharge from my vagina and anus. It does seem to be getting better. Can I hope it will disappear and is it normal?James M. Metz, MD, Editor-in-Chief of OncoLink and Assistant
Proton Therapy for Anal Cancer
Dear OncoLink "Ask The Experts," Is the new proton beam radiation a viable option for anal cancers? James M. Metz, MD, Editor-in-Chief of OncoLink and Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania, responds:Proton beam therapy is being explored as a possible form of treatment for a number of cancers.
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Reviews of presentations from professional meetings related to anal cancer.
Intergroup RTOG 98-11: A phase III randomized study of 5-fluorouracil (5-FU), mitomycin, and radiotherapy versus 5-fluorouracil, cisplatin and radiotherapy in carcinoma of the anal canal
Presenter: J.A. AjaniPresenter's Affiliation: M.D. Anderson Cancer Center, Houston, TXType of Session: ScientificBackground The current standard treatment of squamous cell carcinoma of the anus is concurrent chemoradiation (CRT) with 5-FU and mitomycin-C The 5-yr disease free survival (DFS) is ~65% Mitomycin-C has an undesirable
Intergroup RTOG 9811: Phase III Comparison of Chemoradiation With 5-FU and Mitomycin Vs. 5-FU and Cisplatin for Anal Canal Carcinoma: Impact on Disease-Free, Overall and Colostomy-Free Survival
Presenter: L.L. GundersonPresenter's Affiliation: Mayo Clinic Cancer Center ? Arizona, Scottsdale, AZType of Session: ScientificBackground Anal cancer is frequently a loco-regional disease The RTOG 8704/ECOG 1289 study showed the superiority of RT/5-FU/Mitomycin C over RT/5FU The current standard treatment of squamous cell
Long-term Quality of Life after Chemoradiation for Anal Cancer
Presenter: Prajnan DasPresenter's Affiliation: UT MD Anderson Cancer Center, Houston, TXType of Session: ScientificBackground There are an estimated 4700 cases/year of anal cancer in the US. Definitive radiation therapy with concurrent chemotherapy represents the standard of care for squamous cell carcinoma of the anus. RTOG 9811
NCI CANCERLIT® Search: Anal Cancer - October 2001
Reconstruction of perianal skin defect using a V-Y advancement of bilateral gluteus maximus musculocutaneous flaps: reconstruction Primary anorectal malignant melanoma: clinical features and results of surgical therapy in Singapore--a case...
NCI CANCERLIT® Search: Anal Cancer - September 2001
Table of ContentsHigh-dose radiation therapy and neoadjuvant plus concomitant chemotherapy with 5-fluorouracil and cisplatin in patients with locally advanced squamous-cell anal canal cancer: final results of a phase II study.What is the...
NCI CANCERLIT® Search: Anal Cancer - April 2002
Adenocarcinoma arising within a Crohn's-related anorectal fistula: a form of anal gland carcinoma? Current management of perianal intraepithelial neoplasia. [Complaints in the anal area. Risk a glance at the taboo zone!] Table of Contents ...