Pruritus (Itching)

Author: Marisa Healy, BSN, RN
Last Reviewed: July 29, 2024

What is pruritis?

Pruritus is another name for itching. Itching can be a side effect of some cancers and treatments. Some things that can cause itching are:

How is it treated?

You may be given skin care instructions to lessen the itch. Skincare can also prevent infection due to scratching. Itchiness can be treated by finding the cause.

Some ways to lessen itching may be to:

  • Limit baths and use the shower instead. Avoid hot water when washing or bathing. Wash only with gentle, soap-free cleansers.
  • After washing, gently dry your skin. Pat the area dry (don't rub) with a soft towel.
  • Use lotions and moisturizers daily if your care team says it is okay to do so. Choose gentle lotions without perfumes or dyes.
  • Wear natural fibers like cotton or linen clothing. Choose loose clothing that doesn't rub against your skin.
  • Drink 6-8 eight-ounce glasses of non-alcoholic fluids each day. Keeping hydrated can keep your skin moist and less itchy.
  • Keep your fingernails short to prevent scratching yourself.
  • If you are feeling itchy, placing lotion or a cool washcloth on the area may lessen the urge to scratch.

Medications may be prescribed to help with the itchiness. Antihistamines, sedatives, and antidepressants are medications that can help with itchiness.

When should I call my care team?

If itching is keeping you from sleeping or is not helped by skin care, call your care provider. If itching gets worse or you see signs of infection (fever, redness or oozing at the site, chills), call your care provider.

Ensslin CJ, Rosen AC, Wu S, Lacouture ME. Pruritus in patients treated with targeted cancer therapies: systematic review and meta-analysis. Journal of the American Academy of Dermatology. 2013;69(5):708-20.

Fischer A, Rosen AC, Ensslin CJ, Wu S, Lacouture ME. Pruritus to anticancer agents targeting the EGFR, BRAF, and CTLA-4. Dermatologic therapy. 2013;26(2):135-48.

Mayo Clinic. Itchy skin (pruritus) - Symptoms and causes. 2018.

Santini D, Vincenzi B, Guida FM, Imperatori M, Schiavon G, Venditti O, et al. Aprepitant for management of severe pruritus related to biological cancer treatments: a pilot study. The Lancet Oncology. 2012;13(10):1020-4.