Menopause Caused by Cancer Treatment

Author: Courtney Misher, MPH, BS R.T.(T)
Last Reviewed: August 13, 2024

Menopause is when your menstrual cycles (periods) end. This happens when your ovaries make lower levels of estrogen (sex hormone that helps keep the female reproductive going) or if the ovaries are removed.

Some cancer treatments can cause menopause. These include:

Menopause caused by some cancer treatments can be temporary (short-term) or permanent (lifelong). It is hard to know if yours will be temporary or permanent, but your provider may be able to tell you what you can expect.

What symptoms can I expect from early menopause?

Symptoms of early menopause caused by cancer treatment can be more severe than when menopause happens naturally. Symptoms can be:

If you have any of these symptoms, talk with your care team. There are treatments that can help lessen these symptoms. Some of these treatments include hormones and some do not. Replacing estrogen or other hormones may not be safe for you. Talk with your care team if you are thinking about hormone replacement therapy (HRT).

How can I manage the symptoms?

Self-care actions can help lessen the symptoms of menopause. To lower the risk of side effects:

  • Avoid caffeine, alcohol, spicy foods, tight clothing, and cigarette smoke.
  • Exercise daily.
  • Lower stress as much as possible.
  • Keep your mind active.
  • Stay cool - keep your bedroom cool at night, use fans, and wear light clothing in layers.
  • Drink plenty of water.
  • Eat a well-balanced diet.
  • Use a water-based lubricant with sexual activity.

Talk with your care team before taking any medications, supplements, or herbs as these may affect your hormone levels and can affect your treatment.

When should I call my care team?

If symptoms are affecting your life and the self-care actions are not helping, talk with your provider. Your provider may be able to give you medication that can help.

Howard-Anderson J, Ganz PA, Bower JE, Stanton AL. Quality of life, fertility concerns, and behavioral health outcomes in younger breast cancer survivors: a systematic review. Journal of the National Cancer Institute. 2012;104(5):386-405.

Loibl S, Lintermans A, Dieudonne AS, Neven P. Management of menopausal symptoms in breast cancer patients. Maturitas. 2011;68(2):148-54.

Mann E, Smith MJ, Hellier J, Balabanovic JA, Hamed H, Grunfeld EA, et al. Cognitive behavioural treatment for women who have menopausal symptoms after breast cancer treatment (MENOS 1): a randomised controlled trial. The Lancet Oncology. 2012;13(3):309-18.

Mitsis D, Beaupin LK, O'Connor T. Reproductive complications. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 43.

National Cancer Institute website. Sexual health issues in women with cancer. www.cancer.gov/about-cancer/treatment/side-effects/sexuality-women. Updated January 23, 2020. Accessed January 25, 2021.

Shuster LT, Rhodes DJ, Gostout BS, Grossardt BR, Rocca WA. Premature menopause or early menopause: long-term health consequences. Maturitas. 2010;65(2):161-6.

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