Vaginal Cancer: The Basics

Author: OncoLink Team
Content Contributor: Allyson Van Horn, MPH
Last Reviewed: August 13, 2024

Vaginal cancer is cancer that starts in the vagina. It is caused by vaginal cells growing out of control. As the number of cells grows, they form a tumor.

Vaginal cancer that has spread from the vagina to another part of the body is called metastatic cancer.

Risks

Some risk factors are:

Signs of Vaginal Cancer

Signs of vaginal cancer can be:

  • Vaginal bleeding that is not a period.
  • Bleeding after going through menopause.
  • Pain during sex.

Diagnosis of Vaginal Cancer

If your healthcare providers think you may have vaginal cancer, tests will be ordered. Here are some of the tests:

Staging Vaginal Cancer

To guide treatment, vaginal cancer is "staged." This stage is based on:

  • Where and how big your tumor is.
  • If there are cancer cells in the lymph nodes.
  • If there are cancer cells in other parts of the body.

Stages range from stage I (1, smallest, most confined tumors) to stage IV (4, tumors that have spread to other parts of the body, also called metastatic cancer). The stage and type of vaginal cancer will guide your treatment plan.

Treatment

Often, these treatments are used:

  • Surgery can be used to remove the cancer.
  • Radiation, the use of high energy x-rays to kill cancer cells, can be used. The types of radiation used are external beam radiation and brachytherapy. Sometimes they are both used.
  • Chemotherapy, the use of medications to kill cancer cells, can be given.

This article is a basic guide to vaginal cancer. You can learn more about your type of vaginal cancer and treatment by using the links below.

Vaginal Cancer: Staging and Treatment

Surgical Procedures: Surgical Staging for Vaginal Cancer

Resources for More Information: Gynecologic Cancers

American Cancer Society. Vaginal Cancer.

Bardawil, T (Ed.). Vaginal Cancer, Medscape, Updated May 3, 2012.

Beriwal, S., Demanes, D. J., Erickson, B., Jones, E., Jennifer, F., Cormack, R. A., ... & Viswanathan, A. N. (2012). American Brachytherapy Society consensus guidelines for interstitial brachytherapy for vaginal cancer. Brachytherapy, 11(1), 68-75.

de Martel, C., Plummer, M., Vignat, J., & Franceschi, S. (2017). Worldwide burden of cancer attributable to HPV by site, country and HPV type. International journal of cancer, 141(4), 664-670.

Hacker, N. F., Eifel, P. J., & van der Velden, J. (2015). Cancer of the vagina. International Journal of gynecology & obstetrics, 131, S84-S87.

Nasu, K et al. (2010) Primary mucinous adenocarcinoma of the vagina. European journal of gynecologic oncology: 31(6): 679-681.

National Comprehensive Cancer Network (2024). Vaginal Cancer. Version 2.2025.

Ozgul, N., Basaran, D., Boyraz, G., Salman, C., & Yuce, K. (2016). Radical Hysterectomy and Total Abdominal Vaginectomy for Primary Vaginal Cancer. International journal of gynecological cancer, 26(3), 580-581.

Pannu, H. K. (2014). Vaginal Cancer. In, Atlas of gynecologic oncology imaging (pp. 105-132). Springer New York.

Sinno, A. K., Saraiya, M., Thompson, T. D., Hernandez, B. Y., Goodman, M. T., Steinau, M., ... & Wilkinson, E. J. (2014). Human papillomavirus genotype prevalence in invasive vaginal cancer from a registry-based population. Obstetrics and gynecology, 123(4), 817.

United States Preventive Services Task Force Cervical Cancer Screening Guidelines http://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummaryFinal/cervical-cancer-screening

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