Hepatotoxicity (Liver Damage)

Author: Marisa Healy, BSN, RN
Content Contributor: Katherine Okonak, LSW
Last Reviewed: August 02, 2024

What is Hepatotoxicity?

Hepatotoxicity is liver damage. It can be caused by medications, chemicals, or cancer itself. Many chemotherapy drugs can harm the liver since the liver’s job is to remove toxins from the body.

Hepatotoxicity is found through blood tests called "liver function tests” (LFTs). This blood test shows how well the liver is working. When found early, hepatotoxicity can often be treated.

How is hepatotoxicity treated?

Chemotherapy doses may be changed if you show signs of liver problems during treatment. Drinking alcohol can cause liver damage. You should talk to your provider to see if you can drink alcohol during treatment. 

When should I call my care team?

Call your care provider if you have:

Canadian Cancer Society. Liver problems. Retrieved 2024.

Kneuertz PJ, Maithel SK, Staley CA, Kooby DA. Chemotherapy-associated liver injury: impact on surgical management of colorectal cancer liver metastases. Annals of surgical oncology. 2011;18(1):181-90.

Robinson SM, Wilson CH, Burt AD, Manas DM, White SA. Chemotherapy-associated liver injury in patients with colorectal liver metastases: a systematic review and meta-analysis. Annals of surgical oncology. 2012;19(13):4287-99.

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